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Review
. 2021 Jun;53(6):801-812.
doi: 10.1007/s00726-021-02990-0. Epub 2021 May 5.

Biochemistry of plants N-heterocyclic non-protein amino acids

Vishal Singh Negi  1 , Archana Pal  1 , Dulal Borthakur  2
Affiliations
Review

Biochemistry of plants N-heterocyclic non-protein amino acids

Vishal Singh Negi et al. Amino Acids. 2021 Jun.

Abstract

Plants catalyze the biosynthesis of a large number of non-protein amino acids, which are usually toxic for other organisms. In this review, the chemistry and metabolism of N-heterocyclic non-protein amino acids from plants are described. These N-heterocyclic non-protein amino acids are composed of β-substituted alanines and include mimosine, β-pyrazol-1-yl-L-alanine, willardiine, isowillardiine, and lathyrine. These β-substituted alanines consisted of an N-heterocyclic moiety and an alanyl side chain. This review explains how these individual moieties are derived from their precursors and how they are used as the substrate for biosynthesizing the respective N-heterocyclic non-protein amino acids. In addition, known catabolism and possible role of these non-protein amino acids in the actual host is explained.

Keywords: Cysteine synthase; Isowillardiine; Lathyrine; Mimosine; OAS; Serine; Willardiine; β–PA.

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