1,3-β-D-Glucan contamination of common antimicrobials

doi:10.1093/jac/dkv419

. 2016 Apr;71(4):913-5.

doi: 10.1093/jac/dkv419. Epub 2015 Dec 13.

1,3-β-D-Glucan contamination of common antimicrobials

B Liss¹, O A Cornely², D Hoffmann³, V Dimitriou⁴, H Wisplinghoff⁵

Affiliations

¹ Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany Centre for Integrated Oncology CIO KölnBonn, University of Cologne, Cologne, Germany blasius.liss@uk-koeln.de.
² Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany Centre for Integrated Oncology CIO KölnBonn, University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Clinical Trials Centre Cologne, ZKS Köln, BMBF 01KN1106, University of Cologne, Cologne, Germany German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.
³ Wisplinghoff Laboratories, Cologne, Germany.
⁴ German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.
⁵ Wisplinghoff Laboratories, Cologne, Germany Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

PMID: 26668235
DOI: 10.1093/jac/dkv419

1,3-β-D-Glucan contamination of common antimicrobials

B Liss et al. J Antimicrob Chemother. 2016 Apr.

. 2016 Apr;71(4):913-5.

doi: 10.1093/jac/dkv419. Epub 2015 Dec 13.

Authors

B Liss¹, O A Cornely², D Hoffmann³, V Dimitriou⁴, H Wisplinghoff⁵

Affiliations

¹ Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany Centre for Integrated Oncology CIO KölnBonn, University of Cologne, Cologne, Germany blasius.liss@uk-koeln.de.
² Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany Centre for Integrated Oncology CIO KölnBonn, University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Clinical Trials Centre Cologne, ZKS Köln, BMBF 01KN1106, University of Cologne, Cologne, Germany German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.
³ Wisplinghoff Laboratories, Cologne, Germany.
⁴ German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.
⁵ Wisplinghoff Laboratories, Cologne, Germany Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

PMID: 26668235
DOI: 10.1093/jac/dkv419

Abstract

Background: 1,3-β-D-Glucan (BDG) is a fungal cell wall constituent used in the diagnosis of invasive fungal infections. BDG testing, although endorsed by the European Organization for Research and Treatment of Cancer, suffers from limited specificity. False-positive results have been linked to haemodialysis membranes, blood products, antineoplastic agents and antimicrobial use.

Objectives: The aim of this study was to determine whether false-positive BDG results in the context of antimicrobial use are caused by BDG present in infusion solutions.

Methods: We obtained 35 antimicrobial drugs (30 antibiotics and 5 antifungals) and analysed their BDG content using two different assays.

Results: Twenty-five antimicrobials (20 antibiotics and all the tested antifungals) contained enough BDG to trigger a positive test. Depending on the substance, BDG varied between 9 and 2818 pg/mL.

Conclusions: A majority of the available antimicrobial substances contained BDG, potentially limiting the utility of BDG testing in the context of prior exposure to these drugs. As the cumulative effects of repeated BDG exposure are unknown, efforts to reduce contamination should be considered.

© The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PubMed Disclaimer

Comment in

Comment on: 1,3-β-d-Glucan contamination of common antimicrobials.
Finkelman MA. Finkelman MA. J Antimicrob Chemother. 2016 Oct;71(10):2996-7. doi: 10.1093/jac/dkw237. Epub 2016 Jun 21. J Antimicrob Chemother. 2016. PMID: 27334662 No abstract available.
1,3-β-d-Glucan contamination of common antimicrobials-authors' response.
Liss B, Cornely OA, Hoffmann D, Dimitriou V, Wisplinghoff H. Liss B, et al. J Antimicrob Chemother. 2016 Oct;71(10):2997-9. doi: 10.1093/jac/dkw299. Epub 2016 Jul 27. J Antimicrob Chemother. 2016. PMID: 27494926 No abstract available.

Cited by

Detection of (1→3)-β-d-Glucan in Eumycetoma Patients.
Fahal AH, Finkelman MA, Zhang Y, van de Sande WW. Fahal AH, et al. J Clin Microbiol. 2016 Oct;54(10):2614-7. doi: 10.1128/JCM.01478-16. Epub 2016 Jul 20. J Clin Microbiol. 2016. PMID: 27440815 Free PMC article.
(1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial.
Bloos F, Held J, Kluge S, Simon P, Kogelmann K, de Heer G, Kuhn SO, Jarczak D, Motsch J, Hempel G, Weiler N, Weyland A, Drüner M, Gründling M, Meybohm P, Richter D, Jaschinski U, Moerer O, Günther U, Schädler D, Weiss R, Putensen C, Castellanos I, Kurzai O, Schlattmann P, Cornely OA, Bauer M, Thomas-Rüddel D; SepNet Study Group. Bloos F, et al. Intensive Care Med. 2022 Jul;48(7):865-875. doi: 10.1007/s00134-022-06733-x. Epub 2022 Jun 16. Intensive Care Med. 2022. PMID: 35708758 Free PMC article. Clinical Trial.
Efficacy of Cerebrospinal Fluid Beta-d-Glucan Diagnostic Testing for Fungal Meningitis: a Systematic Review.
Davis C, Wheat LJ, Myint T, Boulware DR, Bahr NC. Davis C, et al. J Clin Microbiol. 2020 Mar 25;58(4):e02094-19. doi: 10.1128/JCM.02094-19. Print 2020 Mar 25. J Clin Microbiol. 2020. PMID: 31996446 Free PMC article.
Detection of Beta-Glucan Contamination in Nanotechnology-Based Formulations.
Neun BW, Cedrone E, Potter TM, Crist RM, Dobrovolskaia MA. Neun BW, et al. Molecules. 2020 Jul 24;25(15):3367. doi: 10.3390/molecules25153367. Molecules. 2020. PMID: 32722261 Free PMC article. Review.
Effects of Different Container Types on (1→3)-β-D-glucan Recovery.
Burgmaier L, Illes B, Leiss M, Avci-Adali M, Reich J. Burgmaier L, et al. Molecules. 2023 Oct 4;28(19):6931. doi: 10.3390/molecules28196931. Molecules. 2023. PMID: 37836774 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Silverchair Information Systems
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

1,3-β-D-Glucan contamination of common antimicrobials

Affiliations

1,3-β-D-Glucan contamination of common antimicrobials

Authors

Affiliations

Abstract

Comment in

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Research Materials

Abstract

Comment in

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Research Materials