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. 2002 Jan;79(1):87-94.
doi: 10.1006/geno.2001.6684.

WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35

G Mark Xu  1 , M Amin Arnaout
Affiliations

WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35

G Mark Xu et al. Genomics. 2002 Jan.

Abstract

WW domains mediate protein-protein interactions in many intracellular processes. In pre-mRNA splicing, WW domains participate in cross-intron bridging. These WW domains are characterized by a central aromatic block of three tyrosine residues. We identified a novel protein containing the same type of WW domain. The gene encoding the protein, named WAC, is located in human chromosome 10p11.2-10p12.1. A Drosophila melanogaster WAC homolog (CG8949) was identified as a Rosetta stone protein. Domain fusion analysis of the Rosetta stone protein linked WAC to splicing factor SNRP70. WAC existed mainly in a tyrosine-phosphorylated form. Immunofluorescence analysis colocalized WAC with SC35, the marker for pre-mRNA splicing machinery. Our analysis suggests that WAC represents a novel member of WW-domain-containing proteins for RNA processing.

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