Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review
- PMID: 22045287
- DOI: 10.1097/NRL.0b013e31822b54d2
Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review
Abstract
Introduction: Trihexyphenidyl is 1 of the most effective agents for treatment of young-onset dystonia. As such, women of childbearing potential use trihexyphenidyl despite inadequate information about potential effects on pregnancy, labor, and fetal development.
Case report: We report 2 uncomplicated pregnancies in 1 woman with early-onset, sporadic, primary generalized dystonia (DYT1 negative) treated with high dosage trihexyphenidyl and review the literature on antidystonic agents and pregnancy.
Conclusion: Although there is limited data, our case demonstrates that high-dosage trihexyphenidyl treatment is not necessarily a contraindication to pregnancy.
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