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Atrial fibrillation, familial, 17(ATFB17)

MedGen UID:
861997
Concept ID:
C4013560
Finding
Synonym: ATFB17
 
Monarch Initiative: MONDO:0800345
OMIM®: 608256; 611819

Definition

Familial atrial fibrillation is an inherited abnormality of the heart's normal rhythm. Atrial fibrillation is characterized by episodes of uncoordinated electrical activity (fibrillation) in the heart's upper chambers (the atria), which cause a fast and irregular heartbeat. If untreated, this abnormal heart rhythm (arrhythmia) can lead to dizziness, chest pain, a sensation of fluttering or pounding in the chest (palpitations), shortness of breath, or fainting (syncope). Atrial fibrillation also increases the risk of stroke and sudden death. Complications of atrial fibrillation can occur at any age, although some people with this heart condition never experience any health problems associated with the disorder. [from MedlinePlus Genetics]

Professional guidelines

PubMed

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
J Am Coll Cardiol 2022 May 3;79(17):e263-e421. Epub 2022 Apr 1 doi: 10.1016/j.jacc.2021.12.012. PMID: 35379503
Mendelson SJ, Prabhakaran S
JAMA 2021 Mar 16;325(11):1088-1098. doi: 10.1001/jama.2020.26867. PMID: 33724327
Tafur A, Douketis J
Heart 2018 Sep;104(17):1461-1467. Epub 2017 Dec 7 doi: 10.1136/heartjnl-2016-310581. PMID: 29217632

Curated

UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

Recent clinical studies

Etiology

Wegner FK, Eckardt L
Trends Cardiovasc Med 2025 Jan;35(1):1-7. Epub 2024 Apr 10 doi: 10.1016/j.tcm.2024.04.001. PMID: 38608971
Liu Y, Liu C, Liu Q
Glob Heart 2022;17(1):22. Epub 2022 Mar 29 doi: 10.5334/gh.1107. PMID: 35586743Free PMC Article
Staerk L, Sherer JA, Ko D, Benjamin EJ, Helm RH
Circ Res 2017 Apr 28;120(9):1501-1517. doi: 10.1161/CIRCRESAHA.117.309732. PMID: 28450367Free PMC Article
Nurs Stand 2016 Jan 6;30(19):17. doi: 10.7748/ns.30.19.17.s17. PMID: 26938394
Akrawinthawong K, Venkatesh Prasad K, Mehdirad AA, Ferreira SW
Curr Cardiol Rep 2015 Dec;17(12):118. doi: 10.1007/s11886-015-0674-9. PMID: 26482761

Diagnosis

Wegner FK, Eckardt L
Trends Cardiovasc Med 2025 Jan;35(1):1-7. Epub 2024 Apr 10 doi: 10.1016/j.tcm.2024.04.001. PMID: 38608971
Liu Y, Liu C, Liu Q
Glob Heart 2022;17(1):22. Epub 2022 Mar 29 doi: 10.5334/gh.1107. PMID: 35586743Free PMC Article
Lador A, Valderrábano M
Methodist Debakey Cardiovasc J 2021 Apr 5;17(1):52-55. Epub 2021 Mar 25 doi: 10.14797/ZQME8581. PMID: 34104321Free PMC Article
Tavares L, Lador A, Valderrábano M
Methodist Debakey Cardiovasc J 2021 Apr 5;17(1):49-52. Epub 2021 Mar 25 doi: 10.14797/ZYUT2951. PMID: 34104320Free PMC Article
Kim IC
Heart Fail Clin 2021 Jul;17(3):377-386. doi: 10.1016/j.hfc.2021.03.001. PMID: 34051970

Therapy

McIntyre WF, Benz AP, Becher N, Healey JS, Granger CB, Rivard L, Camm AJ, Goette A, Zapf A, Alings M, Connolly SJ, Kirchhof P, Lopes RD
Circulation 2024 Mar 26;149(13):981-988. Epub 2023 Nov 12 doi: 10.1161/CIRCULATIONAHA.123.067512. PMID: 37952187
Al-Kaisey AM, Parameswaran R, Bryant C, Anderson RD, Hawson J, Chieng D, Segan L, Voskoboinik A, Sugumar H, Wong GR, Finch S, Joseph SA, McLellan A, Ling LH, Morton J, Sparks P, Sanders P, Lee G, Kistler PM, Kalman JM
JAMA 2023 Sep 12;330(10):925-933. doi: 10.1001/jama.2023.14685. PMID: 37698564Free PMC Article
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Oldgren J, Åsberg S, Hijazi Z, Wester P, Bertilsson M, Norrving B; National TIMING Collaborators
Circulation 2022 Oct 4;146(14):1056-1066. Epub 2022 Sep 6 doi: 10.1161/CIRCULATIONAHA.122.060666. PMID: 36065821Free PMC Article
López-López JA, Sterne JAC, Thom HHZ, Higgins JPT, Hingorani AD, Okoli GN, Davies PA, Bodalia PN, Bryden PA, Welton NJ, Hollingworth W, Caldwell DM, Savović J, Dias S, Salisbury C, Eaton D, Stephens-Boal A, Sofat R
BMJ 2017 Nov 28;359:j5058. doi: 10.1136/bmj.j5058. PMID: 29183961Free PMC Article

Prognosis

Allam S, Hajduczok A, Sommer P, Mehta N
Card Electrophysiol Clin 2025 Mar;17(1):99-107. Epub 2024 Dec 18 doi: 10.1016/j.ccep.2024.10.002. PMID: 39893041
Lippi G, Sanchis-Gomar F, Cervellin G
Int J Stroke 2021 Feb;16(2):217-221. Epub 2020 Jan 19 doi: 10.1177/1747493019897870. PMID: 31955707
Cha MJ, Oh GC, Lee H, Park HE, Choi SY, Oh S
Heart Rhythm 2020 Dec;17(12):2086-2092. Epub 2020 Jul 14 doi: 10.1016/j.hrthm.2020.07.010. PMID: 32673797
Seitz J, Bars C, Théodore G, Beurtheret S, Lellouche N, Bremondy M, Ferracci A, Faure J, Penaranda G, Yamazaki M, Avula UM, Curel L, Siame S, Berenfeld O, Pisapia A, Kalifa J
J Am Coll Cardiol 2017 Jan 24;69(3):303-321. doi: 10.1016/j.jacc.2016.10.065. PMID: 28104073Free PMC Article
Marrouche NF, Wilber D, Hindricks G, Jais P, Akoum N, Marchlinski F, Kholmovski E, Burgon N, Hu N, Mont L, Deneke T, Duytschaever M, Neumann T, Mansour M, Mahnkopf C, Herweg B, Daoud E, Wissner E, Bansmann P, Brachmann J
JAMA 2014 Feb 5;311(5):498-506. doi: 10.1001/jama.2014.3. PMID: 24496537

Clinical prediction guides

Peng X, Li Y, Liu N, Xia S, Li X, Lai Y, He L, Sang C, Dong J, Ma C
Circ Arrhythm Electrophysiol 2024 Oct;17(10):e013037. Epub 2024 Oct 2 doi: 10.1161/CIRCEP.124.013037. PMID: 39355913
Al-Kaisey AM, Parameswaran R, Bryant C, Anderson RD, Hawson J, Chieng D, Segan L, Voskoboinik A, Sugumar H, Wong GR, Finch S, Joseph SA, McLellan A, Ling LH, Morton J, Sparks P, Sanders P, Lee G, Kistler PM, Kalman JM
JAMA 2023 Sep 12;330(10):925-933. doi: 10.1001/jama.2023.14685. PMID: 37698564Free PMC Article
Kim IC
Heart Fail Clin 2021 Jul;17(3):377-386. doi: 10.1016/j.hfc.2021.03.001. PMID: 34051970
John TJ, Muller W, Moses J
Heart 2020 Sep;106(17):1331-1368. doi: 10.1136/heartjnl-2020-316996. PMID: 32788290
Wange N, Anan I, Ericzon BG, Pennlert J, Pilebro B, Suhr OB, Wixner J
Transplantation 2018 Feb;102(2):e59-e66. doi: 10.1097/TP.0000000000001975. PMID: 29019809Free PMC Article

Recent systematic reviews

McIntyre WF, Benz AP, Becher N, Healey JS, Granger CB, Rivard L, Camm AJ, Goette A, Zapf A, Alings M, Connolly SJ, Kirchhof P, Lopes RD
Circulation 2024 Mar 26;149(13):981-988. Epub 2023 Nov 12 doi: 10.1161/CIRCULATIONAHA.123.067512. PMID: 37952187
Benali K, Khairy P, Hammache N, Petzl A, Da Costa A, Verma A, Andrade JG, Macle L
J Am Coll Cardiol 2023 May 30;81(21):2089-2099. doi: 10.1016/j.jacc.2023.03.418. PMID: 37225362
Cardoso R, Justino GB, Graffunder FP, Benevides L, Knijnik L, Sanchez LMF, d'Avila A
Arq Bras Cardiol 2022 Jul;119(1):87-94. doi: 10.36660/abc.20210477. PMID: 35830118Free PMC Article
Casula M, Andreis A, Avondo S, Vaira MP, Imazio M
Future Cardiol 2022 Aug;18(8):647-659. Epub 2022 Jul 5 doi: 10.2217/fca-2020-0206. PMID: 35787150
López-López JA, Sterne JAC, Thom HHZ, Higgins JPT, Hingorani AD, Okoli GN, Davies PA, Bodalia PN, Bryden PA, Welton NJ, Hollingworth W, Caldwell DM, Savović J, Dias S, Salisbury C, Eaton D, Stephens-Boal A, Sofat R
BMJ 2017 Nov 28;359:j5058. doi: 10.1136/bmj.j5058. PMID: 29183961Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

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