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Review
. 2024 Jan 22;17(1):138.
doi: 10.3390/ph17010138.

Microbial Biosurfactants: Antimicrobial Activity and Potential Biomedical and Therapeutic Exploits

Patricia Puyol McKenna  1 , Patrick J Naughton  1 , James S G Dooley  1 , Nigel G Ternan  1 , Patrick Lemoine  2 , Ibrahim M Banat  3
Affiliations
Review

Microbial Biosurfactants: Antimicrobial Activity and Potential Biomedical and Therapeutic Exploits

Patricia Puyol McKenna et al. Pharmaceuticals (Basel). .

Abstract

The rapid emergence of multidrug-resistant pathogens worldwide has raised concerns regarding the effectiveness of conventional antibiotics. This can be observed in ESKAPE pathogens, among others, whose multiple resistance mechanisms have led to a reduction in effective treatment options. Innovative strategies aimed at mitigating the incidence of antibiotic-resistant pathogens encompass the potential use of biosurfactants. These surface-active agents comprise a group of unique amphiphilic molecules of microbial origin that are capable of interacting with the lipidic components of microorganisms. Biosurfactant interactions with different surfaces can affect their hydrophobic properties and as a result, their ability to alter microorganisms' adhesion abilities and consequent biofilm formation. Unlike synthetic surfactants, biosurfactants present low toxicity and high biodegradability and remain stable under temperature and pH extremes, making them potentially suitable for targeted use in medical and pharmaceutical applications. This review discusses the development of biosurfactants in biomedical and therapeutic uses as antimicrobial and antibiofilm agents, in addition to considering the potential synergistic effect of biosurfactants in combination with antibiotics. Furthermore, the anti-cancer and anti-viral potential of biosurfactants in relation to COVID-19 is also discussed.

Keywords: COVID-19; anti-cancer; antibiofilm; antibiotic resistance; biosurfactants.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Classification of biosurfactants including most prevalent producing microorganism.
Figure 2
Figure 2
Structure of biosurfactant micelles and mechanism of action in inhibition of biofilm formation on surfaces.
Figure 3
Figure 3
Structure of biosurfactant molecule and expected interaction with viral envelope. Mode of action relies on solubilization of the viral membrane in addition to the encapsulation of viral fragments.
Figure 4
Figure 4
Schematic representation of the effects of biosurfactants on cancerous cells.
See this image and copyright information in PMC

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