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Case Reports
. 2022 Jul 19;14(7):e27005.
doi: 10.7759/cureus.27005. eCollection 2022 Jul.

Drug-Induced Liver Injury From Sacubitril-Valsartan Versus a Single Dose of Acarbose

Supraja Achuthanandan  1 , Amit Dhaliwal  1 , Ravikaran Patti  1
Affiliations
Case Reports

Drug-Induced Liver Injury From Sacubitril-Valsartan Versus a Single Dose of Acarbose

Supraja Achuthanandan et al. Cureus. .

Abstract

Numerous known medications can induce liver injury. Sacubitril-valsartan was approved by the Food and Drug Administration in 2015 for use in patients with chronic heart failure to reduce the rate of cardiovascular death and hospitalizations related to heart failure. There are yet to be any reported cases of drug-induced liver injury secondary to sacubitril-valsartan use. Acarbose is well known to be associated with liver failure, but typically liver injury occurs months after initiation of therapy. Here, we report the case of a 76-year-old woman who developed acute liver failure after one month of sacubitril-valsartan use and one day after being prescribed acarbose.

Keywords: acarbose; acute liver failure (alf); drug-induced acute liver failure; drug-induced liver injury (dili); entrestro; sacubitril-valsartan.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Computed tomography without contrast.
The liver is noted to be within normal limits in regards to size and contour, without the presence of any focal masses.
Figure 2
Figure 2. Ultrasound of the liver.
(A) Echogenic liver with normal contour, measuring 12 cm. (B) The common bile duct measuring 7 mm. (C) A patent portal vein.
See this image and copyright information in PMC

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