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LOC129660507 ReSE screen-validated silencer GRCh37_chr1:226249972-226250137 [ Homo sapiens (human) ]

Gene ID: 129660507, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129660507
Gene description
ReSE screen-validated silencer GRCh37_chr1:226249972-226250137
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence includes an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. A subregion was identified as a functional silencer in K562 erythroleukemia cells. This locus also represents an accessible chromatin region that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC129660507 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226061835..226062684)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (225249747..225250596)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226249536..226250385)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2643 Neighboring gene SDE2 telomere maintenance homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2644 Neighboring gene H3-3A divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2645 Neighboring gene H3.3 histone A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226270255-226271122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1872 Neighboring gene long intergenic non-protein coding RNA 1703 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:226295966-226296160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226299196-226299703 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:226302781-226303585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2646 Neighboring gene Sharpr-MPRA regulatory region 5028 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 1869

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_157544.2 

    Range
    101..950
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    226061835..226062684
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    225249747..225250596
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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