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Microvascular complications of diabetes, susceptibility to, 2(MVCD2)

MedGen UID:
436442
•Concept ID:
C2675471
•
Finding
Synonym: Microvascular complications of diabetes 2
 
Gene (location): EPO (7q22.1)
 
Monarch Initiative: MONDO:0012962
OMIM®: 612623

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the EPO gene. [from MONDO]

Professional guidelines

PubMed

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment.
Gurung RL, FitzGerald LM, McComish BJ, Verma N, Burdon KP
J Diabetes Res 2020;2020:5016916. Epub 2020 Nov 12 doi: 10.1155/2020/5016916. PMID: 33274237Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294

Recent clinical studies

Etiology

Association of metabolic syndrome and chronic kidney disease.
Scurt FG, Ganz MJ, Herzog C, Bose K, Mertens PR, Chatzikyrkou C
Obes Rev 2024 Jan;25(1):e13649. Epub 2023 Oct 2 doi: 10.1111/obr.13649. PMID: 37783465
Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Risk factors for type 2 diabetes mellitus.
Fletcher B, Gulanick M, Lamendola C
J Cardiovasc Nurs 2002 Jan;16(2):17-23. doi: 10.1097/00005082-200201000-00003. PMID: 11800065

Diagnosis

Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article
NIDDM--the devastating disease.
Horton ES
Diabetes Res Clin Pract 1995 Aug;28 Suppl:S3-11. doi: 10.1016/0168-8227(95)01087-t. PMID: 8529517

Therapy

Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study.
Li Y, Miao Y, Feng Q, Zhu W, Chen Y, Kang Q, Wang Z, Lu F, Zhang Q
Front Endocrinol (Lausanne) 2024;15:1401531. Epub 2024 Aug 30 doi: 10.3389/fendo.2024.1401531. PMID: 39280009Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Diabetes as a risk factor for medication-related osteonecrosis of the jaw.
Peer A, Khamaisi M
J Dent Res 2015 Feb;94(2):252-60. Epub 2014 Dec 4 doi: 10.1177/0022034514560768. PMID: 25477311Free PMC Article

Prognosis

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Cytokines in diabetic nephropathy.
Wu CC, Sytwu HK, Lin YF
Adv Clin Chem 2012;56:55-74. doi: 10.1016/b978-0-12-394317-0.00014-5. PMID: 22397028
NIDDM--the devastating disease.
Horton ES
Diabetes Res Clin Pract 1995 Aug;28 Suppl:S3-11. doi: 10.1016/0168-8227(95)01087-t. PMID: 8529517

Clinical prediction guides

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Cytokines in diabetic nephropathy.
Wu CC, Sytwu HK, Lin YF
Adv Clin Chem 2012;56:55-74. doi: 10.1016/b978-0-12-394317-0.00014-5. PMID: 22397028
NIDDM--the devastating disease.
Horton ES
Diabetes Res Clin Pract 1995 Aug;28 Suppl:S3-11. doi: 10.1016/0168-8227(95)01087-t. PMID: 8529517

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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    Related information

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      Clinical tests in GTR
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    • OMIM(Genes)
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