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LOC129660761 ReSE screen-validated silencer GRCh37_chr2:98327684-98327873 [ Homo sapiens (human) ]

Gene ID: 129660761, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129660761
Gene description
ReSE screen-validated silencer GRCh37_chr2:98327684-98327873
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129660761 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97711221..97711410)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98169435..98169624)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98327684..98327873)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:98278969-98279610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16241 Neighboring gene U4 spliceosomal RNA Neighboring gene actin related protein 1B Neighboring gene chromosome 2 open reading frame 92 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:98304422-98305621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98307157-98307956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98323640-98324200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98324201-98324759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98329847-98330820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332052-98332567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332568-98333082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98340736-98341326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98356023-98356522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11794 Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98379903-98380684 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:98386577-98387090 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:98387091-98387603 Neighboring gene uncharacterized LOC124907861 Neighboring gene transmembrane protein 131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_157798.1 

    Range
    101..290
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    97711221..97711410
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791765.1 Reference GRCh38.p14 PATCHES

    Range
    637252..637441
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    98169435..98169624
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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