BioSample Beta-Lactamase Antibiograms
Providing beta-lactamase antibiogram data
Background information about beta-lactamase submissions, including how to create beta-lactamase Sequin files, is provided on the Beta Lactamase Submissions page. The information below describes beta-lactamase antibiogram requirements.
Beta-lactamase antibiogram data are submitted using the Supplementary Files Submission Portal. On the 'Data type' tab, select the 'Beta-lactamase gene' option. On the 'General info' tab either reference an existing beta-lactamase BioSample accession, or use the 'register a BioSample' link to create a new beta-lactamase BioSample. On the 'Files' tab, submit your Sequin and Antibiogram files.
Download antibiogram template.
See example of a beta-lactamase antibiogram table.
Beta-lactamase antibiogram data are subject to content validation. If the error reports are not clear, please write to biosamplehelp@ncbi.nlm.nih.gov for assistance.
Mandatory Fields
- Sample name/Accession
- Antibiotic
- Resistance phenotype
- Measurement sign
- Measurement
- Measurement unit
- Laboratory typing method
- Testing standard
Provide either the 'sample name' you assigned to your BioSample, or the BioSample accession number.
Measurements for the following antibiotics are required.
Measurements for additional antibiotics can be provided, the complete list of recognized antibiotics is provided at the foot of this page.
| Required | aztreonam, cefotaxime, cefoxitin, ceftazidime |
|---|---|
| At least one required | amoxicillin, ampicillin, benzylpenicillin, piperacillin |
| At least one required | cefaclor, cephalothin |
| At least one required | cefotaxime-clavulanic acid, ceftazidime-clavulanic acid |
| At least one required | cloxacillin, oxacillin |
| At least one required | doripenem, ertapenem, imipenem, meropenem |
| Name | Synonym |
|---|---|
| high level aminoglycoside resistance | HLAR |
| intermediate | I |
| nonsusceptible | NS |
| not defined | N, ND |
| resistant | R |
| susceptible | S, sensitive |
| susceptible-dose dependent | SSD |
| Name | Synonym |
|---|---|
| < | less than |
| <= | less than or equal to |
| == | =, equal to |
| > | greater than |
| >= | greater than or equal to |
Antibiotic concentration measurement.
The measurement for a simple antibiotic should be a number.
The measurement for a combined antibiotic should be in format number1/number2.
The valid range for unit 'mg/L' is a positive number up to 1024; the valid range for unit 'mm' is between 6 and 150.
| Name | Synonym |
|---|---|
| mg/L | microgram/milliliter, microgram/millilitre, micrograms/milliliter, micrograms/millilitre |
The measurement units should be appropriate for selected lab typing method.
| Name | Synonym |
|---|---|
| MIC | broth dilution, broth microdilution, frozen broth microdilution, macrodilution, microbroth dilution, microdilution, minimal inhibitory concentration |
| Name | Synonym |
|---|---|
| CLSI | |
| missing |
Optional Fields
| Name | Synonym |
|---|---|
| Microscan | |
| Phoenix | |
| Sensititre | |
| Vitek |
| Name | Synonym |
|---|---|
| Becton Dickinson | |
| Biomérieux | Biom?rieux, Biomerieux, BiomŽrieux |
| Siemens | |
| Trek |
| Name | Synonym |
|---|---|
| 96-Well Plate | |
| E-Test | |
| GM-NEG |
All recognized antibiotics
You can also get the Antibiotics table in text format.
| Name | Synonym | Combination |
|---|---|---|
| G418 | ||
| GE2270A | ||
| GE37468 | ||
| Imipenem-EDTA-PA | ||
| L-681,217 | ||
| SB22484 | ||
| UK-69,753 | ||
| acridine dye | ||
| acriflavin | ||
| actinomycin | ||
| actinomycin D | ||
| amikacin | AMK | |
| amoxicillin | AMX | |
| amoxicillin-clavulanic acid | AMC, augmentin | yes |
| amphotericin B | ||
| ampicillin | AMP | |
| ampicillin-sulbactam | SAM | yes |
| amythiamicin A | ||
| anidulafungin | ||
| antibiotic A40926 | ||
| antibiotic A47934 | ||
| apramycin | ||
| arbekacin | ||
| arsphenamine | ||
| arylomycin | ||
| astromicin | ||
| aurodox | ||
| avilamycin | ||
| avoparcin | ||
| azamulin | ||
| azdimycin | ||
| azidamfenicol | ||
| azithromycin | AZM | |
| azlocillin | AZL | |
| aztreonam | ATM | |
| bacitracin | ||
| bacitracin A | ||
| bacitracin B | ||
| bacitracin F | ||
| balhimycin | ||
| bedaquiline | ||
| benzylpenicillin | ||
| bicyclomycin | ||
| bleomycin | ||
| bleomycin A2 | ||
| bleomycin B2 | ||
| bleomycinic acid | ||
| brodimoprim | ||
| butirosin | ||
| capreomycin | ||
| carbenicillin | CAR | |
| carbomycin | ||
| caspofungin | ||
| cefaclor | CEC | |
| cefadroxil | CFR | |
| cefalexin | ||
| cefalotin | ||
| cefamandole | FAM | |
| cefazolin | CFZ | |
| cefdinir | CDR | |
| cefditoren | CDN | |
| cefepime | FEP | |
| cefetamet | FET | |
| cefiderocol | ||
| cefixime | CFM | |
| cefmetazole | CMZ | |
| cefonicid | CID | |
| cefoperazone | CFP | |
| cefotaxime | CTX | |
| cefotaxime-clavulanic acid | yes | |
| cefotetan | CTT | |
| cefotiam | ||
| cefovecin | ||
| cefoxitin | FOX | |
| cefpirome | ||
| cefpodoxime | CPD | |
| cefpodoxime-proxetil | ||
| cefprozil | CPR | |
| ceftaroline | ||
| ceftazidime | CAZ | |
| ceftazidime-avibactam | yes | |
| ceftazidime-clavulanic acid | yes | |
| ceftibuten | CTB | |
| ceftiofur | ||
| ceftizoxime | ZOX | |
| ceftobiprole | ||
| ceftolozane-tazobactam | yes | |
| ceftriaxone | CRO | |
| cefuroxime | CXM | |
| celesticetin | ||
| cephalexin | LEX | |
| cephalothin | CEF | |
| cephamycin | ||
| cephapirin | HAP | |
| cephem | ||
| cephradine | RAD | |
| chalcomycin | ||
| chloramphenicol | CHL | |
| chloroeremomycin | ||
| chlortetracycline | ||
| cinoxacin | CIN | |
| ciprofloxacin | CIP | |
| clarithromycin | CLR | |
| clavulanic acid | CLA | |
| clinafloxacin | CLX | |
| clindamycin | CLI | |
| clofazimine | ||
| clorobiocin | ||
| cloxacillin | ||
| colistin | CST | |
| colistin A | ||
| colistin B | ||
| coumermycin A1 | ||
| cyclic thiazolyl peptide elfamycin | ||
| cycloserine | ||
| dalbavancin | ||
| dalfopristin | ||
| danofloxacin | ||
| daptomycin | DAP | |
| defensin | ||
| delafloxacin | ||
| demeclocycline | ||
| diaminopyrimidine | ||
| dibekacin | ||
| dicloxacillin | DCX | |
| dihydromocimycin | ||
| dirithromycin | DTM | |
| doripenem | DOR | |
| doxycycline | DOX | |
| edeine | ||
| edeine A | ||
| edeine B | ||
| edeine D | ||
| edeine F | ||
| efrotomycin | ||
| elfamycin | ||
| enacyloxin IIa | ||
| enoxacin | ENX | |
| enrofloxacin | ||
| eravacycline | ||
| ertapenem | ERT | |
| erythromycin | ERY | |
| ethambutol | ||
| ethionamide | ||
| factumycin | ||
| fidaxomicin | ||
| fleroxacin | FLE | |
| flomoxef | ||
| florfenicol | ||
| flucloxacillin | ||
| fluconazole | ||
| flucytosine | ||
| fluoroquinolone | ||
| fosfomycin | FOF | |
| fosfomycin-glucose-6-phosphate | ||
| fosmidomycin | ||
| furazolidone | ||
| fusidic acid | ||
| gamithromycin | ||
| ganefromycin | ||
| gatifloxacin | GAT | |
| gentamicin | GEN | |
| gentamicin B | ||
| gentamicin C | ||
| glycylcycline | ||
| gramicidin | ||
| gramicidin A | ||
| gramicidin B | ||
| gramicidin C | ||
| gramicidin D | ||
| gramicidin S | ||
| grepafloxacin | GRX | |
| griseoviridin | ||
| heneicomycin | ||
| hygromycin B | ||
| iclaprim | ||
| imipenem | IPM | |
| imipenem-relebactam | yes | |
| isavuconazole | ||
| isepamicin | ||
| isoniazid | ||
| isopenicillin N | ||
| itraconazole | ||
| josamycin | ||
| kanamycin | KAN | |
| kanamycin A | ||
| kasugamicin | ||
| kirromycin | ||
| kirrothricin | ||
| kitasamycin | ||
| levofloxacin | LVX | |
| lincomycin | ||
| lincosamide | ||
| linezolid | LZD | |
| lipopeptide antibiotic | ||
| lividomycin | ||
| lividomycin A | ||
| lividomycin B | ||
| lomefloxacin | LOM | |
| loracarbef | LOR | |
| madumycin II | ||
| mafenide | ||
| magainin | ||
| marbofloxacin | ||
| mecillinam | ||
| megalomycin | ||
| meropenem | MEM | |
| meropenem-vaborbactam | yes | |
| methicillin | MET, meticillin | |
| methymycin | ||
| metronidazole | ||
| mezlocillin | MEZ | |
| micafungin | ||
| midecamycin | ||
| minocycline | MIN | |
| moenomycin | ||
| moenomycin A1 | ||
| moxalactam | MOX | |
| moxifloxacin | MXF | |
| mupirocin | ||
| mycinamicin | ||
| nafcillin | NAF | |
| nalidixic acid | NAL | |
| narbomycin | ||
| neomycin | ||
| netilmicin | NET | |
| nicotinamide | ||
| niddamycin | ||
| nitrofurantoin | NIT | |
| norfloxacin | NOR | |
| novobiocin | ||
| ofloxacin | OFX | |
| oleandomycin | ||
| omadacycline | ||
| orbifloxacin | ||
| oritavancin | ||
| ostreogrycin B3 | ||
| oxacillin | OXA | |
| oxytetracycline | ||
| para-aminosalicylic acid | ||
| paromomycin | ||
| patricin A | ||
| patricin B | ||
| pefloxacin | ||
| penam | ||
| penicillin | PEN | |
| penicillin N | ||
| phenelfamycin A | ||
| phenelfamycin B | ||
| phenelfamycin C | ||
| phenelfamycin D | ||
| phenelfamycin E | ||
| phenelfamycin F | ||
| phenelfamycin G | ||
| phenelfamycin H | ||
| phenicol | ||
| phenoxymethylpenicillin | ||
| pikromycin | ||
| piperacillin | PIP | |
| piperacillin-sulbactam | yes | |
| piperacillin-tazobactam | TZP | yes |
| plazomicin | ||
| pleuromutilin | ||
| polymyxin | ||
| polymyxin B | PMB | |
| polymyxin B1 | ||
| polymyxin B2 | ||
| polymyxin B3 | ||
| polymyxin B4 | ||
| posaconazole | ||
| pradofloxacin | ||
| pristinamycin IA | ||
| pristinamycin IB | ||
| pristinamycin IIA | ||
| propicillin | ||
| prothionamide | ||
| pulvomycin | ||
| puromycin | ||
| pyrazinamide | ||
| quinupristin | ||
| quinupristin-dalfopristin | Q-D | |
| retapamulin | ||
| ribostamycin | ||
| rifabutin | RFB | |
| rifampin | RIF, rifaldazine, rifampicin | |
| rifamycin | ||
| rifapentine | RFP | |
| rifaximin | ||
| ristocetin | ||
| rosaramicin | ||
| roxithromycin | ||
| sisomicin | ||
| sparfloxacin | SPX | |
| spectinomycin | SPT | |
| spiramycin | ||
| streptogramin | ||
| streptogramin A antibiotic | ||
| streptogramin B antibiotic | ||
| streptomycin | STR | |
| streptothricin | ||
| sulbactam | SUL | |
| sulfacetamide | ||
| sulfadiazine | ||
| sulfadimethoxine | sulphadimethoxine | |
| sulfadimidine | ||
| sulfadoxine | ||
| sulfamethizole | ||
| sulfamethoxazole | ||
| sulfasalazine | ||
| sulfisoxazole | ||
| sulfonamide | ||
| sulopenem | ||
| sulphathiazole | ||
| surotomycin | ||
| synercid | ||
| tazobactam | TZB | |
| tedizolid | ||
| teicoplanin | TEC | |
| telavancin | ||
| telithromycin | TEL | |
| temocillin | ||
| tetracycline | TET | |
| tetroxoprim | ||
| thiamphenicol | ||
| thiostrepton | ||
| tiamulin | ||
| ticarcillin | TIC | |
| ticarcillin-clavulanic acid | TIM | yes |
| tigecycline | TGC | |
| tildipirosin | ||
| tilmicosin | ||
| timentin | ||
| tinidazole | ||
| tobramycin | TOB | |
| triclosan | ||
| trimethoprim | TMP | |
| trimethoprim-sulfamethoxazole | SXT, co-trimoxazole, cotrimoxazole | yes |
| trovafloxacin | TVA | |
| tuberactinomycin | ||
| tulathromycin | ||
| tunicamycin | ||
| tylosin | ||
| tyrothricin | ||
| unphenelfamycin | ||
| valnemulin | ||
| vancomycin | VAN | |
| verdamicin | ||
| vernamycin B-gamma | ||
| vernamycin C | ||
| vertilimicin | ||
| viomycin | ||
| virginiamycin S2 | ||
| voriconazole | ||
| zoliflodacin |