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Items: 1 to 20 of 4417

1.
Identification and validation of a T cell receptor targeting KRAS G12V in HLA-A*11:01 pancreatic cancer patients
Xiongfei Xu, Shiwei Guo, Haihui Gu, Zhanshan Cha, Xiaohan Shi, Xiaoyi Yin, Huan Wang, Suizhi Gao, Bo Li, Lingyu Zhu, Wei Jing, Kailian Zheng, Zhuo Shao, Peng Cheng, Chunhong Zheng, Yi-Ping Shih, Yunguang Li, Baohua Qian, Dong Gao, Eric Tran, Gang Jin
JCI Insight. 2025 Jan 23; 10(2): e181873. Published online 2025 Jan 23. doi: 10.1172/jci.insight.181873
PMCID:
PMC11790028
ArticlePDF–2.4M
2.
CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis
Junya Miyahara, Yasunori Omata, Ryota Chijimatsu, Hiroyuki Okada, Hisatoshi Ishikura, Junya Higuchi, Naohiro Tachibana, Kosei Nagata, Shoichiro Tani, Kenichi Kono, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi, Yasuhide Iwanaga, Asuka Terashima, Fumiko Yano, Masahide Seki, Yutaka Suzuki, Roland Baron, Sakae Tanaka, Taku Saito
JCI Insight. 2025 Jan 23; 10(2): e183690. Published online 2025 Jan 23. doi: 10.1172/jci.insight.183690
PMCID:
PMC11790023
ArticlePDF–19M
3.
Multidimensional, integrative profiling identifies BCL2L1 methylation as a predictor of MCL1 dependency in pediatric malignancies
Shazia Adjumain, Paul Daniel, Claire Xin Sun, Gabrielle Bradshaw, Nicole J. Chew, Vanessa Tsui, Hanbyeol Lee, Melissa Loi, Nataliya Zhukova, Dilru Habarakada, Abigail Yoel, Vijesh G. Vaghjiani, Shaye Game, Louise E. Ludlow, Naama Neeman, E. Alejandro Sweet-Cordero, David D. Eisenstat, Jason E. Cain, Ron Firestein
JCI Insight. 2025 Jan 23; 10(2): e184601. Published online 2025 Jan 23. doi: 10.1172/jci.insight.184601
PMCID:
PMC11790018
ArticlePDF–1.8M
4.
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury
Dan Su, Tadkamol Krongbaramee, Samuel Swearson, Yan Sweat, Mason Sweat, Fan Shao, Steven Eliason, Brad A. Amendt
JCI Insight. 2025 Jan 9; 10(1): e179815. Published online 2025 Jan 9. doi: 10.1172/jci.insight.179815
PMCID:
PMC11721312
ArticlePDF–10M
5.
Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness
Kayla R. Williams, Hoyt A.T.K. Bright, Allison D. Fryer, David B. Jacoby, Zhenying Nie
JCI Insight. 2025 Jan 9; 10(1): e181070. Published online 2025 Jan 9. doi: 10.1172/jci.insight.181070
PMCID:
PMC11721309
ArticlePDF–5.2M
6.
Casz1 and Znf101/Zfp961 differentially regulate apolipoproteins A1 and B, alter plasma lipoproteins, and reduce atherosclerosis
Abulaish Ansari, Pradeep Kumar Yadav, Liye Zhou, Binu Prakash, Laraib Ijaz, Amanda Christiano, Sameer Ahmad, Antoine Rimbert, M. Mahmood Hussain
JCI Insight. 2025 Jan 9; 10(1): e182260. Published online 2025 Jan 9. doi: 10.1172/jci.insight.182260
PMCID:
PMC11721306
ArticlePDF–2.0M
7.
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury
Hak Joo Lee, Yuyang Sun, Falguni Das, Wenjun Ju, Viji Nair, Christopher G. Kevil, Shankara Varadarajan, Guanshi Zhang, Goutam Ghosh Choudhury, Brij B. Singh, Matthias Kretzler, Robert G. Nelson, Kumar Sharma, Balakuntalam S. Kasinath
JCI Insight. 2025 Jan 9; 10(1): e174848. Published online 2025 Jan 9. doi: 10.1172/jci.insight.174848
PMCID:
PMC11721299
ArticlePDF–2.8M
8.
High-resolution multimodal profiling of human epileptic brain activity via explanted depth electrodes
Anuj Kumar Dwivedi, Arun Mahesh, Albert Sanfeliu, Julian Larkin, Rebecca A. Siwicki, Kieron J. Sweeney, Donncha F. O’Brien, Peter Widdess-Walsh, Simone Picelli, David C. Henshall, Vijay K. Tiwari
JCI Insight. 2025 Jan 9; 10(1): e184518. Published online 2025 Jan 9. doi: 10.1172/jci.insight.184518
PMCID:
PMC11721296
ArticlePDF–3.1M
9.
Myeloid DRP1 deficiency limits revascularization in ischemic muscles via inflammatory macrophage polarization and metabolic reprogramming
Shikha Yadav, Vijay C. Ganta, Sudhahar Varadarajan, Vy Ong, Yang Shi, Archita Das, Dipankar Ash, Sheela Nagarkoti, Malgorzata McMenamin, Stephanie Kelley, Tohru Fukai, Masuko Ushio-Fukai
JCI Insight. 2025 Jan 9; 10(1): e177334. Published online 2025 Jan 9. doi: 10.1172/jci.insight.177334
PMCID:
PMC11721294
ArticlePDF–3.8M
10.
Targeting hyaluronan synthesis enhances the therapeutic effectiveness of biologics in inflammatory bowel disease
Peng Xiao, Zhehang Chen, Xuechun Cai, Wenhao Xia, Xia Liu, Zhangfa Song, Huijuan Wang, Yuening Zhao, Youling Huang, Yu Zhang, Ke Guo, Haotian Chen, Rongbei Liu, Changcheng Meng, Yanfei Fang, Yunkun Lu, Qian Cao
JCI Insight. 2025 Jan 9; 10(1): e180425. Published online 2025 Jan 9. doi: 10.1172/jci.insight.180425
PMCID:
PMC11721290
ArticlePDF–9.3M
11.
Reprogramming of epidermal keratinocytes by PITX1 transforms the cutaneous cellular landscape and promotes wound healing
Andrew M. Overmiller, Akihiko Uchiyama, Emma D Hope, Subhashree Nayak, Christopher G. O’Neill, Kowser Hasneen, Yi-Wen Chen, Faiza Naz, Stefania Dell’Orso, Stephen R. Brooks, Kan Jiang, Maria I. Morasso
JCI Insight. 2024 Dec 20; 9(24): e182844. Published online 2024 Dec 20. doi: 10.1172/jci.insight.182844
PMCID:
PMC11665584
ArticlePDF–21M
12.
The IL-2 SYNTHORIN molecule promotes functionally adapted Tregs in a preclinical model of type 1 diabetes
Fernando Alvarez, Nicole V. Acuff, Glenn M. La Muraglia, II, Nazila Sabri, Marcos E. Milla, Jill M. Mooney, Matthew F. Mackey, Mark Peakman, Ciriaco A. Piccirillo
JCI Insight. 2024 Dec 20; 9(24): e182064. Published online 2024 Dec 20. doi: 10.1172/jci.insight.182064
PMCID:
PMC11665582
ArticlePDF–4.0M
13.
RTN1A mediates diabetes-induced AKI-to-CKD transition
Lulin Min, Ya Chen, Yixin Chen, Fang Zhong, Zhaohui Ni, Leyi Gu, Kyung Lee, John Cijiang He
JCI Insight. 2024 Dec 20; 9(24): e185826. Published online 2024 Dec 20. doi: 10.1172/jci.insight.185826
PMCID:
PMC11665580
ArticlePDF–4.6M
14.
Flotillin-2 dampens T cell antigen sensitivity and functionality
Sookjin Moon, Fei Zhao, Mohammad N. Uddin, Charles J. Tucker, Peer W.F. Karmaus, Michael B. Fessler
JCI Insight. 2024 Dec 20; 9(24): e182328. Published online 2024 Dec 20. doi: 10.1172/jci.insight.182328
PMCID:
PMC11665568
ArticlePDF–5.7M
15.
Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes
Ele Ferrannini, Simona Baldi, Maria Tiziana Scozzaro, Giulia Ferrannini, Michael K. Hansen
JCI Insight. 2024 Dec 20; 9(24): e180637. Published online 2024 Dec 20. doi: 10.1172/jci.insight.180637
PMCID:
PMC11665565
ArticlePDF–1.7M
16.
Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathway
Dong Won Kim, Soohyun Kim, Jeong Han, Karan Belday, Emily Li, Nicholas Mahoney, Seth Blackshaw, Fatemeh Rajaii
JCI Insight. 2024 Dec 20; 9(24): e182352. Published online 2024 Dec 20. doi: 10.1172/jci.insight.182352
PMCID:
PMC11665563
ArticlePDF–8.0M
17.
Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung
Emily M. King, Yifan Zhao, Camille M. Moore, Benjamin Steinhart, Kelsey C. Anderson, Brian Vestal, Peter K. Moore, Shannon A. McManus, Christopher M. Evans, Kara J. Mould, Elizabeth F. Redente, Alexandra L. McCubbrey, William J. Janssen
JCI Insight. 2024 Dec 20; 9(24): e182700. Published online 2024 Dec 20. doi: 10.1172/jci.insight.182700
PMCID:
PMC11665561
ArticlePDF–6.1M
18.
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia
Christopher A.G. Booth, Juliette M. Bouyssou, Katsuhiro Togami, Olivier Armand, Hembly G. Rivas, Kezhi Yan, Siobhan Rice, Shuyuan Cheng, Emily M. Lachtara, Jean-Pierre Bourquin, Alex Kentsis, Esther Rheinbay, James A. DeCaprio, Andrew A. Lane
JCI Insight. 2024 Dec 20; 9(24): e183889. Published online 2024 Dec 20. doi: 10.1172/jci.insight.183889
PMCID:
PMC11665559
ArticlePDF–2.3M
19.
A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder
Monica L. Faulkner, Mehdi Farokhnia, Mary R. Lee, Lisa Farinelli, Brittney D. Browning, Kelly Abshire, Allison M. Daurio, Vikas Munjal, Sara L. Deschaine, Selim R. Boukabara, Christopher Fortney, Garrick Sherman, Melanie Schwandt, Fatemeh Akhlaghi, Reza Momenan, Thomas J. Ross, Susan Persky, Lorenzo Leggio
JCI Insight. 2024 Dec 20; 9(24): e182331. Published online 2024 Dec 20. doi: 10.1172/jci.insight.182331
PMCID:
PMC11665556
ArticlePDF–871K
20.
Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2
Sydney I. Ramirez, Paul G. Lopez, Farhoud Faraji, Urvi M. Parikh, Amy Heaps, Justin Ritz, Carlee Moser, Joseph J. Eron, David Wohl, Judith Currier, Eric S. Daar, Alex Greninger, Paul Klekotka, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Bjoern Peters, Michael D. Hughes, Kara W. Chew, Davey M. Smith, Shane Crotty, for the Accelerating COVID-19 Therapeutic Interventions and Vaccines-2 (ACTIV-2)/A5401 Study Team
JCI Insight. 2024 Dec 20; 9(24): e186078. Published online 2024 Dec 20. doi: 10.1172/jci.insight.186078
PMCID:
PMC11665554
ArticlePDF–3.1M

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