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Hyperplastic colonic polyposis

MedGen UID:
868611
•Concept ID:
C4023010
•
Neoplastic Process
HPO: HP:0012183

Definition

Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Hyperplastic colonic polyposis

Conditions with this feature

Polyposis syndrome, hereditary mixed, 2
MedGen UID:
350500
•Concept ID:
C1864730
•
Disease or Syndrome
Hereditary mixed polyposis syndrome-2 (HMPS2) is characterized by colonic polyps of mixed hyperplastic, adenomatous, and occasional juvenile types. Polyposis eventually progresses to colorectal cancer (Cao et al., 2006). For a discussion of genetic heterogeneity of HMPS, see HMPS1 (601228).
See: Condition Record
Polyposis syndrome, hereditary mixed, 2

Professional guidelines

PubMed

Serrated Lesions in Inflammatory Bowel Disease: Genotype-Phenotype Correlation.
Brcic I, Dawson H, Gröchenig HP, Högenauer C, Kashofer K
Int J Surg Pathol 2021 Feb;29(1):46-53. Epub 2020 Oct 8 doi: 10.1177/1066896920963798. PMID: 33030071
Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance.
East JE, Vieth M, Rex DK
Gut 2015 Jun;64(6):991-1000. Epub 2015 Mar 6 doi: 10.1136/gutjnl-2014-309041. PMID: 25748647
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article

Recent clinical studies

Etiology

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Gastritis, Gastric Polyps and Gastric Cancer.
Waldum H, Fossmark R
Int J Mol Sci 2021 Jun 18;22(12) doi: 10.3390/ijms22126548. PMID: 34207192Free PMC Article
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article
The biology of colorectal carcinoma.
Jessup JM, Gallick GE
Curr Probl Cancer 1992 Sep-Oct;16(5):261-328. PMID: 1337732

Diagnosis

Serrated polyposis syndrome; epidemiology and management.
Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance.
East JE, Vieth M, Rex DK
Gut 2015 Jun;64(6):991-1000. Epub 2015 Mar 6 doi: 10.1136/gutjnl-2014-309041. PMID: 25748647
Role of the serrated pathway in colorectal cancer pathogenesis.
Leggett B, Whitehall V
Gastroenterology 2010 Jun;138(6):2088-100. doi: 10.1053/j.gastro.2009.12.066. PMID: 20420948
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article
Sessile serrated adenoma: a brief history and current status.
Torlakovic E, Snover DC
Crit Rev Oncog 2006 Jul;12(1-2):27-39. doi: 10.1615/critrevoncog.v12.i1-2.30. PMID: 17078205

Therapy

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
SMAD4 juvenile polyposis syndrome and hereditary haemorrhagic telangiectasia presenting in a middle-aged man as a large fungating gastric mass, polyposis in both upper and lower GI tract and iron deficiency anaemia, with no known family history.
Chang W, Renaut P, Pretorius C
BMJ Case Rep 2020 Dec 22;13(12) doi: 10.1136/bcr-2020-236855. PMID: 33370972Free PMC Article
Yield of screening colonoscopy in first-degree relatives of patients with serrated polyposis syndrome.
Hazewinkel Y, Koornstra JJ, Boparai KS, van Os TA, Tytgat KM, Van Eeden S, Fockens P, Dekker E
J Clin Gastroenterol 2015 May-Jun;49(5):407-12. doi: 10.1097/MCG.0000000000000103. PMID: 24583756
Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.
Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T
Cancer Res 1999 Jul 15;59(14):3379-86. PMID: 10416598
Juvenile polyposis--a precancerous condition.
Jass JR, Williams CB, Bussey HJ, Morson BC
Histopathology 1988 Dec;13(6):619-30. doi: 10.1111/j.1365-2559.1988.tb02093.x. PMID: 2853131

Prognosis

Unusual colon polyps. Diagnosis: Cap polyposis.
da Cunha Araújo RN, Castanheira A, Silva A
Gastroenterology 2011 Oct;141(4):e1-2. Epub 2011 Aug 29 doi: 10.1053/j.gastro.2010.07.066. PMID: 21878333
Role of the serrated pathway in colorectal cancer pathogenesis.
Leggett B, Whitehall V
Gastroenterology 2010 Jun;138(6):2088-100. doi: 10.1053/j.gastro.2009.12.066. PMID: 20420948
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519
Does colonoscopic polypectomy reduce the incidence of colorectal carcinoma?
Meagher AP, Stuart M
Aust N Z J Surg 1994 Jun;64(6):400-4. doi: 10.1111/j.1445-2197.1994.tb02238.x. PMID: 8010901
The biology of colorectal carcinoma.
Jessup JM, Gallick GE
Curr Probl Cancer 1992 Sep-Oct;16(5):261-328. PMID: 1337732

Clinical prediction guides

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Yield of screening colonoscopy in first-degree relatives of patients with serrated polyposis syndrome.
Hazewinkel Y, Koornstra JJ, Boparai KS, van Os TA, Tytgat KM, Van Eeden S, Fockens P, Dekker E
J Clin Gastroenterol 2015 May-Jun;49(5):407-12. doi: 10.1097/MCG.0000000000000103. PMID: 24583756
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Unusual colon polyps. Diagnosis: Cap polyposis.
da Cunha Araújo RN, Castanheira A, Silva A
Gastroenterology 2011 Oct;141(4):e1-2. Epub 2011 Aug 29 doi: 10.1053/j.gastro.2010.07.066. PMID: 21878333
Does colonoscopic polypectomy reduce the incidence of colorectal carcinoma?
Meagher AP, Stuart M
Aust N Z J Surg 1994 Jun;64(6):400-4. doi: 10.1111/j.1445-2197.1994.tb02238.x. PMID: 8010901

Recent systematic reviews

Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

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