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Review

Mahogany Seed

No authors listed
In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
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Review

Mahogany Seed

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Excerpt

Mahogany, Swietenia macrophylla, is a lofty fruit-bearing tree native to tropical areas of the Americas that is a valuable source of timber and also of herbal products made from its seeds, fruit (Skyfruit), leaves, stems, or bark. Recently, extracts of mahogany seeds have been reported to cause clinically apparent acute liver injury.

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References

    1. Zimmerman HJ. Unconventional drugs. Miscellaneous drugs and diagnostic chemicals. In, Zimmerman, HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott,1999: pp. 731-4.(Expert review of hepatotoxicity published in 1999; several herbal medications are discussed, but not mahogany seed).
    1. Dewanjee S, Maiti A, Das AK, Mandal SC, Dey SP. Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed. Fitoterapia. 2009;80:249-51.(Assessment of the hypoglycemic effects of an extract of mahogany seeds [swietenine] demonstrated reduction in fasting blood glucose in a streptozocin-treated rat model of diabetes). - PubMed
    1. Moghadamtousi SZ, Goh BH, Chan CK, Shabab T, Kadir HA. Biological activities and phytochemicals of Swietenia macrophylla King. Molecules. 2013;18:10465-83.(Phytochemical analysis of the components found in extracts from Swietenia macrophylla [Mahogany tree] demonstrated multiple limonoids including swietenine and related compounds as well as steroids, fatty acid esters, polyphenols, essential oils, coumarin, and lignan, with a summary of the various biologic activities described in in vivo studies). - PMC - PubMed
    1. Teschke R, Wolff A, Frenzel C, Schulze J, Eickhoff A. Herbal hepatotoxicity: a tabular compilation of reported cases. Liver Int 2012; 32: 1543-56.(A systematic compilation of all publications on the hepatotoxicity of specific herbal products identified 185 publications on 60 different herbs, herbal drugs and supplements but does not list or mention mahogany seed). - PubMed
    1. Navarro VJ, Seeff LB. Liver injury induced by herbal complementary and alternative medicine. Clin Liver Dis 2013; 17: 715-35.(Review of the epidemiology, regulatory status, diagnosis, pathogenesis and causes of liver injury from herbal products with specific discussion of conjugated linoleic acid, ephedra, germander, green tea, usnic acid, flavocoxid, aloe vera, chaparral, greater celandine, black cohosh, comfrey, kava, skullcap, valerian, noni juice, pennyroyal, and traditional herbal remedies; no mention of mahogany seed). - PubMed

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