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. 2002 Oct;141(4):572-5.
doi: 10.1067/mpd.2002.127503.

Cutaneous manifestations of hyper-IgE syndrome in infants and children

Sarah L Chamlin  1 , Timothy H McCalmont, Bari B Cunningham, Nancy B Esterly, Chan-Ho Lai, Susan Bayliss Mallory, Anthony J Mancini, Joan Tamburro, Ilona J Frieden
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Cutaneous manifestations of hyper-IgE syndrome in infants and children

Sarah L Chamlin et al. J Pediatr. 2002 Oct.

Abstract

We describe 8 children with hyper-IgE syndrome who had papulopustular eruption on the face and scalp in the first year of life. Seven of the 8 patients had persistent peripheral eosinophilia and 3 had leukocytosis noted before diagnosis. Skin biopsy specimens in 6 patients revealed spongiosis and perivascular dermatitis and/or folliculitis with a predominance of eosinophils. Two patients had bone fractures and osteopenia. Recurrent pneumonia occurred in 6 children and pneumatoceles in 5. The diagnosis of hyper-IgE syndrome was made an average of 18 months after the onset of the initial papulopustular eruption. These findings may lead to earlier recognition of the disease and institution of appropriate treatment.

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