Alternative titles; symbols
Cytogenetic location: 15q11-q13 Genomic coordinates (GRCh38) : 15:19,000,001-33,400,000
Jong et al. (1999) characterized 2 genes, termed ZNF127 (MKRN3; 603856) and ZNF127AS, which are encoded in the complex imprinted locus on 15q11-q13. The presence of various zinc finger motifs in the ZNF127 polypeptide predicts that it functions as a ribonucleoprotein. The intronless ZNF127 gene is expressed ubiquitously; however, the entire coding sequence and 5-prime CpG island overlap a second gene, ZNF127AS, which is transcribed from the antisense strand with a different transcript size and pattern of expression. Northern blot analysis revealed that the ZNF127AS gene is expressed as approximately 7- and 11-kb transcripts predominantly in brain and lung. Jong et al. (1999) concluded that ZNF127 and ZNF127AS are novel imprinted genes that may be associated with some of the clinical features of the polygenic Prader-Willi syndrome (176270).
Jong et al. (1999) mapped the MKRN3AS genen to chromosome 15q11-q13, where it overlaps the MKRN3 gene in the opposite orientation.
Jong, M. T. C., Gray, T. A., Ji, Y., Glenn, C. C., Saitoh, S., Driscoll, D. J., Nicholls, R. D. A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region. Hum. Molec. Genet. 8: 783-793, 1999. [PubMed: 10196367] [Full Text: https://doi.org/10.1093/hmg/8.5.783]