Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar;25(1):13-26.
doi: 10.1007/s10911-020-09445-4. Epub 2020 Feb 21.

Ret Receptor Has Distinct Alterations and Functions in Breast Cancer

Albana Gattelli  1   2 , Nancy E Hynes  3   4 , Ignacio E Schor  5   6 , Sabrina A Vallone  5   7
Affiliations
Review

Ret Receptor Has Distinct Alterations and Functions in Breast Cancer

Albana Gattelli et al. J Mammary Gland Biol Neoplasia. 2020 Mar.

Abstract

Ret receptor tyrosine kinase is a proto-oncogene that participates in development of various cancers. Several independent studies have recently identified Ret as a key player in breast cancer. Although Ret overexpression and function have been under investigation, mainly in estrogen receptor positive breast cancer, a more comprehensive analysis of the impact of recurring Ret alterations in breast cancer is needed. This review consolidates the current knowledge of Ret alterations and their potential effects in breast cancer. We discuss and integrate data on Ret changes in different breast cancer subtypes and potential function in progression, as well as the participation of distinct Ret network signaling partners in these processes. We propose that it will be essential to define a shared molecular feature of tumors with alteration in Ret receptor, be this at the genetic level or via overexpression in order to design effective therapies to target the Ret pathway. Here we review experimental evidence from basic research and pre-clinical studies concentrating on Ret alterations as potential biomarkers for recurrence, and we discuss the possibility that targeting the Ret pathway might in the future become a treatment for breast cancer.

Keywords: Breast tumors; ER +; Endocrine resistance; Rearrangements; Ret.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. PLoS One. 2009 Jul 03;4(7):e6146 - PubMed
    1. Ann Surg Oncol. 2015 Dec;22(13):4287-94 - PubMed
    1. Oncogene. 1995 Sep 21;11(6):1207-10 - PubMed
    1. Nature. 2012 May 16;486(7403):400-4 - PubMed
    1. Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2): - PubMed

Publication types

LinkOut - more resources