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Macular schisis

MedGen UID:
868910
•Concept ID:
C4023321
•
Disease or Syndrome
HPO: HP:0011511

Definition

Splitting of the retina in the macular region. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Macular schisis

Professional guidelines

PubMed

Stellate nonhereditary idiopathic foveomacular retinoschisis and an approach to the differential diagnosis of macular star.
Light JG, Pyfer MS, Salabati M, Mahmoudzadeh R, Wakabayashi T, Ho AC
Curr Opin Ophthalmol 2022 May 1;33(3):157-166. Epub 2022 Mar 2 doi: 10.1097/ICU.0000000000000844. PMID: 35239516

Recent clinical studies

Etiology

Retinal and Vitreous Changes Associated with Spontaneous Improvement in Myopic Macular Schisis.
Goudot M, Couturier A, Beaumont W, Gaudric A, Tadayoni R, Philippakis E
Ophthalmol Retina 2024 Dec;8(12):1192-1199. Epub 2024 Jun 29 doi: 10.1016/j.oret.2024.06.017. PMID: 38950656
Characterization and diagnosis of retinoschisis and schisis detachments using spectral domain optical coherence tomography.
Jalalizadeh RA, Smith BT
Graefes Arch Clin Exp Ophthalmol 2023 Feb;261(2):375-380. Epub 2022 Aug 19 doi: 10.1007/s00417-022-05801-8. PMID: 35984486
Macular buckle without vitrectomy for myopic macular schisis: a Canadian case series.
Grewal PS, Lapere SRJ, Gupta RR, Greve M
Can J Ophthalmol 2019 Feb;54(1):60-64. Epub 2018 May 3 doi: 10.1016/j.jcjo.2018.02.014. PMID: 30851775
Peripapillary schisis in open-angle glaucoma.
Dhingra N, Manoharan R, Gill S, Nagar M
Eye (Lond) 2017 Mar;31(3):499-502. Epub 2016 Nov 11 doi: 10.1038/eye.2016.235. PMID: 27834967Free PMC Article
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Diagnosis

Characterization and diagnosis of retinoschisis and schisis detachments using spectral domain optical coherence tomography.
Jalalizadeh RA, Smith BT
Graefes Arch Clin Exp Ophthalmol 2023 Feb;261(2):375-380. Epub 2022 Aug 19 doi: 10.1007/s00417-022-05801-8. PMID: 35984486
New-Onset Macular Schisis in a Patient With Glaucoma.
Wilke GA, O'Bryhim BE, Apte RS
JAMA Ophthalmol 2021 Nov 1;139(11):1236-1237. doi: 10.1001/jamaophthalmol.2021.0939. PMID: 34473207
Bilateral Optic Nerve Coloboma and Macular Schisis in Papillorenal Syndrome.
Rahimy E, Rahimy E
Ophthalmology 2016 May;123(5):990. doi: 10.1016/j.ophtha.2016.02.039. PMID: 27107352
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Macular schisis and detachment secondary to large optic nerve head cup: a newly recognized syndrome amenable to vitrectomy.
Mavrikakis E, Lam WC
Acta Ophthalmol 2011 Feb;89(1):95-6. doi: 10.1111/j.1755-3768.2009.01553.x. PMID: 19549105

Therapy

Comparison of macular buckling and vitrectomy for the treatment of macular schisis and associated macular detachment in high myopia: a randomized clinical trial.
Liu B, Chen S, Li Y, Lian P, Zhao X, Yu X, Li T, Jin C, Liang X, Huang SS, Lu L
Acta Ophthalmol 2020 May;98(3):e266-e272. Epub 2019 Nov 17 doi: 10.1111/aos.14260. PMID: 31736279Free PMC Article
Diurnal variations of foveoschisis by optical coherence tomography in patients with RS1 X-linked juvenile retinoschisis.
Abalem MF, Musch DC, Birch DG, Pennesi ME, Heckenlively JR, Jayasundera T
Ophthalmic Genet 2018 Aug;39(4):437-442. Epub 2018 Jun 14 doi: 10.1080/13816810.2018.1466340. PMID: 29902095Free PMC Article
The development and evolution of full thickness macular hole in highly myopic eyes.
Lin CW, Ho TC, Yang CM
Eye (Lond) 2015 Mar;29(3):388-96. Epub 2015 Jan 9 doi: 10.1038/eye.2014.312. PMID: 25572579Free PMC Article
Vitrectomy for optic disk pit with macular schisis and outer retinal dehiscence.
Shukla D, Kalliath J, Tandon M, Vijayakumar B
Retina 2012 Jul;32(7):1337-42. doi: 10.1097/IAE.0b013e318235d8fc. PMID: 22481474
Macular schisis and detachment secondary to large optic nerve head cup: a newly recognized syndrome amenable to vitrectomy.
Mavrikakis E, Lam WC
Acta Ophthalmol 2011 Feb;89(1):95-6. doi: 10.1111/j.1755-3768.2009.01553.x. PMID: 19549105

Prognosis

Retinal and Vitreous Changes Associated with Spontaneous Improvement in Myopic Macular Schisis.
Goudot M, Couturier A, Beaumont W, Gaudric A, Tadayoni R, Philippakis E
Ophthalmol Retina 2024 Dec;8(12):1192-1199. Epub 2024 Jun 29 doi: 10.1016/j.oret.2024.06.017. PMID: 38950656
Vitreomacular traction in diabetic retinopathy.
Hsieh YT, Yang CM
Jpn J Ophthalmol 2024 Jan;68(1):12-18. Epub 2023 Nov 25 doi: 10.1007/s10384-023-01034-2. PMID: 38001367
Macular buckle without vitrectomy for myopic macular schisis: a Canadian case series.
Grewal PS, Lapere SRJ, Gupta RR, Greve M
Can J Ophthalmol 2019 Feb;54(1):60-64. Epub 2018 May 3 doi: 10.1016/j.jcjo.2018.02.014. PMID: 30851775
Peripapillary schisis in open-angle glaucoma.
Dhingra N, Manoharan R, Gill S, Nagar M
Eye (Lond) 2017 Mar;31(3):499-502. Epub 2016 Nov 11 doi: 10.1038/eye.2016.235. PMID: 27834967Free PMC Article
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Clinical prediction guides

Retinal and Vitreous Changes Associated with Spontaneous Improvement in Myopic Macular Schisis.
Goudot M, Couturier A, Beaumont W, Gaudric A, Tadayoni R, Philippakis E
Ophthalmol Retina 2024 Dec;8(12):1192-1199. Epub 2024 Jun 29 doi: 10.1016/j.oret.2024.06.017. PMID: 38950656
Clinical and Genetic Features of NR2E3-Associated Retinopathy: A Report of Eight Families with a Longitudinal Study and Literature Review.
Xiao S, Yi Z, Xiao X, Li S, Jia X, Lian P, Sun W, Wang P, Lu L, Zhang Q
Genes (Basel) 2023 Jul 26;14(8) doi: 10.3390/genes14081525. PMID: 37628579Free PMC Article
Clinical and genetic features of retinoschisis in 120 families with RS1 mutations.
Xiao S, Sun W, Xiao X, Li S, Luo H, Jia X, Ouyang J, Li X, Wang Y, Jiang Y, Wang P, Zhang Q
Br J Ophthalmol 2023 Mar;107(3):367-372. Epub 2021 Oct 13 doi: 10.1136/bjophthalmol-2021-319668. PMID: 34645606
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Spontaneous improvement of macular traction retinal detachment associated with myopic macular schisis.
Goldman DR, Duker JS
Ophthalmic Surg Lasers Imaging Retina 2013 Sep-Oct;44(5):497-8. doi: 10.3928/23258160-20130909-15. PMID: 24044716

Recent systematic reviews

Clinical and Genetic Features of NR2E3-Associated Retinopathy: A Report of Eight Families with a Longitudinal Study and Literature Review.
Xiao S, Yi Z, Xiao X, Li S, Jia X, Lian P, Sun W, Wang P, Lu L, Zhang Q
Genes (Basel) 2023 Jul 26;14(8) doi: 10.3390/genes14081525. PMID: 37628579Free PMC Article

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