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Microvascular complications of diabetes, susceptibility to, 6(MVCD6)

MedGen UID:
382533
•Concept ID:
C2675128
•
Finding
Synonym: Microvascular complications of diabetes 6
 
Gene (location): SOD2 (6q25.3)
 
Monarch Initiative: MONDO:0012970
OMIM®: 612634

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the SOD2 gene. [from MONDO]

Professional guidelines

PubMed

Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Evaluation of submandibular and parotid salivary glands by ultrasonography in patients with diabetes.
Ozturk EMA, Yalcin ED
J Oral Rehabil 2024 Jul;51(7):1144-1157. Epub 2024 Mar 21 doi: 10.1111/joor.13685. PMID: 38514822
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus.
Cui J, Zhang X, Guo C, Zhang L
Biosci Rep 2020 Oct 30;40(10) doi: 10.1042/BSR20201105. PMID: 33016995Free PMC Article

Diagnosis

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus.
Cui J, Zhang X, Guo C, Zhang L
Biosci Rep 2020 Oct 30;40(10) doi: 10.1042/BSR20201105. PMID: 33016995Free PMC Article
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article

Therapy

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Effects of intensive insulin therapy on the retinal microvasculature in patients with type 2 diabetes mellitus: a prospective observational study.
Yang N, Li MX, Peng XY
BMC Ophthalmol 2022 Apr 22;22(1):187. doi: 10.1186/s12886-022-02397-9. PMID: 35459162Free PMC Article
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804
The role of inflammatory cytokines in diabetic nephropathy.
Navarro-González JF, Mora-Fernández C
J Am Soc Nephrol 2008 Mar;19(3):433-42. Epub 2008 Feb 6 doi: 10.1681/ASN.2007091048. PMID: 18256353

Prognosis

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article
Type II diabetes and its complications in Mexican Americans.
Stern MP, Haffner SM
Diabetes Metab Rev 1990 Feb;6(1):29-45. doi: 10.1002/dmr.5610060102. PMID: 2192854

Clinical prediction guides

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Evaluation of submandibular and parotid salivary glands by ultrasonography in patients with diabetes.
Ozturk EMA, Yalcin ED
J Oral Rehabil 2024 Jul;51(7):1144-1157. Epub 2024 Mar 21 doi: 10.1111/joor.13685. PMID: 38514822
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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