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Review
. 2017 Aug;18(8):498-512.
doi: 10.1038/nrg.2017.21. Epub 2017 May 8.

The origin of Metazoa: a unicellular perspective

Arnau Sebé-Pedrós  1 , Bernard M Degnan  2 , Iñaki Ruiz-Trillo  3   4   5
Affiliations
Review

The origin of Metazoa: a unicellular perspective

Arnau Sebé-Pedrós et al. Nat Rev Genet. 2017 Aug.

Abstract

The first animals evolved from an unknown single-celled ancestor in the Precambrian period. Recently, the identification and characterization of the genomic and cellular traits of the protists most closely related to animals have shed light on the origin of animals. Comparisons of animals with these unicellular relatives allow us to reconstruct the first evolutionary steps towards animal multicellularity. Here, we review the results of these investigations and discuss their implications for understanding the earliest stages of animal evolution, including the origin of metazoan genes and genome function.

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References

    1. Curr Biol. 2010 Dec 21;20(24):2217-22 - PubMed
    1. Nat Rev Genet. 2015 Dec;16(12):716-26 - PubMed
    1. Nat Rev Genet. 2008 Nov;9(11):868-82 - PubMed
    1. Nat Genet. 2012 Jan 08;44(2):148-56 - PubMed
    1. Nature. 2008 Feb 14;451(7180):783-8 - PubMed

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