Prostate cancer, hereditary, X-linked 3(HPCX3)

MedGen UID:: 1861605
•Concept ID:: C5935569
•: Neoplastic Process

Synonyms:	HPCX3; PROSTATE CANCER, HEREDITARY, X-LINKED 3

Gene (location): Gene(s) directly associated with this condition or phenotype.	AR (Xq12)

Monarch Initiative:	MONDO:0971170
OMIM®:	301120

Definition

Genetic predisposition to prostate cancer has been well established. The androgen receptor gene became a compelling candidate for the study of prostate cancer because of the essential role that androgens play in prostate development, growth, and maintenance (Chang et al., 2002). For a general discussion of hereditary prostate cancer, see 176807. [from OMIM]

Recent clinical studies

Etiology

Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study.

Eng KH, Szender JB, Etter JL, Kaur J, Poblete S, Huang RY, Zhu Q, Grzesik KA, Battaglia S, Cannioto R, Krolewski JJ, Zsiros E, Frederick PJ, Lele SB, Moysich KB, Odunsi KO
PLoS Genet 2018 Feb;14(2):e1007194. Epub 2018 Feb 15 doi: 10.1371/journal.pgen.1007194. PMID: 29447163 Free PMC Article

Familial and hereditary prostate cancer by definition in an italian surgical series: clinical features and outcome.

Sacco E, Prayer-Galetti T, Pinto F, Ciaccia M, Fracalanza S, Betto G, Pagano F
Eur Urol 2005 Jun;47(6):761-8. Epub 2005 Feb 9 doi: 10.1016/j.eururo.2005.01.016. PMID: 15925070

Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk.

Chang BL, Zheng SL, Hawkins GA, Isaacs SD, Wiley KE, Turner A, Carpten JD, Bleecker ER, Walsh PC, Trent JM, Meyers DA, Isaacs WB, Xu J
Hum Genet 2002 Feb;110(2):122-9. Epub 2002 Jan 23 doi: 10.1007/s00439-001-0662-6. PMID: 11935317

Hereditary prostate cancer and other genetic predispositions to prostate cancer.

Cussenot O, Valeri A, Berthon P, Fournier G, Mangin P
Urol Int 1998;60 Suppl 2:30-4; discussion 35. doi: 10.1159/000056549. PMID: 9607556

See all (4)

Diagnosis

Familial and hereditary prostate cancer by definition in an italian surgical series: clinical features and outcome.

Sacco E, Prayer-Galetti T, Pinto F, Ciaccia M, Fracalanza S, Betto G, Pagano F
Eur Urol 2005 Jun;47(6):761-8. Epub 2005 Feb 9 doi: 10.1016/j.eururo.2005.01.016. PMID: 15925070

See all (1)

Prognosis

Familial and hereditary prostate cancer by definition in an italian surgical series: clinical features and outcome.

Sacco E, Prayer-Galetti T, Pinto F, Ciaccia M, Fracalanza S, Betto G, Pagano F
Eur Urol 2005 Jun;47(6):761-8. Epub 2005 Feb 9 doi: 10.1016/j.eururo.2005.01.016. PMID: 15925070

Hereditary prostate cancer and other genetic predispositions to prostate cancer.

Cussenot O, Valeri A, Berthon P, Fournier G, Mangin P
Urol Int 1998;60 Suppl 2:30-4; discussion 35. doi: 10.1159/000056549. PMID: 9607556

See all (2)