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B lymphoblastic leukemia lymphoma with hyperdiploidy

MedGen UID:
397154
•Concept ID:
C2698311
•
Neoplastic Process
Synonyms: B Lymphoblastic Leukemia/Lymphoma with High Hyperdiploidy; B Lymphoblastic Leukemia/Lymphoma with Hyperdiploidy; B-Lymphoblastic Leukemia/Lymphoma with High Hyperdiploidy; B-Lymphoblastic Leukemia/Lymphoma with Hyperdiploidy; B-lymphoblastic leukemia/lymphoma with hyperdiploidy; Hyperdiploid B Lymphoblastic Leukemia/Lymphoma
SNOMED CT: B lymphoblastic leukemia lymphoma with hyperdiploidy (450953000); B lymphoblastic leukemia lymphoma with hyperdiploidy (838346000)
 
Monarch Initiative: MONDO:0035943
Orphanet: ORPHA585936

Definition

A precursor lymphoid neoplasm composed of B-lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It has a favorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • B lymphoblastic leukemia lymphoma with hyperdiploidy

Professional guidelines

PubMed

The Vitamin D Status in Children With Newly Diagnosed Acute Lymphoblastic Leukemia and Its Potential Impact on the Primary Symptoms of Leukemia and Course of Induction Treatment.
Malecka A, Hennig M, Jaworski R, Irga-Jaworska N
J Pediatr Hematol Oncol 2023 Jan 1;45(1):e4-e8. Epub 2022 Oct 19 doi: 10.1097/MPH.0000000000002579. PMID: 36598962
Treatment outcome of children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group (TCCSG) Study L04-16.
Takahashi H, Kajiwara R, Kato M, Hasegawa D, Tomizawa D, Noguchi Y, Koike K, Toyama D, Yabe H, Kajiwara M, Fujimura J, Sotomatsu M, Ota S, Maeda M, Goto H, Kato Y, Mori T, Inukai T, Shimada H, Fukushima K, Ogawa C, Makimoto A, Fukushima T, Ohki K, Koh K, Kiyokawa N, Manabe A, Ohara A
Int J Hematol 2018 Jul;108(1):98-108. Epub 2018 Mar 27 doi: 10.1007/s12185-018-2440-4. PMID: 29589281
Primary treatment of childhood acute lymphoblastic leukemia of non-T cell lineage (including infants).
Gaynon PS
Hematol Oncol Clin North Am 1990 Oct;4(5):915-36. PMID: 2262485

Recent clinical studies

Etiology

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL.
Bastian L, Beder T, Barz MJ, Bendig S, Bartsch L, Walter W, Wolgast N, Brändl B, Rohrandt C, Hansen BT, Hartmann AM, Iben K, Das Gupta D, Denker M, Zimmermann J, Wittig M, Chitadze G, Neumann M, Schneller F, Fiedler W, Steffen B, Stelljes M, Faul C, Schwartz S, Müller FJ, Cario G, Harder L, Haferlach C, Pfeifer H, Gökbuget N, Brüggemann M, Baldus CD
Blood 2024 Apr 4;143(14):1391-1398. doi: 10.1182/blood.2023021752. PMID: 38153913Free PMC Article
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia.
Teachey DT, Pui CH
Lancet Oncol 2019 Mar;20(3):e142-e154. doi: 10.1016/S1470-2045(19)30031-2. PMID: 30842058Free PMC Article
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.
Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY
Proc Natl Acad Sci U S A 2018 Dec 11;115(50):E11711-E11720. Epub 2018 Nov 28 doi: 10.1073/pnas.1814397115. PMID: 30487223Free PMC Article

Diagnosis

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL.
Bastian L, Beder T, Barz MJ, Bendig S, Bartsch L, Walter W, Wolgast N, Brändl B, Rohrandt C, Hansen BT, Hartmann AM, Iben K, Das Gupta D, Denker M, Zimmermann J, Wittig M, Chitadze G, Neumann M, Schneller F, Fiedler W, Steffen B, Stelljes M, Faul C, Schwartz S, Müller FJ, Cario G, Harder L, Haferlach C, Pfeifer H, Gökbuget N, Brüggemann M, Baldus CD
Blood 2024 Apr 4;143(14):1391-1398. doi: 10.1182/blood.2023021752. PMID: 38153913Free PMC Article
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
NUP98 rearrangement in B lymphoblastic leukemia with hyperdiploidy.
Liu H
Blood 2020 Aug 20;136(8):1011. doi: 10.1182/blood.2020006652. PMID: 32818249
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.
Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY
Proc Natl Acad Sci U S A 2018 Dec 11;115(50):E11711-E11720. Epub 2018 Nov 28 doi: 10.1073/pnas.1814397115. PMID: 30487223Free PMC Article

Therapy

Prognostic and Pharmacotypic Heterogeneity of Hyperdiploidy in Childhood ALL.
Lee SHR, Ashcraft E, Yang W, Roberts KG, Gocho Y, Rowland L, Inaba H, Karol SE, Jeha S, Crews KR, Mullighan CG, Relling MV, Evans WE, Cheng C, Yang JJ, Pui CH
J Clin Oncol 2023 Dec 10;41(35):5422-5432. Epub 2023 Sep 20 doi: 10.1200/JCO.23.00880. PMID: 37729596Free PMC Article
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia.
Teachey DT, Pui CH
Lancet Oncol 2019 Mar;20(3):e142-e154. doi: 10.1016/S1470-2045(19)30031-2. PMID: 30842058Free PMC Article
Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan.
Yen HJ, Chen SH, Chang TY, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, Hsiao CC, Chang TT, Chang TK, Peng CT, Lin MT, Jaing TH, Liu HC, Jou ST, Lu MY, Cheng CN, Sheen JM, Chiou SS, Hung GY, Wu KH, Yeh TC, Wang SC, Chen RL, Chang HH, Yang YL, Chen SH, Cheng SN, Chang YH, Chen BW, Hsieh YL, Huang FL, Ho WL, Wang JL, Chang CY, Chao YH, Lin PC, Chen YC, Liao YM, Lin TH, Shih LY, Liang DC
Pediatr Blood Cancer 2017 Oct;64(10) Epub 2017 Apr 24 doi: 10.1002/pbc.26557. PMID: 28436581
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article

Prognosis

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL.
Bastian L, Beder T, Barz MJ, Bendig S, Bartsch L, Walter W, Wolgast N, Brändl B, Rohrandt C, Hansen BT, Hartmann AM, Iben K, Das Gupta D, Denker M, Zimmermann J, Wittig M, Chitadze G, Neumann M, Schneller F, Fiedler W, Steffen B, Stelljes M, Faul C, Schwartz S, Müller FJ, Cario G, Harder L, Haferlach C, Pfeifer H, Gökbuget N, Brüggemann M, Baldus CD
Blood 2024 Apr 4;143(14):1391-1398. doi: 10.1182/blood.2023021752. PMID: 38153913Free PMC Article
Prognostic and Pharmacotypic Heterogeneity of Hyperdiploidy in Childhood ALL.
Lee SHR, Ashcraft E, Yang W, Roberts KG, Gocho Y, Rowland L, Inaba H, Karol SE, Jeha S, Crews KR, Mullighan CG, Relling MV, Evans WE, Cheng C, Yang JJ, Pui CH
J Clin Oncol 2023 Dec 10;41(35):5422-5432. Epub 2023 Sep 20 doi: 10.1200/JCO.23.00880. PMID: 37729596Free PMC Article
Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.
Panuciak K, Nowicka E, Mastalerczyk A, Zawitkowska J, Niedźwiecki M, Lejman M
Int J Mol Sci 2023 May 15;24(10) doi: 10.3390/ijms24108764. PMID: 37240110Free PMC Article
Is hyperdiploidy a favorable cytogenetics in adults with B-lymphoblastic leukemia?
Chen Z, Sun Y, Xie W, Wang SA, Hu S, Li S, Tang Z, Toruner G, Medeiros LJ, Tang G
Cancer Med 2019 Aug;8(9):4093-4099. Epub 2019 Jun 7 doi: 10.1002/cam4.2255. PMID: 31173486Free PMC Article
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.
Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY
Proc Natl Acad Sci U S A 2018 Dec 11;115(50):E11711-E11720. Epub 2018 Nov 28 doi: 10.1073/pnas.1814397115. PMID: 30487223Free PMC Article

Clinical prediction guides

Cytogenetic abnormalities and TP53 and RAS gene profiles of childhood acute lymphoblastic leukemia in Morocco.
Skhoun H, El Fessikh M, El Alaoui Al Abdallaoui M, Khattab M, Belkhayat A, Chebihi ZT, Hassani A, Abilkassem R, Agadr A, Dakka N, El Baghdadi J
Arch Pediatr 2024 May;31(4):238-244. Epub 2024 Apr 28 doi: 10.1016/j.arcped.2023.11.003. PMID: 38679547
Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL.
Bastian L, Beder T, Barz MJ, Bendig S, Bartsch L, Walter W, Wolgast N, Brändl B, Rohrandt C, Hansen BT, Hartmann AM, Iben K, Das Gupta D, Denker M, Zimmermann J, Wittig M, Chitadze G, Neumann M, Schneller F, Fiedler W, Steffen B, Stelljes M, Faul C, Schwartz S, Müller FJ, Cario G, Harder L, Haferlach C, Pfeifer H, Gökbuget N, Brüggemann M, Baldus CD
Blood 2024 Apr 4;143(14):1391-1398. doi: 10.1182/blood.2023021752. PMID: 38153913Free PMC Article
Cytogenetic Profile Of Acute Lymphoblastic Leukaemia Patients And Its Association With Induction Remission Status.
Niaz H, Malik HS, Mahmood R, Mehmood A, Nisar U, Jalil S
J Ayub Med Coll Abbottabad 2022 Oct-Dec;34(Suppl 1)(4):S909-S912. doi: 10.55519/JAMC-04-S4-10449. PMID: 36550642
Clinicopathologic and prognostic features of TdT-negative pediatric B-lymphoblastic leukemia.
Klairmont MM, Zhou Y, Cheng C, Pui CH, Jeha S, Gruber TA, Liu Y, Inaba H, Choi JK
Mod Pathol 2021 Nov;34(11):2050-2054. Epub 2021 Jun 19 doi: 10.1038/s41379-021-00853-3. PMID: 34148065Free PMC Article
New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia.
Moorman AV
Haematologica 2016 Apr;101(4):407-16. doi: 10.3324/haematol.2015.141101. PMID: 27033238Free PMC Article

Recent systematic reviews

lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review.
Illarregi U, Telleria J, Bilbao-Aldaiturriaga N, Lopez-Lopez E, Ballesteros J, Martin-Guerrero I, Gutierrez-Camino A
Int J Oncol 2022 May;60(5) Epub 2022 Apr 8 doi: 10.3892/ijo.2022.5348. PMID: 35419612

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