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Recurrent spontaneous abortion

MedGen UID:
481069
•Concept ID:
C3279439
•
Finding; Pathologic Function
Synonym: Spontaneous abortion, recurrent
 
HPO: HP:0200067

Definition

Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent spontaneous abortion

Professional guidelines

PubMed

Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Immunotherapy for recurrent spontaneous abortion and its analogies to treatment for cancer.
Coulam CB, Faulk WP, McIntyre JA
Am J Reprod Immunol 1991 Apr;25(3):114-9. doi: 10.1111/j.1600-0897.1991.tb01077.x. PMID: 1930637
Treatment of recurrent spontaneous abortion.
Kilpatrick DC, Liston WA
Br Med J (Clin Res Ed) 1987 Sep 5;295(6598):607. doi: 10.1136/bmj.295.6598.607. PMID: 3117254Free PMC Article

Recent clinical studies

Etiology

Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.
He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Recent Advances in Treatment of Recurrent Spontaneous Abortion.
Deng T, Liao X, Zhu S
Obstet Gynecol Surv 2022 Jun;77(6):355-366. doi: 10.1097/OGX.0000000000001033. PMID: 35672876Free PMC Article
Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation.
Zhu D, Zou H, Liu J, Wang J, Ma C, Yin J, Peng X, Li D, Yang Y, Ren Y, Zhang Z, Zhou P, Wang X, Cao Y, Xu X
Front Immunol 2021;12:782792. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.782792. PMID: 35003098Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Recurrent spontaneous abortion.
Johnson CM, Kable WT
Nebr Med J 1995 Jun;80(6):136-9. PMID: 7623944

Diagnosis

Advances in post-translational modifications and recurrent spontaneous abortion.
Lai H, Yang Y, Zhang J
Gene 2024 Nov 15;927:148700. Epub 2024 Jun 14 doi: 10.1016/j.gene.2024.148700. PMID: 38880188
Coenzyme Q10 Stimulate Reproductive Vatality.
Nie X, Dong X, Hu Y, Xu F, Hu C, Shu C
Drug Des Devel Ther 2023;17:2623-2637. Epub 2023 Aug 30 doi: 10.2147/DDDT.S386974. PMID: 37667786Free PMC Article
Asherman's syndrome.
March CM
Semin Reprod Med 2011 Mar;29(2):83-94. Epub 2011 Mar 24 doi: 10.1055/s-0031-1272470. PMID: 21437822
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Recurrent spontaneous abortion.
Crosignani PG, Rubin BL
Hum Reprod 1991 Apr;6(4):609-10. doi: 10.1093/oxfordjournals.humrep.a137390. PMID: 1918317

Therapy

Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.
He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation.
Zhu D, Zou H, Liu J, Wang J, Ma C, Yin J, Peng X, Li D, Yang Y, Ren Y, Zhang Z, Zhou P, Wang X, Cao Y, Xu X
Front Immunol 2021;12:782792. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.782792. PMID: 35003098Free PMC Article
Asherman's syndrome.
March CM
Semin Reprod Med 2011 Mar;29(2):83-94. Epub 2011 Mar 24 doi: 10.1055/s-0031-1272470. PMID: 21437822
Trials and tribulation in the treatment of recurrent spontaneous abortion.
Clark DA, Daya S
Am J Reprod Immunol 1991 Jan;25(1):18-24. doi: 10.1111/j.1600-0897.1991.tb01058.x. PMID: 2029328
Immunotherapy for recurrent spontaneous abortion and its analogies to treatment for cancer.
Coulam CB, Faulk WP, McIntyre JA
Am J Reprod Immunol 1991 Apr;25(3):114-9. doi: 10.1111/j.1600-0897.1991.tb01077.x. PMID: 1930637

Prognosis

Advances in post-translational modifications and recurrent spontaneous abortion.
Lai H, Yang Y, Zhang J
Gene 2024 Nov 15;927:148700. Epub 2024 Jun 14 doi: 10.1016/j.gene.2024.148700. PMID: 38880188
Recent Advances in Treatment of Recurrent Spontaneous Abortion.
Deng T, Liao X, Zhu S
Obstet Gynecol Surv 2022 Jun;77(6):355-366. doi: 10.1097/OGX.0000000000001033. PMID: 35672876Free PMC Article
Predicting first-trimester outcome of embryos with cardiac activity in women with recurrent spontaneous abortion.
Li H, Qin S, Xiao F, Li Y, Gao Y, Zhang J, Xiao Q
J Int Med Res 2020 Jun;48(6):300060520911829. doi: 10.1177/0300060520911829. PMID: 32527173Free PMC Article
Preimplantation genetic diagnosis for aneuploidy screening in repeated implantation failure.
Caglar GS, Asimakopoulos B, Nikolettos N, Diedrich K, Al-Hasani S
Reprod Biomed Online 2005 Mar;10(3):381-8. doi: 10.1016/s1472-6483(10)61800-7. PMID: 15820047
Recurrent spontaneous abortion.
Poland BJ
Eur J Obstet Gynecol Reprod Biol 1984 Mar;16(6):369-75. doi: 10.1016/0028-2243(84)90017-0. PMID: 6734877

Clinical prediction guides

Compromised C3b-VSIG4 axis between decidual NK cells and macrophages contributes to recurrent spontaneous abortion.
Chen S, Zhang J, Chen J, Ke J, Huang Y, Du X, Fu B, Wei H
J Transl Med 2024 Nov 11;22(1):1017. doi: 10.1186/s12967-024-05829-w. PMID: 39529122Free PMC Article
Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.
He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Recent Advances in Treatment of Recurrent Spontaneous Abortion.
Deng T, Liao X, Zhu S
Obstet Gynecol Surv 2022 Jun;77(6):355-366. doi: 10.1097/OGX.0000000000001033. PMID: 35672876Free PMC Article
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nat Commun 2021 Jun 8;12(1):3428. doi: 10.1038/s41467-021-23827-0. PMID: 34103526Free PMC Article
Asymmetric antibodies and pregnancy.
Zenclussen AC, Gentile T, Kortebani G, Mazzolli A, Margni R
Am J Reprod Immunol 2001 May;45(5):289-94. doi: 10.1111/j.8755-8920.2001.450504.x. PMID: 11432403

Recent systematic reviews

Depression outcome in women with recurrent spontaneous abortion: A systematic review and meta-analysis.
Zhang Y, Feng M, Gao Y, Zhang M, Zhang Z
Eur J Obstet Gynecol Reprod Biol 2024 Sep;300:54-62. Epub 2024 Jul 1 doi: 10.1016/j.ejogrb.2024.06.044. PMID: 38986273
Exploring Gene-Diet Interactions for Mother-Child Health: A Systematic Review of Epidemiological Studies.
Favara G, Maugeri A, Magnano San Lio R, Barchitta M, Agodi A
Nutrients 2024 Mar 28;16(7) doi: 10.3390/nu16070994. PMID: 38613027Free PMC Article
Decidual macrophages in recurrent spontaneous abortion.
Zhao QY, Li QH, Fu YY, Ren CE, Jiang AF, Meng YH
Front Immunol 2022;13:994888. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.994888. PMID: 36569856Free PMC Article
Recurrent Spontaneous Abortion (RSA) and Maternal KIR Genes: A Comprehensive Meta-Analysis.
Akbari S, Shahsavar F, Karami R, Yari F, Anbari K, Ahmadi SAY
JBRA Assist Reprod 2020 May 1;24(2):197-213. doi: 10.5935/1518-0557.20190067. PMID: 32049474Free PMC Article
Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome.
Yang HL, Zhou WJ, Gu CJ, Meng YH, Shao J, Li DJ, Li MQ
Am J Reprod Immunol 2018 Jul;80(1):e12839. Epub 2018 Mar 1 doi: 10.1111/aji.12839. PMID: 29493042

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      Related medical variations
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      Related information in GTR
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      Clinical tests in GTR
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