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Infant-type hemispheric glioma

MedGen UID:
1806401
•Concept ID:
C5669919
•
Neoplastic Process
Synonyms: Infant-Type Hemispheric Glioma; infant-type hemispheric glioma
 
Monarch Initiative: MONDO:0858940

Definition

A high-grade cellular astrocytoma that arises in the cerebral hemisphere and occurs in early childhood. It is characterized by receptor tyrosine kinase fusions in the NTRK family, ROS1, ALK, or MET genes. It includes the following subtypes: infant-type hemispheric glioma, NTRK-altered, infant-type hemispheric glioma, ROS1-altered, infant-type hemispheric glioma, ALK-altered, and infant-type hemispheric glioma, MET-altered. [from NCI]

Professional guidelines

PubMed

Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy.
Zuckermann M, He C, Andrews J, Bagchi A, Sloan-Henry R, Bianski B, Xie J, Wang Y, Twarog N, Onar-Thomas A, Ernst KJ, Yang L, Li Y, Zhu X, Ocasio JK, Budd KM, Dalton J, Li X, Chepyala D, Zhang J, Xu K, Hover L, Roach JT, Chan KC, Hofmann N, McKinnon PJ, Pfister SM, Shelat AA, Rankovic Z, Freeman BB 3rd, Chiang J, Jones DTW, Tinkle CL, Baker SJ
Mol Cancer 2024 Jun 7;23(1):123. doi: 10.1186/s12943-024-02027-6. PMID: 38849845Free PMC Article
A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant-type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma.
Tauziède-Espariat A, Beccaria K, Dangouloff-Ros V, Sievers P, Meurgey A, Pissaloux D, Appay R, Saffroy R, Grill J, Mariet C, Bourdeaut F, Hasty L, Métais A, Chrétien F, Blauwblomme T, Puget S, Boddaert N, Varlet P; RENOCLIP-LOC
Brain Pathol 2023 Sep;33(5):e13182. Epub 2023 Jun 22 doi: 10.1111/bpa.13182. PMID: 37349135Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Central Nervous System Cancers, 2024

Recent clinical studies

Etiology

High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience.
Chiang J, Bagchi A, Li X, Dhanda SK, Huang J, Pinto SN, Sioson E, Dalton J, Tatevossian RG, Jia S, Partap S, Fisher PG, Bowers DC, Hassall TEG, Lu C, Zaldivar-Peraza A, Wright KD, Broniscer A, Qaddoumi I, Upadhyaya SA, Vinitsky A, Sabin ND, Orr BA, Klimo P Jr, Boop FA, Ashford JM, Conklin HM, Onar-Thomas A, Zhou X, Ellison DW, Gajjar A, Robinson GW
Neuro Oncol 2024 Jan 5;26(1):178-190. doi: 10.1093/neuonc/noad130. PMID: 37503880Free PMC Article
ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.
Meredith DM, Cooley LD, Dubuc A, Morrissette J, Sussman RT, Nasrallah MP, Rathbun P, Yap KL, Wadhwani N, Bao L, Wolff DJ, Ida C, Sukhanova M, Horbinski C, Jennings LJ, Farooqi M, Gener M, Ginn K, Kam KL, Sasaki K, Kanagal-Shamanna R, Alexandrescu S, Brat D, Lu X
Mod Pathol 2023 Nov;36(11):100294. Epub 2023 Jul 31 doi: 10.1016/j.modpat.2023.100294. PMID: 37532182
A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant-type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma.
Tauziède-Espariat A, Beccaria K, Dangouloff-Ros V, Sievers P, Meurgey A, Pissaloux D, Appay R, Saffroy R, Grill J, Mariet C, Bourdeaut F, Hasty L, Métais A, Chrétien F, Blauwblomme T, Puget S, Boddaert N, Varlet P; RENOCLIP-LOC
Brain Pathol 2023 Sep;33(5):e13182. Epub 2023 Jun 22 doi: 10.1111/bpa.13182. PMID: 37349135Free PMC Article
Gliomas in children and adolescents: investigation of molecular alterations with a potential prognostic and therapeutic impact.
Cabral de Carvalho Corrêa D, Tesser-Gamba F, Dias Oliveira I, Saba da Silva N, Capellano AM, de Seixas Alves MT, Dastoli PA, Cavalheiro S, Caminada de Toledo SR
J Cancer Res Clin Oncol 2022 Jan;148(1):107-119. Epub 2021 Oct 9 doi: 10.1007/s00432-021-03813-1. PMID: 34626238

Diagnosis

All-in-one bimodal DNA and RNA next-generation sequencing panel for integrative diagnosis of glioma.
Higa N, Akahane T, Kirishima M, Yonezawa H, Makino R, Uchida H, Yokoyama S, Takajo T, Otsuji R, Fujioka Y, Sangatsuda Y, Kuga D, Yamahata H, Hata N, Horie N, Kurosaki M, Yamamoto J, Yoshimoto K, Tanimoto A, Hanaya R
Pathol Res Pract 2024 Nov;263:155598. Epub 2024 Sep 28 doi: 10.1016/j.prp.2024.155598. PMID: 39357189
A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity.
Gorodezki D, Chiang J, Viaene AN, Sievers P, Schmid S, Holzer U, Paulsen F, Schuhmann MU, Witt O, Schittenhelm J, Ebinger M
Acta Neuropathol Commun 2024 Jun 21;12(1):101. doi: 10.1186/s40478-024-01817-9. PMID: 38902810Free PMC Article
High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience.
Chiang J, Bagchi A, Li X, Dhanda SK, Huang J, Pinto SN, Sioson E, Dalton J, Tatevossian RG, Jia S, Partap S, Fisher PG, Bowers DC, Hassall TEG, Lu C, Zaldivar-Peraza A, Wright KD, Broniscer A, Qaddoumi I, Upadhyaya SA, Vinitsky A, Sabin ND, Orr BA, Klimo P Jr, Boop FA, Ashford JM, Conklin HM, Onar-Thomas A, Zhou X, Ellison DW, Gajjar A, Robinson GW
Neuro Oncol 2024 Jan 5;26(1):178-190. doi: 10.1093/neuonc/noad130. PMID: 37503880Free PMC Article
2021 updates to the World Health Organization classification of adult-type and pediatric-type diffuse gliomas: a clinical practice review.
Thomas DL
Chin Clin Oncol 2023 Feb;12(1):7. doi: 10.21037/cco-22-120. PMID: 36922356
Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.
Gianno F, Giovannoni I, Cafferata B, Diomedi-Camassei F, Minasi S, Barresi S, Buttarelli FR, Alesi V, Cardoni A, Antonelli M, Puggioni C, Colafati GS, Carai A, Vinci M, Mastronuzzi A, Miele E, Alaggio R, Giangaspero F, Rossi S
Pathologica 2022 Dec;114(6):422-435. doi: 10.32074/1591-951X-830. PMID: 36534421Free PMC Article

Therapy

Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy.
Zuckermann M, He C, Andrews J, Bagchi A, Sloan-Henry R, Bianski B, Xie J, Wang Y, Twarog N, Onar-Thomas A, Ernst KJ, Yang L, Li Y, Zhu X, Ocasio JK, Budd KM, Dalton J, Li X, Chepyala D, Zhang J, Xu K, Hover L, Roach JT, Chan KC, Hofmann N, McKinnon PJ, Pfister SM, Shelat AA, Rankovic Z, Freeman BB 3rd, Chiang J, Jones DTW, Tinkle CL, Baker SJ
Mol Cancer 2024 Jun 7;23(1):123. doi: 10.1186/s12943-024-02027-6. PMID: 38849845Free PMC Article
An Infant-Type Hemispheric Glioma With SOX5::ALK: A Novel Fusion.
Tsai CC, Huang MH, Fang CL, Hsieh KL, Hsieh TH, Ho WL, Chang H, Tsai ML, Kao YC, Miser JS, Wong TT, Su MY, Liu YL
J Natl Compr Canc Netw 2024 Feb;22(1) doi: 10.6004/jnccn.2023.7102. PMID: 38394779
Lorlatinib for ALK-fused, infant-type hemispheric glioma with lung metastasis: a case report.
Lai M, Li S, Li H, Hu Q, Li J, Zhou J, Ai R, Zhen J, Zhou Z, Wang L, Zhang Y, Hu W, Yuan L, Ma X, Zhang X, Song C, Li Z, Cai L
Ann Clin Transl Neurol 2023 May;10(5):836-841. Epub 2023 Mar 31 doi: 10.1002/acn3.51766. PMID: 37000961Free PMC Article
Clinical and Molecular Evolution of an ALK-Driven Infant-Type Hemispheric Glioma Treated Sequentially With Second- and Third-Generation Anaplastic Lymphoma Kinase Inhibitors.
Gene-Olaciregui N, Perez-Somarriba M, Santa-María V, Cruz O, Gómez-González S, Castañeda A, Suñol M, Rovira C, Muchart J, Hinojosa J, La Madrid AM, Lavarino C
JCO Precis Oncol 2023 Mar;7:e2200547. doi: 10.1200/PO.22.00547. PMID: 36996378
Lorlatinib for the Treatment of ALK Fusion-Positive Infant-Type Hemispheric Glioma: A Case Report.
Greenwell AM, Baughan S, Altinok D, Marupudi NI, Kupsky W, Kumar-Sinha C, Gorsi HS
JCO Precis Oncol 2022 Oct;6:e2200255. doi: 10.1200/PO.22.00255. PMID: 36315913

Prognosis

2021 updates to the World Health Organization classification of adult-type and pediatric-type diffuse gliomas: a clinical practice review.
Thomas DL
Chin Clin Oncol 2023 Feb;12(1):7. doi: 10.21037/cco-22-120. PMID: 36922356
Gliomas in children and adolescents: investigation of molecular alterations with a potential prognostic and therapeutic impact.
Cabral de Carvalho Corrêa D, Tesser-Gamba F, Dias Oliveira I, Saba da Silva N, Capellano AM, de Seixas Alves MT, Dastoli PA, Cavalheiro S, Caminada de Toledo SR
J Cancer Res Clin Oncol 2022 Jan;148(1):107-119. Epub 2021 Oct 9 doi: 10.1007/s00432-021-03813-1. PMID: 34626238

Clinical prediction guides

An Infant-Type Hemispheric Glioma With SOX5::ALK: A Novel Fusion.
Tsai CC, Huang MH, Fang CL, Hsieh KL, Hsieh TH, Ho WL, Chang H, Tsai ML, Kao YC, Miser JS, Wong TT, Su MY, Liu YL
J Natl Compr Canc Netw 2024 Feb;22(1) doi: 10.6004/jnccn.2023.7102. PMID: 38394779
Gliomas in children and adolescents: investigation of molecular alterations with a potential prognostic and therapeutic impact.
Cabral de Carvalho Corrêa D, Tesser-Gamba F, Dias Oliveira I, Saba da Silva N, Capellano AM, de Seixas Alves MT, Dastoli PA, Cavalheiro S, Caminada de Toledo SR
J Cancer Res Clin Oncol 2022 Jan;148(1):107-119. Epub 2021 Oct 9 doi: 10.1007/s00432-021-03813-1. PMID: 34626238

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Central Nervous System Cancers, 2024

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