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Review
. 2015 Sep 25;2015(9):CD007569.
doi: 10.1002/14651858.CD007569.pub3.

Interventions to enhance return-to-work for cancer patients

Angela G E M de Boer  1 , Tyna K Taskila, Sietske J Tamminga, Michael Feuerstein, Monique H W Frings-Dresen, Jos H Verbeek
Affiliations
Review

Interventions to enhance return-to-work for cancer patients

Angela G E M de Boer et al. Cochrane Database Syst Rev. .

Update in

Abstract

Background: Cancer patients are 1.4 times more likely to be unemployed than healthy people. Therefore it is important to provide cancer patients with programmes to support the return-to-work (RTW) process. This is an update of a Cochrane review first published in 2011.

Objectives: To evaluate the effectiveness of interventions aimed at enhancing RTW in cancer patients compared to alternative programmes including usual care or no intervention.

Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, in the Cochrane Library Issue 3, 2014), MEDLINE (January 1966 to March 2014), EMBASE (January 1947 to March 2014), CINAHL (January 1983 to March, 2014), OSH-ROM and OSH Update (January 1960 to March, 2014), PsycINFO (January 1806 to 25 March 2014), DARE (January 1995 to March, 2014), ClinicalTrials.gov, Trialregister.nl and Controlled-trials.com up to 25 March 2014. We also examined the reference lists of included studies and selected reviews, and contacted authors of relevant studies.

Selection criteria: We included randomised controlled trials (RCTs) of the effectiveness of psycho-educational, vocational, physical, medical or multidisciplinary interventions enhancing RTW in cancer patients. The primary outcome was RTW measured as either RTW rate or sick leave duration measured at 12 months' follow-up. The secondary outcome was quality of life.

Data collection and analysis: Two review authors independently assessed trials for inclusion, assessed the risk of bias and extracted data. We pooled study results we judged to be clinically homogeneous in different comparisons reporting risk ratios (RRs) with 95% confidence intervals (CIs). We assessed the overall quality of the evidence for each comparison using the GRADE approach.

Main results: Fifteen RCTs including 1835 cancer patients met the inclusion criteria and because of multiple arms studies we included 19 evaluations. We judged six studies to have a high risk of bias and nine to have a low risk of bias. All included studies were conducted in high income countries and most studies were aimed at breast cancer patients (seven trials) or prostate cancer patients (two trials).Two studies involved psycho-educational interventions including patient education and teaching self-care behaviours. Results indicated low quality evidence of similar RTW rates for psycho-educational interventions compared to care as usual (RR 1.09, 95% CI 0.88 to 1.35, n = 260 patients) and low quality evidence that there is no difference in the effect of psycho-educational interventions compared to care as usual on quality of life (standardised mean difference (SMD) 0.05, 95% CI -0.2 to 0.3, n = 260 patients). We did not find any studies on vocational interventions. In one study breast cancer patients were offered a physical training programme. Low quality evidence suggested that physical training was not more effective than care as usual in improving RTW (RR 1.20, 95% CI 0.32 to 4.54, n = 28 patients) or quality of life (SMD -0.37, 95% CI -0.99 to 0.25, n = 41 patients).Seven RCTs assessed the effects of a medical intervention on RTW. In all studies a less radical or functioning conserving medical intervention was compared with a more radical treatment. We found low quality evidence that less radical, functioning conserving approaches had similar RTW rates as more radical treatments (RR 1.04, 95% CI 0.96 to 1.09, n = 1097 patients) and moderate quality evidence of no differences in quality of life outcomes (SMD 0.10, 95% CI -0.04 to 0.23, n = 1028 patients).Five RCTs involved multidisciplinary interventions in which vocational counselling was combined with patient education, patient counselling, and biofeedback-assisted behavioral training or physical exercises. Moderate quality evidence showed that multidisciplinary interventions involving physical, psycho-educational and vocational components led to higher RTW rates than care as usual (RR 1.11, 95% CI 1.03 to 1.16, n = 450 patients). We found no differences in the effect of multidisciplinary interventions compared to care as usual on quality of life outcomes (SMD 0.03, 95% CI -0.20 to 0.25, n = 316 patients).

Authors' conclusions: We found moderate quality evidence that multidisciplinary interventions enhance the RTW of patients with cancer.

PubMed Disclaimer

Conflict of interest statement

Angela de Boer: I am an author of Tamminga 2013.

Tyna Taskila: None known.

Sietske Tamminga: I am an author of Tamminga 2013.

Michael Feuerstein: I have received consultancy fees from Paradigm Health Corp and travel support and royalties from Springer but these are not related to the topic of this Cochrane review. Neither the grant I currently have nor the retirement investments I have (managed by TIAA‐CREF) are also not related to the topic of this Cochrane review.

Monique Frings‐Dresen: I am an author of Tamminga 2013.

Jos Verbeek: I am an author of Tamminga 2013 and I am employed by the Finnish Institute of Occupational Health to coordinate the Cochrane Work Review Group.

Figures

1
1
PRISMA flow diagram of reference selection and study inclusion.
2
2
'Risk of bias' graph: review authors' judgements about each 'Risk of bias' item presented as percentages across all included studies.
3
3
'Risk of bias' summary: review authors' judgements about each 'Risk of bias' item for each included study.
4
4
Funnel plot of comparison: 4 Medical function conserving versus Medical more radical‐RCTs, outcome: 4.1 RTW.
1.1
1.1. Analysis
Comparison 1 Psycho‐educational versus Care as usual, Outcome 1 RTW.
1.2
1.2. Analysis
Comparison 1 Psycho‐educational versus Care as usual, Outcome 2 QoL.
2.1
2.1. Analysis
Comparison 2 Physical versus Care as usual, Outcome 1 RTW.
2.2
2.2. Analysis
Comparison 2 Physical versus Care as usual, Outcome 2 QoL.
3.1
3.1. Analysis
Comparison 3 Medical function conserving versus Medical more radical, Outcome 1 RTW.
3.2
3.2. Analysis
Comparison 3 Medical function conserving versus Medical more radical, Outcome 2 QoL.
4.1
4.1. Analysis
Comparison 4 Multidisciplinary physical, psycho‐educational and/or vocational interventions versus Care as usual, Outcome 1 RTW.
4.2
4.2. Analysis
Comparison 4 Multidisciplinary physical, psycho‐educational and/or vocational interventions versus Care as usual, Outcome 2 QoL.
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References

References to studies included in this review

Ackerstaff 2009 {published and unpublished data}
    1. Ackerstaff AH, Balm AJM, Rasch CRN, Boer JP, Wiggenraad R, Rietveld DHF, et al. First‐year quality of life assessment of an intra‐arterial (radplat) versus intravenous chemoradiation phase III trial. Head & Neck 2009;31(1):77‐84. - PubMed
Berglund 1994 {published data only}
    1. Berglund G, Bolund C, Gustafsson UL, Sjödén P‐O. One‐year follow‐up of the 'Starting Again' group rehabilitation programme for cancer patients. European Journal of Cancer 1994;30A(12):1744‐51. - PubMed
Burgio 2006 {published data only}
    1. Burgio KL, Goode PS, Urban DA, Umlauf MG, Locher JL, Bueschen A, et al. Preoperative biofeedback assisted behavioral training to decrease post‐prostatectomy incontinence: a randomized, controlled study. Journal of Urology 2006;175(1):196‐201. - PubMed
Emmanouilidis 2009 {published data only}
    1. Emmanouilidis N, Müller JA, Jäger MD, Kaaden S, Helfritz FA, Güner Z, et al. Surgery and radioablation therapy combined: introducing a 1‐week‐condensed procedure bonding total thyroidectomy and radioablation therapy with recombinant human TSH. European Journal of Endocrinology 2009;161(5):763‐9. - PubMed
Friedrichs 2010 {published data only}
    1. Friedrichs B, Tichelli A, Bacigalupo A, Russell NH, Ruutu T, Shapira MY, et al. Long‐term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial. The Lancet Oncology 2010;11(4):331‐8. - PubMed
Hillman 1998 {published data only}
    1. Hillman RE, Walsh MJ, Wolf GT, Fisher SG, Hong WK. Functional outcomes following treatment for advanced laryngeal cancer. Part I‐‐Voice preservation in advancedlaryngeal cancer. Part II‐‐Laryngectomy rehabilitation: the state of the art in the VA System. Research Speech‐Language Pathologists. Department of Veterans Affairs Laryngeal Cancer Study Group. Annals of Otology, Rhinology and Laryngology 1998;172:1‐27. - PubMed
Hubbard 2013 {published data only}
    1. Hubbard G, Gray NM, Ayansina D, Evans JM, Kyle RG. Case management vocational rehabilitation for women with breast cancer after surgery: a feasibility study incorporating a pilot randomised controlled trial. Trials 2013;14:175. - PMC - PubMed
Johnsson 2007 {published data only}
    1. Johnsson A, Fornander T, Olsson M, Nystedt M, Johansson H, Rutqvist LE. Factors associated with return to work after breast cancer treatment. Acta Oncologica 2007;46(1):90‐6. - PubMed
Kornblith 2009 {published data only}
    1. Kornblith AB, Huang HQ, Walker JL, Spirtos NM, Rotmensch J, Cella D. Quality of life patients with endometrial cancer undergoing laparoscopic international federation of gynecology and obstetrics staging compared with laparotomy: a Gynecologic Oncology Group study. Journal of Clinical Oncology 2009;27(32):5337‐42. - PMC - PubMed
Lee 1992 {published data only}
    1. Lee MS, Love SB, Mitchell JB, Parker EM, Rubens RD, Watson JP, et al. Mastectomy or conservation for early breast cancer: psychological morbidity. European Journal of Cancer 1992;28A(8‐9):1340‐4. - PubMed
Lepore 2003 {published data only}
    1. Lepore SJ, Helgeson VS, Eton DT, Schulz R. Improving quality of life in men with prostate cancer: a randomized controlled trial of group education interventions. Health Psychology 2003;22(5):443‐52. - PMC - PubMed
Maguire 1983 {published data only}
    1. Maguire P, Brooke M, Tait A, Thomas C, Sellwood R. The effect of counselling on physical disability and social recovery after mastectomy. Clinical Oncology 1983;9(4):319‐24. - PubMed
Purcell 2011 {published data only}
    1. Purcell A, Fleming J, Burmeister B, Bennett S, Haines T. Is education an effective management strategy for reducing cancer‐related fatigue?. Supportive Care in Cancer 2011;19(9):1429‐39. - PubMed
Rogers 2009 {published and unpublished data}
    1. Rogers LQ, Hopkins‐Pryce P, Vicari S, Pamenter R, Courneya KS, Markwell S, et al. A randomized trial to increase physical activity in breast cancer survivors. Medical Science Sports Exercises 2009;41(4):935‐46. - PubMed
Tamminga 2013 {published and unpublished data}
    1. Tamminga SJ, Verbeek JH, Bos MM, Fons G, Kitzen JJ, Plaisier PW, et al. Effectiveness of a hospital‐based work support intervention for female cancer patients ‐ a multi‐centre randomised controlled trial. PLoS One 2013;8(5):e63271. - PMC - PubMed

References to studies excluded from this review

Adamsen 2009 {published data only}
    1. Adamsen L, Quist M, Andersen C, Møller T, Herrstedt J, Kronborg D, et al. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ 2009;339:b3410. - PMC - PubMed
Berglund 1993 {published data only}
    1. Berglund G, Bolund C, Gustavsson UL, Sjödén PO. Starting again‐‐a comparison study of a group rehabilitation program for cancer patients. Acta Oncologica 1993;32(1):15‐21. - PubMed
Berglund 2003 {published data only}
    1. Berglund G, Petersson LM, Eriksson KR, Häggman M. "Between men": patient perceptions and priorities in a rehabilitation program for men with prostate cancer. Patient Education and Counselling 2003;49(3):285‐92. - PubMed
Bertheussen 2012 {published data only}
    1. Bertheussen GF, Kaasa S, Hokstad A, Sandmæl JA, Helbostad JL, Salvesen Ø, et al. Feasibility and changes in symptoms and functioning following inpatient cancer rehabilitation. Acta Oncologica 2012;51(8):1070‐80. - PubMed
Bird 2010 {published data only}
    1. Bird L, Arthur A, Niblock T, Stone R, Watson L, Cox K. Rehabilitation programme after stem cell transplantation: randomized controlled trial. Journal of Advanced Nursing 2010;66(3):607‐15. - PubMed
Bloom 2008 {published data only}
    1. Bloom JR, Stewart SL, D'Onofrio CN, Luce J, Banks PJ. Addressing the needs of young breast cancer survivors at the 5 year milestone: can a short‐term, low intensity intervention produce change?. Journal of Cancer Survivorship 2008;2(3):190‐204. - PubMed
Borget 2007 {published data only}
    1. Borget I, Corone C, Nocaudie M, Allyn M, Iacobelli S, Schlumberger M, et al. Sick leave for follow‐up control in thyroid cancer patients: comparison between stimulation with Thyrogen and thyroid hormone withdrawal. European Journal of Endocrinology 2007;156(5):531‐8. - PubMed
Böttcher 2013 {published data only}
    1. Böttcher HM, Steimann M, Ullrich A, Rotsch M, Zurborn KH, Koch U, et al. Evaluation of a vocationally oriented concept within inpatient oncological rehabilitation [Evaluation eines berufsbezogenen Konzepts im Rahmen der stationären onkologischen Rehabilitation]. Die Rehabilitation 2013;52(5):329‐36. - PubMed
Budin 2008 {published data only}
    1. Budin WC, Hoskins CN, Haber J, Sherman DW, Maislin G, Cater JR, et al. Breast cancer: education, counseling, and adjustment among patients and partners: a randomized clinical trial. Nursing Research 2008;57(3):199‐213. - PubMed
Burak 2002 {published data only}
    1. Burak J, Hollenbeck ST, Zervos EE, Hock KL, Kemp LC, Young DC. Sentinel lymph node biopsy results in less postoperative morbidity compared with axillary lymph node dissection for breast cancer. American Journal of Surgery 2002;183(1):23‐7. - PubMed
Bürger 2011 {published data only}
    1. Bürger W, Streibelt M. Who benefits from stepwise occupational reintegration provided under the statutory pension insurance scheme? [Wer profitiert von Stufenweiser Wiedereingliederung in Trägerschaft der gesetzlichen Rentenversicherung?]. Die Rehabilitation 2011;50(3):178‐85. - PubMed
Cadmus‐Bertram 2013 {published data only}
    1. Cadmus‐Bertram L, Littman AJ, Ulrich CM, Stovall R, Ceballos RM, McGregor BA, et al. Predictors of adherence to a 26‐week viniyoga intervention among post‐treatment breast cancer survivors. Journal of Alternative and Complementary Medicine 2013;19(9):751‐8. - PMC - PubMed
Cain 1986 {published data only}
    1. Cain EN, Kohorn EI, Quinlan DM, Latimer K, Schwartz PE. Psychological benefits of a cancer support group. Cancer 1986;57(1):183‐9. - PubMed
Capone 1980 {published data only}
    1. Capone MA, Good RS, Westie KS, Jacobson AF. Psychosocial rehabilitation of gynecologic oncology patients. Archives of Physical Medical and Rehabilitation 1980;61(3):128‐32. - PubMed
Chan 2005 {published data only}
    1. Chan YM, Lee PW, Fong DY, Fung AS, Wu LY, Choi AY, et al. Effect of individual psychological intervention in Chinese women with gynecologic malignancy: a randomized controlled trial. Journal of Clinical Oncology 2005;23(22):4913‐24. - PubMed
Cherrier 2013 {published data only}
    1. Cherrier MM, Anderson K, David D, Higano CS, Gray H, Church A, et al. A randomized trial of cognitive rehabilitation in cancer survivors. Life Sciences 2013;93(17):617‐22. - PMC - PubMed
Cho 2006 {published data only}
    1. Cho OH, Yoo YS, Kim NC. Efficacy of comprehensive group rehabilitation for women with early breast cancer in South Korea. Nursing Health Science 2006;8(3):140‐6. - PubMed
Egan 2013 {published data only}
    1. Egan MY, McEwen S, Sikora L, Chasen M, Fitch M, Eldred S. Rehabilitation following cancer treatment. Disability and Rehabilitation 2013;35(26):2245‐58. - PubMed
Emmanouilidis 2013 {published data only}
    1. Emmanouilidis N, Schrem H, Winkler M, Klempnauer J, Scheumann GF. Long‐term results after treatment of very low‐, low‐, and high‐risk thyroid cancers in a combined setting of thyroidectomy and radio ablation therapy in euthyroidism. International Journal of Endocrinology 2013;2013:769473. - PMC - PubMed
Eyigor 2010 {published data only}
    1. Eyigor S, Karapolat H, Yesil H, Uslu R, Durmaz B. Effects of pilates exercises on functional capacity, flexibility, fatigue, depression and quality of life in female breast cancer patients: a randomized controlled study. European Journal of Physical and Rehabilitation Medicine 2010;46(4):481‐7. - PubMed
Fassoulaki 2000 {published data only}
    1. Fassoulaki A, Sarantopoulos C, Melemeni A, Hogan Q. EMLA reduces acute and chronic pain after breast surgery for cancer. Regional Anesthesia and Pain Medicine 2000;25(4):350‐5. - PubMed
Fors 2011 {published data only}
    1. Fors EA, Bertheussen GF, Thune I, Juvet LK, Elvsaas IK, Oldervoll L, et al. Psychosocial interventions as part of breast cancer rehabilitation programs? Results from a systematic review. Psychooncology 2011;20(9):909‐18. - PubMed
Gordon 1980 {published data only}
    1. Gordon WA, Freidenbergs I, Diller L, Hibbard M, Wolf C, Levine L, et al. Efficacy of psychosocial intervention with cancer patients. Journal of Consulting and Clinical Psychology 1980;48(6):743‐59. - PubMed
Gordon 2005 {published and unpublished data}
    1. Gordon LG, Scuffham P, Battistutta D, Graves N, Tweeddale M, Newman B. A cost‐effectiveness analysis of two rehabilitation support services for women with breast cancer. Breast Cancer Research and Treatment 2005;94(2):123‐33. - PubMed
Greer 1992 {published data only}
    1. Greer S, Moorey S, Baruch JD, Watson M, Robertson BM, Mason A, et al. Adjuvant psychological therapy for patients with cancer: a prospective randomised trial. BMJ 1992;304(6828):675‐80. - PMC - PubMed
Griffith 2009 {published data only}
    1. Griffith K, Wenzel J, Shang J, Thompson C, Stewart K, Mock V. Impact of a walking intervention on cardiorespiratory fitness, self‐reported physical function, and pain in patients undergoing treatment for solid tumors. Cancer 2009;115(20):4874‐84. - PMC - PubMed
Harrison‐Paul 2006 {published data only}
    1. Harrison‐Paul J, Drummond AER. A randomised controlled trial of occupational therapy in oncology: challenges in conducting a pilot study. British Journal of Occupational Therapy 2006;69(3):130‐3.
Hartmann 2007 {published data only}
    1. Hartmann U, Muche R, Reuss‐Borst M. Effects of a step‐by‐step inpatient rehabilitation programme on quality of life in breast cancer patients. A prospective randomised study. Onkologie 2007;30(4):177‐82. - PubMed
Hegel 2011 {published data only}
    1. Hegel MT, Lyons KD, Hull JG, Kaufman P, Urquhart L, Li Z, et al. Feasibility study of a randomized controlled trial of a telephone‐delivered problem‐solving‐occupational therapy intervention to reduce participation restrictions in rural breast cancer survivors undergoing chemotherapy. Psychooncology 2011;20(10):1092‐101. - PMC - PubMed
Heim 2007 {published data only}
    1. Heim ME, Malsburg ML, Niklas A. Randomized controlled trial of a structured training program in breast cancer patients with tumor‐related chronic fatigue. Onkologie 2007;30(8‐9):429‐34. - PubMed
Høybye 2010 {published data only}
    1. Høybye MT, Dalton SO, Deltour I, Bidstrup PE, Frederiksen K, Johansen C. Effect of Internet peer‐support groups on psychosocial adjustment to cancer: a randomised study. British Journal of Cancer 2010;102(9):1348‐54. - PMC - PubMed
Janson 2005 {published data only}
    1. Janson M, Carlsson P, Haglind E, Anderberg B. Data validation in an economic evaluation of surgery for colon cancer. International Journal of Technology Assessment in Health Care 2005;21(2):246‐52. - PubMed
Jiang 2009 {published data only}
    1. Jiang J, Zheng X, Qin J, Zheng M, Mao Q, Zhang Z, et al. Health‐related quality of life after hand‐assisted laparoscopic and open radical nephrectomies of renal cell carcinoma. International Urolology and Nephrology 2009;41(1):23‐7. - PubMed
Jones 2005 {published and unpublished data}
    1. Jones WG, Fossa SD, Mead GM, Roberts JT, Sokal M, Horwich A, et al. Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I Testicular Seminoma: a report on Medical Research Council Trial TE18, European Organisation for the Research and Treatment of Cancer Trial 30942 (ISRCTN18525328). Journal of Clinical Oncology 2005;23(6):1200‐8. - PubMed
Jørgensen 2009 {published data only}
    1. Jørgensen IL, Frederiksen K, Boesen E, Elsass P, Johansen C. An exploratory study of associations between illness perceptions and adjustment and changes after psychosocial rehabilitation in survivors of breast cancer. Acta Oncologica 2009;48(8):1119‐27. - PubMed
Korstjens 2008 {published data only}
    1. Korstjens I, May AM, Weert E, Mesters I, Tan F, Ros WJ, et al. Quality of life after self‐management cancer rehabilitation: a randomized controlled trial comparing physical and cognitive‐behavioral training versus physical training. Psychosomatic Medicine 2008;70(4):422‐9. - PubMed
Lauchlan 2011 {published data only}
    1. Lauchlan DT, McCaul JA, McCarron T, Patil S, McManners J, McGarva J. An exploratory trial of preventative rehabilitation on shoulder disability and quality of life in patients following neck dissection surgery. European Journal of Cancer Care 2011;20(1):113‐22. - PubMed
Lee 2009 {published data only}
    1. Lee WL, Liu WM, Cheng MH, Chao HT, Fuh JL, Wang PH. Uterine vascular occlusion in management of leiomyomas: laparoscopy vs laparotomy. Journal of Minimal Invasive Gynecology 2009;16(5):562‐8. - PubMed
Madore 2014 {published data only}
    1. Madore S, Kilbourn K, Valverde P, Borrayo E, Raich P. Feasibility of a psychosocial and patient navigation intervention to improve access to treatment among underserved breast cancer patients. Supportive Care in Cancer 2014;22(8):2085‐93. - PubMed
May 2009 {published data only}
    1. May A, Korstjens I, Weert E, Borne B, Hoekstra‐Weebers J, Schans CP, et al. Long‐term effects on cancer survivors' quality of life of physical training versus physical training combined with cognitive‐behavioral therapy: results from a randomized trial. Supportive Care in Cancer 2009;17(6):653‐63. - PubMed
McNeely 2008 {published data only}
    1. McNeely ML, Parliament MB, Seikaly H, Jha N, Magee DJ, Haykowsky MJ, et al. Effect of exercise on upper extremity pain and dysfunction in head and neck cancer survivors: a randomized controlled trial. Cancer 2008;113(1):214‐22. - PubMed
Meneses 2007 {published data only}
    1. Meneses KD, McNees P, Loerzel VW, Su X, Zhang Y, Hassey LA. Transition from treatment to survivorship: effects of a psychoeducational intervention on quality of life in breast cancer survivors. Oncology Nursing Forum 2007;34(5):1007‐16. - PubMed
Meraviglia 2013 {published data only}
    1. Meraviglia M, Stuifbergen A, Parsons D, Morgan S. Health promotion for cancer survivors: adaptation and implementation of an intervention. Holistic Nursing Practice 2013;27(3):140‐7. - PubMed
Mock 1994 {published data only}
    1. Mock V, Burke MB, Sheehan P, Creaton EM, Winningham ML, McKenney‐Tedder S, et al. A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncology Nursing Forum 1994;21(5):899‐907. - PubMed
Norager 2006 {published data only}
    1. Norager CB, Jensen MB, Madsen MR, Qvist N, Laurberg S. Effect of darbepoetin alfa on physical function in patients undergoing surgery for colorectal cancer. A randomized, double‐blind, placebo‐controlled study. Oncology 2006;71(3‐4):212‐20. - PubMed
Nowrouzi 2009 {published data only}
    1. Nowrouzi B, Lightfoot N, Cote K, Watson R. Workplace support for employees with cancer. Current Oncology 2009;16(5):15‐22. - PMC - PubMed
O'Brien 2014 {published data only}
    1. O'Brien L, Loughnan A, Purcell A, Haines T. Education for cancer‐related fatigue: could talking about it make people more likely to report it?. Supportive Care in Cancer 2014;22(1):209‐15. - PubMed
Persson 2010 {published data only}
    1. Persson P, Brynhildsen J, Kjølhede P, Hysterectomy Multicentre Study Group in South‐East Sweden. Short‐term recovery after subtotal and total abdominal hysterectomy‐‐a randomised clinical trial. BJOG 2010;117(4):469‐78. - PubMed
Poppelreuter 2009 {published data only}
    1. Poppelreuter M, Weis J, Bartsch HH. Effects of specific neuropsychological training programs for breast cancer patients after adjuvant chemotherapy. Journal of Psychosocial Oncology 2009;27(2):274‐96. - PubMed
Rotstein 1989 {published data only}
    1. Rotstein S, Nilsson B, Gustavson‐Kadaka E, Andersson S. Long‐term follow‐up of sickness periods in breast cancer patients primarily treated with surgery and radiotherapy or surgery only. Acta Oncologica 1989;28(6):817‐22. - PubMed
Salonen 2010 {published data only}
    1. Salonen P, Kellokumpu‐Lehtinen PL, Tarkka MT, Koivisto AM, Kaunonen M. Changes in quality of life in patients with breast cancer. Journal of Clinical Nursing 2011;20(1‐2):255‐66. - PubMed
Scott 2013 {published data only}
    1. Scott DA, Mills M, Black A, Cantwell M, Campbell A, Cardwell CR, et al. Multidimensional rehabilitation programmes for adult cancer survivors. Cochrane Database of Systematic Reviews 2013, Issue 3. [DOI: 10.1002/14651858.CD007730.pub2] - DOI - PMC - PubMed
Seibaek 2009 {published data only}
    1. Seibaek L, Petersen L. Nurse‐led rehabilitation after gynaecological cancer surgery: preliminary results from a clinically controlled, prospective questionnaire study. Supportive Care in Cancer 2009;17(5):601‐5. - PubMed
Seiler 2005 {published data only}
    1. Seiler CA, Wagner M, Bachmann T, Redaelli CA, Schmied B, Uhl W, et al. Randomized clinical trial of pylorus‐preserving duodenopancreatectomy versus classical Whipple resection ‐ long term results. British Journal of Surgery 2005;92(5):547‐56. - PubMed
Semple 2009 {published data only}
    1. Semple C, Dunwoody L, Kernohan W, McCaughan E. Development and evaluation of a problem‐focused psychosocial intervention for patients with head and neck cancer. Supportive Care in Cancer 2009;17(4):379‐88. - PubMed
Shelton 2009 {published data only}
    1. Shelton ML, Lee JQ, Morris GS, Massey PR, Kendall DG, Munsell MF, et al. A randomized control trial of a supervised versus a self‐directed exercise program for allogeneic stem cell transplant patients. Psycho‐Oncology 2009;18(4):353‐9. - PubMed
Sherer 1997 {published data only}
    1. Shere M, Meyers CA, Bergloff P. Efficacy of post‐acute brain injury rehabilitation for patients with primary malignant brain tumors. Cancer 1997;80(2):250‐7. - PubMed
Sherman 2010 {published data only}
    1. Sherman KA, Heard G, Cavanagh KL. Psychological effects and mediators of a group multi‐component program for breast cancer survivors. Journal of Behavioral Medicine 2010;33(5):378‐91. - PubMed
Sherman 2012 {published data only}
    1. Sherman DW, Haber J, Hoskins CN, Budin WC, Maislin G, Shukla S, et al. The effects of psychoeducation and telephone counseling on the adjustment of women with early‐stage breast cancer. Applied Nursing Research 2012;25(1):3‐16. - PubMed
Shimada 2007 {published data only}
    1. Shimada Y, Chida S, Matsunaga T, Sato M, Hatakeyama K, Itoi E. Clinical results of rehabilitation for accessory nerve palsy after radical neck dissection. Acta Otolaryngology 2007;127(5):491‐7. - PubMed
Silver 2013 {published data only}
    1. Silver JK, Baima J, Newman R, Galantino ML, Shockney LD. Cancer rehabilitation may improve function in survivors and decrease the economic burden of cancer to individuals and society. Work 2013;46(4):455‐72. - PubMed
Vos 2006 {published data only}
    1. Vos PJ, Visser AP, Garssen B, Duivenvoorden HJ, Haes HC. Effects of delayed psychosocial interventions versus early psychosocial interventions for women with early stage breast cancer. Patient Education and Counselling 2006;60(2):212‐9. - PubMed
Wenzel 1995 {published data only}
    1. Wenzel LB, Robinson SE, Blake DD. The effects of problem‐focused group counselling for earl‐stage gynecologic cancer patients. Journal of Mental Health Counselling 1995;17(1):81‐93.
Wiggins 2009 {published and unpublished data}
    1. Wiggins MS, Simonavice EM. Quality of life benefits in cancer survivorship with supervised exercise. Psychological Reports 2009;104(2):421‐4. - PubMed

References to ongoing studies

NCT01799031 {published data only}
    1. NCT01799031. Educational Intervention for Reducing Work Disability in Breast Cancer Survivors. https://clinicaltrials.gov/ct2/show/NCT01799031 (accessed 27 August 2015).
NTR2138 {published data only}
    1. NTR2138. Physical Activity during Cancer Treatment study. http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2138 (accessed 27 August 2015).

Additional references

American Cancer Society 2015
    1. American Cancer Society. Cancer facts & figures 2015. http://www.cancer.org/acs/groups/content/@editorial/documents/document/a... (accessed 27 August 2015).
Aziz 2007
    1. Aziz NM. Cancer survivorship research: state of knowledge, challenges and opportunities. Acta Oncologica 2007;46(4):417‐32. - PubMed
Beck 2003
    1. Beck LA. Cancer rehabilitation: does it make a difference?. Rehabilitation Nursing 2003;28(2):42‐7. - PubMed
Chinn 2000
    1. Chinn S. A simple method for converting an odds ratio to effect size for use in meta‐analysis. Statistics in Medicine 2000;19(22):3127‐31. - PubMed
Cooper 2013
    1. Cooper AF, Hankins M, Rixon L, Eaton E, Grunfeld EA. Distinct work‐related, clinical and psychological factors predict return to work following treatment in four different cancer types. Psychooncology 2013;22(3):659‐67. - PubMed
De Backer 2009
    1. Backer IC, Schep G, Backx FJ, Vreugdenhil G, Kuipers H. Resistance training in cancer survivors: a systematic review. International Journal of Sports Medicine 2009;30(10):703‐12. - PubMed
de Boer 2006
    1. Boer AG, Verbeek JH, Dijk FJ. Adult survivors of childhood cancer and unemployment: A metaanalysis. Cancer 2006;107(1):1‐11. - PubMed
de Boer 2008
    1. Boer AG, Verbeek JH, Spelten ER, Uitterhoeve AL, Ansink AC, Reijke TM, et al. Work ability and return‐to‐work in cancer patients. British Journal of Cancer 2008;98(8):1342‐7. - PMC - PubMed
de Boer 2009
    1. Boer AG, Taskila T, Ojajärvi A, Dijk FJ, Verbeek JH. Cancer survivors and unemployment: a meta‐analysis and meta‐regression. JAMA 2009;301(7):753‐62. - PubMed
de Boer 2014
    1. Boer AG. The European Cancer and Work Network: CANWON. Journal of Occupational Rehabilitation 2014;24(3):393‐8. - PubMed
Feuerstein 2007
    1. Feuerstein M, Hansen JA, Calvio LC, Johnson L, Ronquillo JG. Work productivity in brain tumor survivors. Journal of Occupational and Environmental Medicine 2007;49(7):803‐11. - PubMed
Franche 2005
    1. Franche RL, Cullen K, Clarke J, Irvin E, Sinclair S, Frank J. Workplace‐based return‐to‐work interventions: a systematic review of the quantitative literature. Journal of Occupational Rehabilitation 2005;15(4):607‐31. - PubMed
GRADEpro GDT 2015 [Computer program]
    1. McMaster University (developed by Evidence Prime, Inc.). GRADEpro GDT: GRADEpro Guideline Development Tool. Available from www.gradepro.org. McMaster University (developed by Evidence Prime, Inc.), 2015.
Haaf 2005
    1. Haaf HG. Findings on the effectiveness of rehabilitation [Ergebnisse zur Wirksamkeit der Rehabilitation]. Die Rehabilitation 2005;44(5):259‐76. - PubMed
Harvey 1982
    1. Harvey RF, Jellinek HM, Habeck RV. Cancer rehabilitation. An analysis of 36 program approaches. JAMA 1982;247(15):2127‐31. - PubMed
Hersch 2009
    1. Hersch J, Juraskova I, Price M, Mullan B. Psychosocial interventions and quality of life in gynaecological cancer patients: a systematic review. Psycho‐oncology 2009;18(8):795‐810. - PubMed
Higgins 2011
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.
Hoffman 2005
    1. Hoffman B. Cancer survivors at work: a generation of progress. CA: A Cancer Journal for Clinicians 2005;55(5):271‐80. - PubMed
Hoving 2009
    1. Hoving JL, Broekhuizen MLA, Frings‐Dresen MHW. Return to work of breast cancer survivors: a systematic review of intervention studies. BMC Cancer 2009;9:117. - PMC - PubMed
Irwin 2004
    1. Irwin ML, Ainsworth BE. Physical activity interventions following cancer diagnosis: methodologic challenges to delivery and assessment. Cancer Investigation 2004;22(1):30‐50. - PubMed
Kennedy 2007
    1. Kennedy F, Haslam C, Munir F, Pryce J. Returning to work following cancer: a qualitative exploratory study into the experience of returning to work following cancer. European Journal of Cancer Care 2007;16(1):17‐25. - PubMed
Khan 2009
    1. Khan F, Ng L, Turner‐Stokes L. Effectiveness of vocational rehabilitation intervention on the return to work and employment of persons with multiple sclerosis. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD007256.pub2] - DOI - PMC - PubMed
Kirshbaum 2007
    1. Kirshbaum MN. A review of the benefits of whole body exercise during and after treatment for breast cancer. Journal of Clinical Nursing 2007;16(1):104‐21. - PubMed
Kirshblum 2001
    1. Kirshblum S, O'Dell MW, Ho C, Barr K. Rehabilitation of persons with central nervous system tumors. Cancer 2001;92(4 Suppl):1029‐38. - PubMed
Liu 2009
    1. Liu RD, Chinapaw MJ, Huijgens PC, Mechelen W. Physical exercise interventions in haematological cancer patients, feasible to conduct but effectiveness to be established: a systematic literature review. Cancer Treatment Reviews 2009;35(2):185‐92. - PubMed
Macmillan 2013
    1. Macmillan Cancer Support. Making the Shift – Providing specialist work support to people with cancer. http://www.macmillan.org.uk/Documents/GetInvolved/Campaigns/WorkingThrou... (accessed 27 August 2015).
Marmot 2012
    1. Marmot M, Allen J, Bell R, Bloomer E, Goldblatt P, Consortium for the European Review of Social Determinants of Health and the Health Divide. WHO European review of social determinants of health and the health divide. Lancet 2012;380(9846):1011‐29. - PubMed
McNeely 2006
    1. McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS. Effects of exercise on breast cancer patients and survivors: a systematic review and meta‐analysis. Canadian Medical Association Journal 2006;175(1):34‐41. - PMC - PubMed
Mehnert 2011
    1. Mehnert A. Employment and work‐related issues in cancer survivors. Critical Reviews in Oncology/Hematology 2011;77(2):109‐30. - PubMed
Mehnert 2013
    1. Mehnert A, Boer A, Feuerstein M. Employment challenges for cancer survivors. Cancer 2013;119(Suppl 11):2151‐9. - PubMed
Moskowitz 2014
    1. Moskowitz MC, Todd BL, Chen R, Feuerstein M. Function and friction at work: a multidimensional analysis of work outcomes in cancer survivors. Journal of Cancer Survivorship: Research and Practice 2014;8(2):173‐82. - PubMed
Nieuwenhuijsen 2014
    1. Nieuwenhuijsen K, Faber B, Verbeek JH, Neumeyer‐Gromen A, Hees HL, Verhoeven AC, et al. Interventions to improve return to work in depressed people. Cochrane Database of Systematic Reviews 2014, Issue 12. [DOI: 10.1002/14651858.CD006237.pub3] - DOI - PMC - PubMed
Norlund 2009
    1. Norlund A, Ropponen A, Alexanderson K. Multidisciplinary interventions: review of studies of return to work after rehabilitation for low back pain. Journal of Rehabilitation Medicine 2009;41(3):115‐21. - PubMed
Oldervoll 2004
    1. Oldervoll LM, Kaasa S, Hjermstad MJ, Lund JA, Loge JH. Physical exercise results in the improved subjective well‐being of a few or is effective rehabilitation for all cancer patients?. European Journal of Cancer 2004;40(7):951‐62. - PubMed
Osborn 2006
    1. Osborn RL, Demoncada AC, Feuerstein M. Psychosocial interventions for depression, anxiety, and quality of life in cancer survivors: meta‐analyses. International Journal of Psychiatry in Medicine 2006;36(1):13‐34. - PubMed
RevMan 2014 [Computer program]
    1. The Nordic Cochrane Centre. The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre. The Cochrane Collaboration, 2014.
Robinson 2002
    1. Robinson KA, Dickersin K. Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. International Journal of Epidemiology 2002;31(1):150‐3. - PubMed
Short 2005
    1. Short P, Vasey JJ, Tuncelli K. Employment pathways in a large cohort of adult cancer survivors. Cancer 2005;103(6):1292‐301. - PubMed
Smith 2007
    1. Smith T, Stein KD, Mehta CC, Kaw C, Kepner JL, Buskirk T, et al. The rationale, design, and implementation of the American Cancer Society's studies of cancer survivors. Cancer 2007;109(1):1‐12. - PubMed
Spelten 2002
    1. Spelten ER, Sprangers MA, Verbeek JH. Factors reported to influence the return to work of cancer survivors: a literature review. Psycho‐oncology 2002;11(2):124‐31. - PubMed
Stanton 2006
    1. Stanton AL. Psychosocial concerns and interventions for cancer survivors. Journal of Clinical Oncology 2006;24(32):5132‐7. - PubMed
Steiner 2010
    1. Steiner JF, Nowels CT, Main DS. Returning to work after cancer: quantitative studies and prototypical narratives. Psycho‐oncology 2010;19(2):115‐24. - PMC - PubMed
Strauser 2010
    1. Strauser D, Feuerstein M, Chan F, Arango J, Silva Cardoso E, Chiu CY. Vocational services associated with competitive employment in 18‐25 year old cancer survivors. Journal of Cancer Survivorship: Research and Practice 2010;4(2):179‐86. - PubMed
Taskila 2007a
    1. Taskila T, Lindbohm ML. Factors affecting cancer survivors' employment and work ability. Acta Oncologica 2007;46(4):446‐51. - PubMed
Taskila 2007b
    1. Taskila T, Martikainen R, Hietanen P, Lindbohm ML. Comparative study of work ability between cancer survivors and their referents. European Journal of Cancer 2007;43(5):914‐20. - PubMed
van der Molen 2009
    1. Molen LA, Rossum MAA, Burkhead LM, Smeele LE, Hilgers FJ. Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. European Archives of Oto‐rhino‐laryngology 2009;266(6):889‐900. - PubMed
Verbeek 2007
    1. Verbeek J, Spelten E. Work. In: Feuerstein M editor(s). Handbook of Cancer Survivorship. Berkeley: Springer, 2007.
Verdecchia 2009
    1. Verdecchia A, Guzzinati S, Francisci S, Angelis R, Bray F, Allemani C, et al. Survival trends in European cancer patients diagnosed from 1988 to 1999. European Journal of Cancer 2009;45(6):1042‐66. - PubMed
Zhang 1998
    1. Zhang J, Yu KF. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 1998;280(19):1690‐1. - PubMed

References to other published versions of this review

De Boer 2011
    1. Boer AG, Taskila T, Tamminga SJ, Frings‐Dresen MH, Feuerstein M, Verbeek JH. Interventions to enhance return‐to‐work for cancer patients. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD007569.pub2] - DOI - PubMed

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