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Delayed sleep phase syndrome, susceptibility to(DSPD)

MedGen UID:
481621
•Concept ID:
C3279991
•
Finding
Synonym: DSPD
 
Gene (location): CRY1 (12q23.3)
 
Monarch Initiative: MONDO:0800001
OMIM®: 614163

Definition

Delayed sleep phase syndrome (DSPD) is a circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPD have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. Although psychosocial and environmental factors sometimes induce this kind of disorder, most patients with DSPD appear to have an abnormal circadian pacemaker and/or an abnormal entrainment system (summary by Hohjoh et al., 2003). [from OMIM]

Clinical features

From HPO
Sleep onset insomnia
MedGen UID:
98288
•Concept ID:
C0393760
•
Mental or Behavioral Dysfunction
Difficulty initiating sleep, that is, increased sleep onset latency, refers to the condition where it takes 30 minutes or more to fall asleep.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Current Considerations in the Diagnosis and Treatment of Circadian Rhythm Sleep-Wake Disorders in Children.
Witt RM, Byars KC, Decker K, Dye TJ, Riley JM, Simmons D, Smith DF
Semin Pediatr Neurol 2023 Dec;48:101091. Epub 2023 Oct 3 doi: 10.1016/j.spen.2023.101091. PMID: 38065634Free PMC Article
Suvorexant in the Treatment of Difficulty Falling and Staying Asleep (Insomnia).
Berger AA, Sottosanti ER, Winnick A, Keefe J, Gilbert E, Hasoon J, Thase ME, Kaye AD, Viswanath O, Urits I
Psychopharmacol Bull 2022 Feb 25;52(1):68-90. PMID: 35342199Free PMC Article
Evaluation and Management of Sleep and Circadian Rhythm Disturbance in Cancer.
Balachandran DD, Miller MA, Faiz SA, Yennurajalingam S, Innominato PF
Curr Treat Options Oncol 2021 Jul 2;22(9):81. doi: 10.1007/s11864-021-00872-x. PMID: 34213651

Recent clinical studies

Etiology

The sleep-circadian interface: A window into mental disorders.
Meyer N, Lok R, Schmidt C, Kyle SD, McClung CA, Cajochen C, Scheer FAJL, Jones MW, Chellappa SL
Proc Natl Acad Sci U S A 2024 Feb 27;121(9):e2214756121. Epub 2024 Feb 23 doi: 10.1073/pnas.2214756121. PMID: 38394243Free PMC Article
The Role of Circadian Rhythms and Sleep in Anorexia Nervosa.
Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.
Meléndez-Fernández OH, Liu JA, Nelson RJ
Int J Mol Sci 2023 Feb 8;24(4) doi: 10.3390/ijms24043392. PMID: 36834801Free PMC Article
Sleep, circadian system and traumatic stress.
Agorastos A, Olff M
Eur J Psychotraumatol 2021;12(1):1956746. Epub 2021 Sep 28 doi: 10.1080/20008198.2021.1956746. PMID: 34603634Free PMC Article
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Diagnosis

Advanced sleep phase syndrome: Role of genetics and aging.
Silvestri R, Guarnieri B
Handb Clin Neurol 2025;206:61-70. doi: 10.1016/B978-0-323-90918-1.00005-8. PMID: 39864932
The Role of Circadian Rhythms and Sleep in Anorexia Nervosa.
Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Sleep disorders in traumatic brain injury.
Paredes I, Navarro B, Lagares A
Neurocirugia (Astur : Engl Ed) 2021 Jul-Aug;32(4):178-187. Epub 2020 Dec 30 doi: 10.1016/j.neucie.2020.12.001. PMID: 34218878
Evaluation and Management of Sleep and Circadian Rhythm Disturbance in Cancer.
Balachandran DD, Miller MA, Faiz SA, Yennurajalingam S, Innominato PF
Curr Treat Options Oncol 2021 Jul 2;22(9):81. doi: 10.1007/s11864-021-00872-x. PMID: 34213651
Circadian Biology and Stroke.
Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM
Stroke 2021 Jun;52(6):2180-2190. Epub 2021 May 4 doi: 10.1161/STROKEAHA.120.031742. PMID: 33940951

Therapy

The Role of Circadian Rhythms and Sleep in Anorexia Nervosa.
Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Circadian Biology and Stroke.
Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM
Stroke 2021 Jun;52(6):2180-2190. Epub 2021 May 4 doi: 10.1161/STROKEAHA.120.031742. PMID: 33940951
Climate change and epilepsy: Insights from clinical and basic science studies.
Gulcebi MI, Bartolini E, Lee O, Lisgaras CP, Onat F, Mifsud J, Striano P, Vezzani A, Hildebrand MS, Jimenez-Jimenez D, Junck L, Lewis-Smith D, Scheffer IE, Thijs RD, Zuberi SM, Blenkinsop S, Fowler HJ, Foley A; Epilepsy Climate Change Consortium, Sisodiya SM
Epilepsy Behav 2021 Mar;116:107791. Epub 2021 Feb 10 doi: 10.1016/j.yebeh.2021.107791. PMID: 33578223Free PMC Article
Sleep- and circadian rhythm-associated pathways as therapeutic targets in bipolar disorder.
Bellivier F, Geoffroy PA, Etain B, Scott J
Expert Opin Ther Targets 2015 Jun;19(6):747-63. Epub 2015 Mar 2 doi: 10.1517/14728222.2015.1018822. PMID: 25726988
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Prognosis

Sleep, circadian system and traumatic stress.
Agorastos A, Olff M
Eur J Psychotraumatol 2021;12(1):1956746. Epub 2021 Sep 28 doi: 10.1080/20008198.2021.1956746. PMID: 34603634Free PMC Article
Climate change and epilepsy: Insights from clinical and basic science studies.
Gulcebi MI, Bartolini E, Lee O, Lisgaras CP, Onat F, Mifsud J, Striano P, Vezzani A, Hildebrand MS, Jimenez-Jimenez D, Junck L, Lewis-Smith D, Scheffer IE, Thijs RD, Zuberi SM, Blenkinsop S, Fowler HJ, Foley A; Epilepsy Climate Change Consortium, Sisodiya SM
Epilepsy Behav 2021 Mar;116:107791. Epub 2021 Feb 10 doi: 10.1016/j.yebeh.2021.107791. PMID: 33578223Free PMC Article
Circadian rhythm disruption and mental health.
Walker WH 2nd, Walton JC, DeVries AC, Nelson RJ
Transl Psychiatry 2020 Jan 23;10(1):28. doi: 10.1038/s41398-020-0694-0. PMID: 32066704Free PMC Article
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026
Performance impairment consequent to sleep loss: determinants of resistance and susceptibility.
King AC, Belenky G, Van Dongen HP
Curr Opin Pulm Med 2009 Nov;15(6):559-64. doi: 10.1097/MCP.0b013e3283319aad. PMID: 19713847

Clinical prediction guides

The sleep-circadian interface: A window into mental disorders.
Meyer N, Lok R, Schmidt C, Kyle SD, McClung CA, Cajochen C, Scheer FAJL, Jones MW, Chellappa SL
Proc Natl Acad Sci U S A 2024 Feb 27;121(9):e2214756121. Epub 2024 Feb 23 doi: 10.1073/pnas.2214756121. PMID: 38394243Free PMC Article
The Role of Circadian Rhythms and Sleep in Anorexia Nervosa.
Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Sleep, circadian system and traumatic stress.
Agorastos A, Olff M
Eur J Psychotraumatol 2021;12(1):1956746. Epub 2021 Sep 28 doi: 10.1080/20008198.2021.1956746. PMID: 34603634Free PMC Article
Circadian rhythm disruption and mental health.
Walker WH 2nd, Walton JC, DeVries AC, Nelson RJ
Transl Psychiatry 2020 Jan 23;10(1):28. doi: 10.1038/s41398-020-0694-0. PMID: 32066704Free PMC Article
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Recent systematic reviews

Shift work and migraine: A systematic review.
Leso V, Gervetti P, Mauro S, Macrini MC, Ercolano ML, Iavicoli I
J Occup Health 2020 Jan;62(1):e12116. doi: 10.1002/1348-9585.12116. PMID: 32515906Free PMC Article
Hypothesis: Folklore perpetuated expression of moon-associated bipolar disorders in anecdotally exaggerated werewolf guise.
Erren TC, Lewis P
Med Hypotheses 2019 Jan;122:129-133. Epub 2018 Nov 15 doi: 10.1016/j.mehy.2018.11.004. PMID: 30593396
CE: Original Research: Recognizing Delirium in Hospitalized Children: A Systematic Review of the Evidence on Risk Factors and Characteristics.
Holly C, Porter S, Echevarria M, Dreker M, Ruzehaji S
Am J Nurs 2018 Apr;118(4):24-36. doi: 10.1097/01.NAJ.0000532069.55339.f9. PMID: 29543606
Shift and night work and long working hours--a systematic review of safety implications.
Wagstaff AS, Sigstad Lie JA
Scand J Work Environ Health 2011 May;37(3):173-85. Epub 2011 Feb 3 doi: 10.5271/sjweh.3146. PMID: 21290083

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