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A1bg alpha-1-B glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 117586, updated on 8-Feb-2025

Summary

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Official Symbol
A1bgprovided by MGI
Official Full Name
alpha-1-B glycoproteinprovided by MGI
Primary source
MGI:MGI:2152878
See related
Ensembl:ENSMUSG00000022347 AllianceGenome:MGI:2152878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C44
Summary
Acts upstream of or within growth hormone receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human A1BG (alpha-1-B glycoprotein). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Restricted expression toward liver adult (RPKM 526.2) See more
Orthologs
human all
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Genomic context

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See A1bg in Genome Data Viewer
Location:
15 D1; 15 25.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (60789438..60793119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (60917589..60921270, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9930014A18 gene Neighboring gene STARR-positive B cell enhancer ABC_E11590 Neighboring gene LRAT domain containing 1 Neighboring gene VISTA enhancer mm642 Neighboring gene predicted gene, 53894 Neighboring gene RIKEN cDNA 4930402D18 gene Neighboring gene predicted gene, 53895

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A liver specific gene that is expressed in growth hormone transgenic mice and in normal female mice as a function of age. Tiong JD, et al. Growth Horm IGF Res, 2006 Jun. PMID 16723264
  2. Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation. Shi W, et al. Dev Cell, 2021 Nov 8. PMID 34655525, Free PMC Article
  3. Cloning of a novel growth hormone-regulated rat complementary deoxyribonucleic acid with homology to the human alpha1B-glycoprotein, characterizing a new protein family. Gardmo C, et al. Endocrinology, 2001 Jun. PMID 11356721
  4. Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Uslu VV, et al. Nat Genet, 2014 Jul. PMID 24859337
  5. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of P5 protein cDNA #5 is liver-specific, sexually dimorphic, age-dependent, and may be involved in hepatocyte hyperplasia and liver enlargement.
    Title: A liver specific gene that is expressed in growth hormone transgenic mice and in normal female mice as a function of age.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within growth hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-1B-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081067.1 → NP_001074536.1  alpha-1B-glycoprotein precursor

    See identical proteins and their annotated locations for NP_001074536.1

    Status: VALIDATED

    Source sequence(s)
    AC130823
    Consensus CDS
    CCDS37085.1
    UniProtKB/Swiss-Prot
    Q19LI2
    Related
    ENSMUSP00000094151.4, ENSMUST00000096418.5
    Conserved Domains (3) summary
    smart00410
    Location:328 → 414
    IG_like; Immunoglobulin like
    pfam13895
    Location:234 → 314
    Ig_2; Immunoglobulin domain
    cl11960
    Location:419 → 510
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    60789438..60793119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19LI2.1 GenPept UniProtKB/Swiss-Prot:Q19LI2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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