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Superoxide dismutase, elevated extracellular

MedGen UID:
855959
•Concept ID:
C3891298
•
Finding
Synonym: SUPEROXIDE DISMUTASE, ELEVATED EXTRACELLULAR
 
OMIM®: 185490

Professional guidelines

PubMed

Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC-133 through the inhibition of STAT/JAK signaling pathway.
Zhang Y, Zhu M, Krishna Mohan S, Hao Z
J Biochem Mol Toxicol 2021 Jan;35(1):e22608. Epub 2020 Sep 4 doi: 10.1002/jbt.22608. PMID: 32886819
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats.
Gong D, Lu J, Chen X, Choong SY, Zhang S, Chan YK, Glyn-Jones S, Gamble GD, Phillips AR, Cooper GJ
Mol Pharmacol 2006 Dec;70(6):2045-51. Epub 2006 Sep 14 doi: 10.1124/mol.106.028605. PMID: 16973718

Recent clinical studies

Etiology

Superoxide-anion triggers impairments of immune efficiency and stress response behaviors of Eisenia fetida earthworms.
Cruz Jung IED, Assmann CE, Mastella MH, Barbisan F, Spilliari Ruaro RA, Roggia I, Turra BO, Chitolina B, de Oliveira Alves A, Teixeira CF, Azzolin VF, Ribeiro EE, Medeiros Frescura Duarte MM, Mânica da Cruz IB
Chemosphere 2021 Apr;269:128712. Epub 2020 Oct 22 doi: 10.1016/j.chemosphere.2020.128712. PMID: 33189402
Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.
Rausch MP, Hastings KT
Mol Immunol 2015 Dec;68(2 Pt A):124-8. Epub 2015 Jun 23 doi: 10.1016/j.molimm.2015.06.008. PMID: 26116226Free PMC Article
Role of advanced glycation end products in cellular signaling.
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
Redox Biol 2014;2:411-29. Epub 2014 Jan 9 doi: 10.1016/j.redox.2013.12.016. PMID: 24624331Free PMC Article
Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging.
Levin ED
Curr Alzheimer Res 2005 Apr;2(2):191-6. doi: 10.2174/1567205053585710. PMID: 15974918
Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction.
Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF Jr, Loscalzo J
Clin Chem Lab Med 2003 Nov;41(11):1455-61. doi: 10.1515/CCLM.2003.223. PMID: 14656025

Diagnosis

Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways.
Akhter N, Wilson A, Arefanian H, Thomas R, Kochumon S, Al-Rashed F, Abu-Farha M, Al-Madhoun A, Al-Mulla F, Ahmad R, Sindhu S
Int J Mol Sci 2023 Oct 14;24(20) doi: 10.3390/ijms242015186. PMID: 37894865Free PMC Article
Identification of differentially expressed serum proteins in gastric adenocarcinoma.
Subbannayya Y, Mir SA, Renuse S, Manda SS, Pinto SM, Puttamallesh VN, Solanki HS, Manju HC, Syed N, Sharma R, Christopher R, Vijayakumar M, Veerendra Kumar KV, Keshava Prasad TS, Ramaswamy G, Kumar RV, Chatterjee A, Pandey A, Gowda H
J Proteomics 2015 Sep 8;127(Pt A):80-8. Epub 2015 May 5 doi: 10.1016/j.jprot.2015.04.021. PMID: 25952687Free PMC Article
Smoking and COPD increase sputum levels of extracellular superoxide dismutase.
Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL
Free Radic Biol Med 2011 Aug 1;51(3):726-32. Epub 2011 May 14 doi: 10.1016/j.freeradbiomed.2011.05.008. PMID: 21621610
Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.
Turner BJ, Atkin JD, Farg MA, Zang DW, Rembach A, Lopes EC, Patch JD, Hill AF, Cheema SS
J Neurosci 2005 Jan 5;25(1):108-17. doi: 10.1523/JNEUROSCI.4253-04.2005. PMID: 15634772Free PMC Article
Relationship between homocysteine and superoxide dismutase in homocystinuria: possible relevance to cardiovascular risk.
Wilcken DE, Wang XL, Adachi T, Hara H, Duarte N, Green K, Wilcken B
Arterioscler Thromb Vasc Biol 2000 May;20(5):1199-202. doi: 10.1161/01.atv.20.5.1199. PMID: 10807733

Therapy

Protective effect of astaxanthin on ANCA-associated vasculitis.
Sun RL, Shang JC, Han RH, Xing GQ
Int Immunopharmacol 2024 May 10;132:111928. Epub 2024 Mar 26 doi: 10.1016/j.intimp.2024.111928. PMID: 38537540
Interleukin-1β triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy.
Yamada M, Okutsu M
J Physiol 2023 Nov;601(21):4699-4721. Epub 2023 Oct 10 doi: 10.1113/JP285174. PMID: 37815420
Role of advanced glycation end products in cellular signaling.
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
Redox Biol 2014;2:411-29. Epub 2014 Jan 9 doi: 10.1016/j.redox.2013.12.016. PMID: 24624331Free PMC Article
Loss of extracellular superoxide dismutase induces severe IL-23-mediated skin inflammation in mice.
Lee YS, Cheon IS, Kim BH, Kwon MJ, Lee HW, Kim TY
J Invest Dermatol 2013 Mar;133(3):732-741. Epub 2012 Dec 6 doi: 10.1038/jid.2012.406. PMID: 23223134
Smoking and COPD increase sputum levels of extracellular superoxide dismutase.
Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL
Free Radic Biol Med 2011 Aug 1;51(3):726-32. Epub 2011 May 14 doi: 10.1016/j.freeradbiomed.2011.05.008. PMID: 21621610

Prognosis

Modulation of reactive oxygen species via ERK and STAT3 dependent signalling are involved in the response of mesothelioma cells to exemestane.
Nuvoli B, Camera E, Mastrofrancesco A, Briganti S, Galati R
Free Radic Biol Med 2018 Feb 1;115:266-277. Epub 2017 Dec 9 doi: 10.1016/j.freeradbiomed.2017.12.008. PMID: 29229551
Identification of differentially expressed serum proteins in gastric adenocarcinoma.
Subbannayya Y, Mir SA, Renuse S, Manda SS, Pinto SM, Puttamallesh VN, Solanki HS, Manju HC, Syed N, Sharma R, Christopher R, Vijayakumar M, Veerendra Kumar KV, Keshava Prasad TS, Ramaswamy G, Kumar RV, Chatterjee A, Pandey A, Gowda H
J Proteomics 2015 Sep 8;127(Pt A):80-8. Epub 2015 May 5 doi: 10.1016/j.jprot.2015.04.021. PMID: 25952687Free PMC Article
Decrease of reactive oxygen species-related biomarkers in the tissue-mimic 3D spheroid culture of human lung cells exposed to zinc oxide nanoparticles.
Kim E, Jeon WB, Kim S, Lee SK
J Nanosci Nanotechnol 2014 May;14(5):3356-65. doi: 10.1166/jnn.2014.8257. PMID: 24734552
Superoxide dismutase isoenzyme activities in plasma and tissues of Iraqi patients with breast cancer.
Hasan HR, Mathkor TH, Al-Habal MH
Asian Pac J Cancer Prev 2012;13(6):2571-6. doi: 10.7314/apjcp.2012.13.6.2571. PMID: 22938422
Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals.
Cooper GJ, Chan YK, Dissanayake AM, Leahy FE, Keogh GF, Frampton CM, Gamble GD, Brunton DH, Baker JR, Poppitt SD
Diabetes 2005 May;54(5):1468-76. doi: 10.2337/diabetes.54.5.1468. PMID: 15855335

Clinical prediction guides

Protective effect of astaxanthin on ANCA-associated vasculitis.
Sun RL, Shang JC, Han RH, Xing GQ
Int Immunopharmacol 2024 May 10;132:111928. Epub 2024 Mar 26 doi: 10.1016/j.intimp.2024.111928. PMID: 38537540
Salvianolic Acid A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Neutrophil NETosis.
Liu Q, Zhu CL, Li HR, Xie J, Guo Y, Li P, Zhao ZZ, Wang JF, Deng XM
Oxid Med Cell Longev 2022;2022:7411824. Epub 2022 Jul 21 doi: 10.1155/2022/7411824. PMID: 35910849Free PMC Article
Ca(2+)-activated mitochondrial biogenesis and functions improve stem cell fate in Rg3-treated human mesenchymal stem cells.
Hong T, Kim MY, Da Ly D, Park SJ, Eom YW, Park KS, Baik SK
Stem Cell Res Ther 2020 Nov 4;11(1):467. doi: 10.1186/s13287-020-01974-3. PMID: 33148318Free PMC Article
Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis.
Kamarajugadda S, Cai Q, Chen H, Nayak S, Zhu J, He M, Jin Y, Zhang Y, Ai L, Martin SS, Tan M, Lu J
Cell Death Dis 2013 Feb 21;4(2):e504. doi: 10.1038/cddis.2013.20. PMID: 23429290Free PMC Article
Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.
Sun ZW, Zhang L, Zhu SJ, Chen WC, Mei B
Neurosci Bull 2010 Feb;26(1):8-16. doi: 10.1007/s12264-010-0813-7. PMID: 20101268Free PMC Article

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