Functional brown adipose tissue in healthy adults
- PMID: 19357407
- DOI: 10.1056/NEJMoa0808949
Functional brown adipose tissue in healthy adults
Erratum in
- N Engl J Med. 2009 Sep 10;361(11):1123
Abstract
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
2009 Massachusetts Medical Society
Comment in
-
Brown adipose tissue--when it pays to be inefficient.N Engl J Med. 2009 Apr 9;360(15):1553-6. doi: 10.1056/NEJMe0900466. N Engl J Med. 2009. PMID: 19357412 Free PMC article. No abstract available.
-
The importance of brown adipose tissue.N Engl J Med. 2009 Jul 23;361(4):415-6; author reply 418-21. doi: 10.1056/NEJMc091009. N Engl J Med. 2009. PMID: 19625723 No abstract available.
-
The importance of brown adipose tissue.N Engl J Med. 2009 Jul 23;361(4):416-7; author reply 418-21. N Engl J Med. 2009. PMID: 19630141 No abstract available.
-
The importance of brown adipose tissue.N Engl J Med. 2009 Jul 23;361(4):417; author reply 418-21. N Engl J Med. 2009. PMID: 19630143 No abstract available.
Similar articles
-
Brown adipose tissue: what have we learned since its recent identification in human adults.Arq Bras Endocrinol Metabol. 2014 Dec;58(9):889-99. doi: 10.1590/0004-2730000003492. Arq Bras Endocrinol Metabol. 2014. PMID: 25627043 Review.
-
Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans.Int J Obes (Lond). 2013 Jul;37(7):993-8. doi: 10.1038/ijo.2012.161. Epub 2012 Oct 2. Int J Obes (Lond). 2013. PMID: 23032405
-
Identification and importance of brown adipose tissue in adult humans.N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780. N Engl J Med. 2009. PMID: 19357406 Free PMC article.
-
Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region.J Clin Endocrinol Metab. 2013 Jul;98(7):E1230-4. doi: 10.1210/jc.2013-1348. Epub 2013 Jun 19. J Clin Endocrinol Metab. 2013. PMID: 23783102
-
[Human brown adipose tissue].Duodecim. 2015;131(22):2075-82. Duodecim. 2015. PMID: 26749900 Review. Finnish.
Cited by
-
Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis.Cell Metab. 2013 Jul 2;18(1):118-29. doi: 10.1016/j.cmet.2013.06.003. Cell Metab. 2013. PMID: 23823482 Free PMC article.
-
MRI characterization of brown adipose tissue in obese and normal-weight children.Pediatr Radiol. 2015 Oct;45(11):1682-9. doi: 10.1007/s00247-015-3391-z. Epub 2015 Jun 20. Pediatr Radiol. 2015. PMID: 26092667
-
Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.Obesity (Silver Spring). 2013 Sep;21(9):E415-20. doi: 10.1002/oby.20338. Obesity (Silver Spring). 2013. PMID: 23408649 Free PMC article.
-
Adipose Tissue Development and Expansion from the Womb to Adolescence: An Overview.Nutrients. 2020 Sep 8;12(9):2735. doi: 10.3390/nu12092735. Nutrients. 2020. PMID: 32911676 Free PMC article. Review.
-
Bariatric surgery and type 2 diabetes: are there weight loss-independent therapeutic effects of upper gastrointestinal bypass?J Intern Med. 2016 Nov;280(5):476-486. doi: 10.1111/joim.12527. Epub 2016 Oct 14. J Intern Med. 2016. PMID: 27739136 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials