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EEG with abnormally slow frequencies

MedGen UID:
869053
•Concept ID:
C4023471
•
Pathologic Function
HPO: HP:0011203

Definition

EEG with abnormally slow frequencies. [from HPO]

Conditions with this feature

Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities
MedGen UID:
1672905
•Concept ID:
C5193124
•
Disease or Syndrome
Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities (HIDEA) is an autosomal recessive neurodevelopmental syndrome characterized by global developmental delay, poor or absent speech, hypotonia, variable ocular movement and visual abnormalities, and respiratory difficulties, including hypoventilation, and sleep apnea. Patients may have significant breathing problems during respiratory infections that may lead to early death (summary by Rahikkala et al., 2019).
See: Condition Record
Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities

Professional guidelines

PubMed

Evaluating fenfluramine hydrochloride as an oral solution for the treatment of seizures associated with Lennox-Gastaut syndrome.
Besag FMC, Vasey MJ, Chin RFM
Expert Rev Neurother 2024 Mar;24(3):235-249. Epub 2024 Feb 7 doi: 10.1080/14737175.2024.2313548. PMID: 38315124
Proposed anti-seizure medication combinations with rufinamide in the treatment of Lennox-Gastaut syndrome: Narrative review and expert opinion.
Sankar R, Chez M, Pina-Garza JE, Dixon-Salazar T, Flamini JR, Hyslop A, McGoldrick P, Millichap JJ, Resnick T, Rho JM, Wolf S
Seizure 2023 Aug;110:42-57. Epub 2023 May 25 doi: 10.1016/j.seizure.2023.05.018. PMID: 37321047
Autoimmune Encephalitis Related to Cancer Treatment With Immune Checkpoint Inhibitors: A Systematic Review.
Nersesjan V, McWilliam O, Krarup LH, Kondziella D
Neurology 2021 Jul 13;97(2):e191-e202. Epub 2021 May 5 doi: 10.1212/WNL.0000000000012122. PMID: 33952651

Recent clinical studies

Etiology

Electroencephalography in young onset dementia.
Brown CW, Chen HY, Panegyres PK
BMC Neurol 2023 May 23;23(1):202. doi: 10.1186/s12883-023-03248-w. PMID: 37221470Free PMC Article
Sleep-disordered breathing and sleep macro- and micro-architecture in children with Down syndrome.
Sibarani CR, Walter LM, Davey MJ, Nixon GM, Horne RSC
Pediatr Res 2022 Apr;91(5):1248-1256. Epub 2021 Jul 6 doi: 10.1038/s41390-021-01642-z. PMID: 34230620
Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies.
van der Zande JJ, Gouw AA, van Steenoven I, van de Beek M, Scheltens P, Stam CJ, Lemstra AW
Neurology 2020 Aug 11;95(6):e662-e670. Epub 2020 Jul 7 doi: 10.1212/WNL.0000000000009977. PMID: 32636325
Invasive Evaluations for Epilepsy Surgery: A Review of the Literature.
Enatsu R, Mikuni N
Neurol Med Chir (Tokyo) 2016 May 15;56(5):221-7. Epub 2016 Mar 4 doi: 10.2176/nmc.ra.2015-0319. PMID: 26948700Free PMC Article
The EEG in centenarians.
Hubbard O, Sunde D, Goldensohn ES
Electroencephalogr Clin Neurophysiol 1976 Apr;40(4):407-17. doi: 10.1016/0013-4694(76)90192-9. PMID: 56267

Diagnosis

Electroencephalography in young onset dementia.
Brown CW, Chen HY, Panegyres PK
BMC Neurol 2023 May 23;23(1):202. doi: 10.1186/s12883-023-03248-w. PMID: 37221470Free PMC Article
Long-term outcome of developmental and epileptic encephalopathies.
Van Bogaert P
Rev Neurol (Paris) 2022 Sep;178(7):659-665. Epub 2022 Apr 27 doi: 10.1016/j.neurol.2022.01.009. PMID: 35489823
Clinical neurophysiology of migraine with aura.
Coppola G, Di Lorenzo C, Parisi V, Lisicki M, Serrao M, Pierelli F
J Headache Pain 2019 Apr 29;20(1):42. doi: 10.1186/s10194-019-0997-9. PMID: 31035929Free PMC Article
Infantile spasms.
Hrachovy RA, Frost JD Jr
Handb Clin Neurol 2013;111:611-8. doi: 10.1016/B978-0-444-52891-9.00063-4. PMID: 23622208
Diagnosis and subtyping of depressive disorders by quantitative electroencephalography: II. Interhemispheric measures are abnormal in major depressives and frequency analysis may discriminate certain subtypes.
Lieber AL
Hillside J Clin Psychiatry 1988;10(1):84-97. PMID: 3410406

Therapy

Autoimmune Encephalitis Related to Cancer Treatment With Immune Checkpoint Inhibitors: A Systematic Review.
Nersesjan V, McWilliam O, Krarup LH, Kondziella D
Neurology 2021 Jul 13;97(2):e191-e202. Epub 2021 May 5 doi: 10.1212/WNL.0000000000012122. PMID: 33952651
Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies.
van der Zande JJ, Gouw AA, van Steenoven I, van de Beek M, Scheltens P, Stam CJ, Lemstra AW
Neurology 2020 Aug 11;95(6):e662-e670. Epub 2020 Jul 7 doi: 10.1212/WNL.0000000000009977. PMID: 32636325
Idiopathic focal epilepsies: the "lost tribe".
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M
Epileptic Disord 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. PMID: 27435520
Epileptic encephalopathy with continuous spikes and waves during sleep.
Striano P, Capovilla G
Curr Neurol Neurosci Rep 2013 Jul;13(7):360. doi: 10.1007/s11910-013-0360-5. PMID: 23666433
Reduction of cortical myoclonus-related epileptic activity following slow-frequency rTMS.
Rossi S, Ulivelli M, Bartalini S, Galli R, Passero S, Battistini N, Vatti G
Neuroreport 2004 Feb 9;15(2):293-6. doi: 10.1097/00001756-200402090-00016. PMID: 15076755

Prognosis

Electroencephalography in young onset dementia.
Brown CW, Chen HY, Panegyres PK
BMC Neurol 2023 May 23;23(1):202. doi: 10.1186/s12883-023-03248-w. PMID: 37221470Free PMC Article
Anti-amphiphysin encephalitis: Expanding the clinical spectrum.
Sun Y, Qin X, Huang D, Zhou Z, Zhang Y, Wang Q
Front Immunol 2023;14:1084883. Epub 2023 Apr 5 doi: 10.3389/fimmu.2023.1084883. PMID: 37090693Free PMC Article
Diagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies.
van der Zande JJ, Gouw AA, van Steenoven I, van de Beek M, Scheltens P, Stam CJ, Lemstra AW
Neurology 2020 Aug 11;95(6):e662-e670. Epub 2020 Jul 7 doi: 10.1212/WNL.0000000000009977. PMID: 32636325
Idiopathic focal epilepsies: the "lost tribe".
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M
Epileptic Disord 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. PMID: 27435520
Epileptic encephalopathy with continuous spikes and waves during sleep.
Striano P, Capovilla G
Curr Neurol Neurosci Rep 2013 Jul;13(7):360. doi: 10.1007/s11910-013-0360-5. PMID: 23666433

Clinical prediction guides

Epilepsy as a Novel Phenotype of BPTF-Related Disorders.
Ferretti A, Furlan M, Glinton KE, Fenger CD, Boschann F, Amlie-Wolf L, Zeidler S, Moretti R, Stoltenburg C, Tarquinio DC, Furia F, Parisi P, Rubboli G, Devinsky O, Mignot C, Gripp KW, Møller RS, Yang Y, Stankiewicz P, Gardella E
Pediatr Neurol 2024 Sep;158:17-25. Epub 2024 Jun 11 doi: 10.1016/j.pediatrneurol.2024.06.001. PMID: 38936258
Electroencephalography in young onset dementia.
Brown CW, Chen HY, Panegyres PK
BMC Neurol 2023 May 23;23(1):202. doi: 10.1186/s12883-023-03248-w. PMID: 37221470Free PMC Article
The clinical features of familial focal epilepsy with variable foci and NPRL3 gene variant.
Wang Y, Yu P, Zhu G, Wu X, Ding D, Hong Z
PLoS One 2023;18(4):e0284924. Epub 2023 Apr 26 doi: 10.1371/journal.pone.0284924. PMID: 37099548Free PMC Article
Clinical neurophysiology of migraine with aura.
Coppola G, Di Lorenzo C, Parisi V, Lisicki M, Serrao M, Pierelli F
J Headache Pain 2019 Apr 29;20(1):42. doi: 10.1186/s10194-019-0997-9. PMID: 31035929Free PMC Article
The EEG in centenarians.
Hubbard O, Sunde D, Goldensohn ES
Electroencephalogr Clin Neurophysiol 1976 Apr;40(4):407-17. doi: 10.1016/0013-4694(76)90192-9. PMID: 56267

Recent systematic reviews

Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia.
Jiang Y, Neal J, Sompol P, Yener G, Arakaki X, Norris CM, Farina FR, Ibanez A, Lopez S, Al-Ezzi A, Kavcic V, Güntekin B, Babiloni C, Hajós M
Alzheimers Dement 2024 Oct;20(10):7296-7319. Epub 2024 Aug 29 doi: 10.1002/alz.14089. PMID: 39206795Free PMC Article
Autoimmune Encephalitis Related to Cancer Treatment With Immune Checkpoint Inhibitors: A Systematic Review.
Nersesjan V, McWilliam O, Krarup LH, Kondziella D
Neurology 2021 Jul 13;97(2):e191-e202. Epub 2021 May 5 doi: 10.1212/WNL.0000000000012122. PMID: 33952651
Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review.
Roberto KT, Espiritu AI, Fernandez MLL, Gutierrez JC
Epilepsy Behav 2020 Nov;112:107462. Epub 2020 Sep 22 doi: 10.1016/j.yebeh.2020.107462. PMID: 32971385
Polysomnographically measured sleep changes in idiopathic REM sleep behavior disorder: A systematic review and meta-analysis.
Zhang Y, Ren R, Yang L, Sanford LD, Tang X
Sleep Med Rev 2020 Dec;54:101362. Epub 2020 Jul 13 doi: 10.1016/j.smrv.2020.101362. PMID: 32739826
Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis.
Xue-Ping W, Hai-Jiao W, Li-Na Z, Xu D, Ling L
Medicine (Baltimore) 2019 Jul;98(30):e16402. doi: 10.1097/MD.0000000000016402. PMID: 31348240Free PMC Article

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