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Review

Belantamab Mafodotin

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
Free Books & Documents
Review

Belantamab Mafodotin

No authors listed.
Free Books & Documents

Excerpt

Belantamab mafodotin has been discontinued in the United States. No information is available on the clinical use of belantamab mafodotin during breastfeeding. Because belantamab is a large protein molecule with a molecular weight of 152,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] However, belantamab is conjugated with the small-molecule toxin, mafodotin, which might be excreted into milk and absorbed by the infant. Because of the potential for serious adverse reactions in the breastfed infant, the manufacturer recommends that breastfeeding be discontinued during therapy and for 3 months after the last dose.

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References

    1. Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 - DOI
    1. Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. - PubMed

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