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. 2025 Jan:136:156317.
doi: 10.1016/j.phymed.2024.156317. Epub 2024 Dec 5.

Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-κB pathway

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Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-κB pathway

Yunfei Wei et al. Phytomedicine. 2025 Jan.

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory reactions. Asiaticoside (Asi) is a compound derived from Centella asiatica, possesses antioxidant, antiphlogistic, antifibrotic, as well as wound healing properties.

Purpose: The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.

Study design: Two versions of experimental models were constructed using free fatty acids (FFAs)-stimulated HepG2 cells along with high-fat diet (HFD)-incited NAFLD in mice.

Methods: The pivotal action of Nrf2 was then explored using Ml-385 or Nrf2-/- mice.

Results: The results indicated that Asi activated the Nrf2 to alleviate oxidative stress, inhibited the NF-κB to reduce the inflammatory response, and notably decreased lipid droplets and alleviated steatosis.

Conclusion: In conclusion, Asi demonstrates a potential to activate Nrf2 as well as inhibit the NF-κB pathway, there alleviate NAFLD.

Keywords: Asiaticoside; NAFLD; NF-κB; Nrf2.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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