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. 2019 Sep;28(5):e13076.
doi: 10.1111/ecc.13076. Epub 2019 May 2.

Health-related quality of life in long-term survivors with localised prostate cancer by therapy-Results from a population-based study

Salome Adam  1   2 , Lena Koch-Gallenkamp  3 , Heike Bertram  4 , Andrea Eberle  5 , Bernd Holleczek  6 , Ron Pritzkuleit  7 , Mechthild Waldeyer-Sauerland  8 , Annika Waldmann  8   9 , Sylke Ruth Zeissig  10 , Sabine Rohrmann  2 , Hermann Brenner  3   11   12 , Volker Arndt  1
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Health-related quality of life in long-term survivors with localised prostate cancer by therapy-Results from a population-based study

Salome Adam et al. Eur J Cancer Care (Engl). 2019 Sep.

Abstract

Objective: Several therapies for localised prostate cancer (PC) are available; all yield similar survival rates. However, each therapy has significant side effects that can influence patients' health-related quality of life (HRQoL) in the long run.

Methods: The study sample included 911 survivors with localised PC, 5-15 years post-diagnosis who were identified from the population-based CAESAR + study in Germany. HRQoL was assessed using the EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. The association between type of therapy and HRQoL was assessed with multivariable linear regression and global F-test adjusting for age, time since diagnosis and comorbidities.

Results: Overall, survivors treated with radical prostatectomy (RP) or radiotherapy (RT) alone reported the best HRQoL and the lowest symptom burden. Conversely, survivors treated with androgen deprivation therapy (ADT) (& RP/RT) or RP & RT (in combination) reported the worst HRQoL and the highest symptom burden. Significant differences among treatment groups in HRQoL were found for global health status (p = 0.041), social functioning (p = 0.007), urinary symptoms (p = 0.035), bowel symptoms (p = 0.017) and hormonal treatment-related symptoms (p < 0.001) among other symptoms.

Conclusions: Long-term localised PC survivors formerly treated with a combination of RP and RT or with ADT report poorer HRQoL and more symptoms than patients treated with either RP or RT alone.

Keywords: health-related quality of life; prostate cancer; therapy; well-being.

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