U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Prostate Small Cell Carcinoma

MedGen UID:
1674106
•Concept ID:
C4763838
•
Neoplastic Process
Synonyms: Metastatic Prostate Small Cell Neuroendocrine Carcinoma; Metastatic Small Cell Neuroendocrine Prostate Cancer; Metastatic Small Cell Prostate Cancer

Definition

Prostate small cell neuroendocrine carcinoma that has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Metastatic Prostate Small Cell Carcinoma

Professional guidelines

PubMed

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Transcriptional mediators of treatment resistance in lethal prostate cancer.
He MX, Cuoco MS, Crowdis J, Bosma-Moody A, Zhang Z, Bi K, Kanodia A, Su MJ, Ku SY, Garcia MM, Sweet AR, Rodman C, DelloStritto L, Silver R, Steinharter J, Shah P, Izar B, Walk NC, Burke KP, Bakouny Z, Tewari AK, Liu D, Camp SY, Vokes NI, Salari K, Park J, Vigneau S, Fong L, Russo JW, Yuan X, Balk SP, Beltran H, Rozenblatt-Rosen O, Regev A, Rotem A, Taplin ME, Van Allen EM
Nat Med 2021 Mar;27(3):426-433. Epub 2021 Mar 4 doi: 10.1038/s41591-021-01244-6. PMID: 33664492Free PMC Article
Bladder cancer.
Montie JE, Clark PE, Eisenberger MA, El-Galley R, Greenberg RE, Herr HW, Hudes GR, Kuban DA, Kuzel TM, Lange PH, Lele SM, Michalski J, Patterson A, Pohar KS, Richie JP, Sexton WJ, Shipley WU, Small EJ, Trump DL, Walther PJ, Wilson TG; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2009 Jan;7(1):8-39. doi: 10.6004/jnccn.2009.0002. PMID: 19176203

Recent clinical studies

Etiology

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Immunogenomic Landscape of Neuroendocrine Prostate Cancer.
Bhinder B, Ferguson A, Sigouros M, Uppal M, Elsaeed AG, Bareja R, Alnajar H, Eng KW, Conteduca V, Sboner A, Mosquera JM, Elemento O, Beltran H
Clin Cancer Res 2023 Aug 1;29(15):2933-2943. doi: 10.1158/1078-0432.CCR-22-3743. PMID: 37223924Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ
J Clin Oncol 2018 Aug 20;36(24):2492-2503. Epub 2018 Jul 9 doi: 10.1200/JCO.2017.77.6880. PMID: 29985747Free PMC Article

Diagnosis

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Evolving concepts in prostatic neuroendocrine manifestations: from focal divergent differentiation to amphicrine carcinoma.
Bellur S, Van der Kwast T, Mete O
Hum Pathol 2019 Mar;85:313-327. Epub 2018 Nov 24 doi: 10.1016/j.humpath.2018.11.016. PMID: 30481509
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Small cell carcinoma of the prostate.
Nadal R, Schweizer M, Kryvenko ON, Epstein JI, Eisenberger MA
Nat Rev Urol 2014 Apr;11(4):213-9. Epub 2014 Feb 18 doi: 10.1038/nrurol.2014.21. PMID: 24535589Free PMC Article

Therapy

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ
J Clin Oncol 2018 Aug 20;36(24):2492-2503. Epub 2018 Jul 9 doi: 10.1200/JCO.2017.77.6880. PMID: 29985747Free PMC Article

Prognosis

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article

Clinical prediction guides

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer.
Cavalheri V, Burtin C, Formico VR, Nonoyama ML, Jenkins S, Spruit MA, Hill K
Cochrane Database Syst Rev 2019 Jun 17;6(6):CD009955. doi: 10.1002/14651858.CD009955.pub3. PMID: 31204439Free PMC Article
Evolving concepts in prostatic neuroendocrine manifestations: from focal divergent differentiation to amphicrine carcinoma.
Bellur S, Van der Kwast T, Mete O
Hum Pathol 2019 Mar;85:313-327. Epub 2018 Nov 24 doi: 10.1016/j.humpath.2018.11.016. PMID: 30481509
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL
J Clin Oncol 2010 Jul 1;28(19):3167-75. Epub 2010 Jun 1 doi: 10.1200/JCO.2009.26.7609. PMID: 20516446Free PMC Article

Recent systematic reviews

A Systematic Review on the Diagnostic Value of Fibroblast Activation Protein Inhibitor PET/CT in Genitourinary Cancers.
Hagens MJ, van Leeuwen PJ, Wondergem M, Boellaard TN, Sanguedolce F, Oprea-Lager DE, Bex A, Vis AN, van der Poel HG, Mertens LS; EAU Section of Urological Imaging
J Nucl Med 2024 Jun 3;65(6):888-896. doi: 10.2967/jnumed.123.267260. PMID: 38637140
Endocrine and paracrine characteristics of neuroendocrine prostate cancer.
Arman T, Nelson PS
Front Endocrinol (Lausanne) 2022;13:1012005. Epub 2022 Nov 11 doi: 10.3389/fendo.2022.1012005. PMID: 36440195Free PMC Article
A Systematic Review of the Cost-Effectiveness of Stereotactic Radiation Therapy for Cancer Oligometastases.
Verma V, Yegya-Raman N, Sprave T, Han G, Kantarjian HM, Welsh JW, Chang JY, Lin SH
Int J Radiat Oncol Biol Phys 2022 Dec 1;114(5):977-988. Epub 2022 Jun 5 doi: 10.1016/j.ijrobp.2022.05.042. PMID: 35675852
Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer.
Cavalheri V, Burtin C, Formico VR, Nonoyama ML, Jenkins S, Spruit MA, Hill K
Cochrane Database Syst Rev 2019 Jun 17;6(6):CD009955. doi: 10.1002/14651858.CD009955.pub3. PMID: 31204439Free PMC Article
Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories.
Porter LH, Lawrence MG, Ilic D, Clouston D, Bolton DM, Frydenberg M, Murphy DG, Pezaro C, Risbridger GP, Taylor RA
Eur Urol 2017 Oct;72(4):492-495. Epub 2017 Mar 22 doi: 10.1016/j.eururo.2017.03.013. PMID: 28342640

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...