A structured review of studies on health-related quality of life and economic evaluation in pediatric acute lymphoblastic leukemia
- PMID: 15504922
- DOI: 10.1093/jncimonographs/lgh002
A structured review of studies on health-related quality of life and economic evaluation in pediatric acute lymphoblastic leukemia
Abstract
Background: A comprehensive review was made of the literature on the health-related quality of life (HRQL) and economic outcomes of children with acute lymphoblastic leukemia (ALL), the most common of all cancers in childhood.
Objectives: The primary objectives of the review were to locate and describe measures of HRQL used in pediatrics and in pediatric oncology that might be applicable to ALL, to summarize studies that have applied HRQL measures to ALL, to identify and summarize economic evaluations of the costs and consequences of care for pediatric ALL, and to identify areas requiring further research.
Data sources: To identify the HRQL literature in pediatric ALL, searches were run on the major biomedical and social science bibliographic databases. Search terms included a variety of MeSH and other thesaurus terms, text words, names of HRQL instruments, and the names of key authors in the field. The economic literature searches included most of the same databases, with the addition of the National Health Service Economic Evaluation Database and EconLit. Searches on specific authors and instruments and hand searches were also conducted.
Study selection: Only English language studies published from 1975 through 2000 were included.
Data extraction: Standardized data extraction forms were used to abstract information from HRQL and economic evaluation studies. Two reviewers independently screened the search results, and differences were resolved by consensus.
Data synthesis: A number of generic HRQL measures, both adult and pediatric, have been applied in pediatric ALL. In addition, a number of pediatric oncology-specific instruments and pediatric oncology disease-specific instruments have been developed. Most of these instruments have been used to measure the health status of patients undergoing therapy. Despite the limited numbers of patients and resources available to assess HRQL measures in children with cancer, a fairly substantial body of literature has been published. Economic studies of pediatric ALL have only recently been undertaken. Most studies focus on a particular, narrow aspect of costs associated with the disease. There are relatively few cost-effectiveness studies that compare the costs and consequences of two or more treatment options. There are no published, comprehensive economic evaluations of pediatric ALL.
Conclusions: HRQL measures provide not only important information on the improvements offered by new therapies but also an outcome measure for economic evaluations. Recently developed HRQL measures and applications that include the direct assessments of children are important contributions. By the age of 7 or 8 years, children can generally provide reliable responses. Furthermore, children often provide information that is not available from parental reports (e.g., in the more subjective areas of pain and emotion). However, the use of multiple viewpoints, such as the patient, parent, and health professional perspectives, can provide valid and important complementary information. Expertise in HRQL measurement should be included in the design of most future trials. Funds for HRQL research should be made available to enhance the scope of HRQL activities by organizations such as the Children's Oncology Group. In the near future, further work to generate evidence of validity for available HRQL measures for use in children with ALL will be a high priority. Continuation of inquiries into the methods for HRQL assessment of younger children (i.e., preschoolers) is also a priority.
Comment in
-
Re: A structured review of studies on health-related quality of life and economic evaluation in pediatric acute lymphoblastic leukemia.J Natl Cancer Inst. 2005 Dec 7;97(23):1786; author reply 1786-7. doi: 10.1093/jnci/dji405. J Natl Cancer Inst. 2005. PMID: 16333035 No abstract available.
Similar articles
-
Quality-adjusted life-years lack quality in pediatric care: a critical review of published cost-utility studies in child health.Pediatrics. 2005 May;115(5):e600-14. doi: 10.1542/peds.2004-2127. Pediatrics. 2005. PMID: 15867026 Review.
-
Health-related quality of life in children and adolescents who have a diagnosis of attention-deficit/hyperactivity disorder.Pediatrics. 2004 Nov;114(5):e541-7. doi: 10.1542/peds.2004-0844. Pediatrics. 2004. PMID: 15520087
-
Implementing and using quality measures for children's health care: perspectives on the state of the practice.Pediatrics. 2004 Jan;113(1 Pt 2):217-27. Pediatrics. 2004. PMID: 14702504
-
Health-related quality of life, satisfaction, and economic outcome measures in studies of prostate cancer screening and treatment, 1990-2000.J Natl Cancer Inst Monogr. 2004;(33):78-101. doi: 10.1093/jncimonographs/lgh016. J Natl Cancer Inst Monogr. 2004. PMID: 15504921 Review.
-
Procedures and methods of benefit assessments for medicines in Germany.Eur J Health Econ. 2008 Nov;9 Suppl 1:5-29. doi: 10.1007/s10198-008-0122-5. Eur J Health Econ. 2008. PMID: 18987905
Cited by
-
Congruence of reproductive concerns among adolescents with cancer and parents: pilot testing an adapted instrument.Pediatrics. 2012 Apr;129(4):e930-6. doi: 10.1542/peds.2011-2568. Epub 2012 Mar 19. Pediatrics. 2012. PMID: 22430446 Free PMC article.
-
Global Mapping of Interventions to Improve Quality of Life of Patients with Cancer: A Protocol for Literature Mining and Meta-Analysis.Int J Environ Res Public Health. 2022 Dec 2;19(23):16155. doi: 10.3390/ijerph192316155. Int J Environ Res Public Health. 2022. PMID: 36498229 Free PMC article.
-
Health-related quality of life among children with cancer in Hyderabad, India.Indian J Pediatr. 2009 Dec;76(12):1231-5. doi: 10.1007/s12098-009-0262-3. Indian J Pediatr. 2009. PMID: 19936653
-
Longitudinal analysis of quality-of-life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial.Cancer. 2018 Feb 1;124(3):571-579. doi: 10.1002/cncr.31085. Epub 2017 Nov 7. Cancer. 2018. PMID: 29112230 Free PMC article.
-
Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331.Int J Cancer. 2016 Jan 15;138(2):332-9. doi: 10.1002/ijc.29708. Epub 2015 Sep 3. Int J Cancer. 2016. PMID: 26235006 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources