doi: 10.1016/j.bmcl.2005.08.086.
Epub 2005 Sep 23.
Angiogenesis inhibitors derived from thalidomide
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- PMID: 16183272
- DOI: 10.1016/j.bmcl.2005.08.086
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Angiogenesis inhibitors derived from thalidomide
Bioorg Med Chem Lett.
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Abstract
5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33: 10), which was obtained during our previous structural development studies on thalidomide, was revealed to possess potent anti-angiogenic activity in a human umbilical vein endothelial cell (HUVEC) assay. Thalidomide (1) and its metabolite, 5-hydroxythalidomide (5-HT: 2), which possesses a hydroxyl group at the position corresponding to that of 5HPP-33, as well as IMiDs (immunomodulatory derivatives of thalidomide: 3 and 5), also showed weak or moderate activity in the same assay.
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