Review
doi: 10.1016/j.bbamcr.2003.08.008.
Roc, a Ras/GTPase domain in complex proteins
Affiliations
- PMID: 14654223
- DOI: 10.1016/j.bbamcr.2003.08.008
Item in Clipboard
Review
Roc, a Ras/GTPase domain in complex proteins
Biochim Biophys Acta.
.
Free article
Abstract
We identified a novel group of the Ras/GTPase superfamily, termed Roc, that is present as domain in complex proteins together with other domains, including leucine-rich repeats (LRRs), ankyrin repeats, WD40 repeats, kinase domains, RasGEF and RhoGAP domains. Roc is always succeeded by a novel 300-400-amino-acid-long domain, termed COR. Proteins with Roc/COR are present in prokaryotes, Dictyostelium, plants and metazoa.
Similar articles
-
The Parkinson disease gene LRRK2: evolutionary and structural insights.Mol Biol Evol. 2006 Dec;23(12):2423-33. doi: 10.1093/molbev/msl114. Epub 2006 Sep 11. Mol Biol Evol. 2006. PMID: 16966681
-
Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.J Biol Chem. 2008 Oct 31;283(44):30412-20. doi: 10.1074/jbc.M804265200. Epub 2008 Aug 14. J Biol Chem. 2008. PMID: 18703517 Free PMC article.
-
Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.Biosci Rep. 2015 Aug 26;35(5):e00254. doi: 10.1042/BSR20150128. Biosci Rep. 2015. PMID: 26310572 Free PMC article.
-
Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.Biochem Soc Trans. 2012 Oct;40(5):1086-9. doi: 10.1042/BST20120088. Biochem Soc Trans. 2012. PMID: 22988870 Review.
-
The Roco protein family: a functional perspective.FASEB J. 2008 Sep;22(9):3103-10. doi: 10.1096/fj.08-111310. Epub 2008 Jun 3. FASEB J. 2008. PMID: 18523161 Review.
Cited by
-
A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.Mol Cell Proteomics. 2011 Jan;10(1):M110.001172. doi: 10.1074/mcp.M110.001172. Epub 2010 Sep 27. Mol Cell Proteomics. 2011. PMID: 20876399 Free PMC article.
-
LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson's disease patients.J Neural Transm (Vienna). 2010 Jul;117(7):847-53. doi: 10.1007/s00702-010-0423-6. Epub 2010 Jun 11. J Neural Transm (Vienna). 2010. PMID: 20544233
-
Roc, the G-domain of the Parkinson's disease-associated protein LRRK2.Trends Biochem Sci. 2022 Dec;47(12):1038-1047. doi: 10.1016/j.tibs.2022.06.009. Epub 2022 Jul 12. Trends Biochem Sci. 2022. PMID: 35840518 Free PMC article. Review.
-
The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System.Front Neurosci. 2020 Mar 18;14:227. doi: 10.3389/fnins.2020.00227. eCollection 2020. Front Neurosci. 2020. PMID: 32256311 Free PMC article. Review.
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.ASN Neuro. 2009 Apr 14;1(1):e00002. doi: 10.1042/AN20090007. ASN Neuro. 2009. PMID: 19570025 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
