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Microvascular complications of diabetes, susceptibility to, 7(MVCD7)

MedGen UID:
382123
•Concept ID:
C2673520
•
Finding
Synonym: Microvascular complications of diabetes 7
 
Monarch Initiative: MONDO:0012971
OMIM®: 612635

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the HFE gene. [from MONDO]

Professional guidelines

PubMed

Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Evaluation of submandibular and parotid salivary glands by ultrasonography in patients with diabetes.
Ozturk EMA, Yalcin ED
J Oral Rehabil 2024 Jul;51(7):1144-1157. Epub 2024 Mar 21 doi: 10.1111/joor.13685. PMID: 38514822
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article

Diagnosis

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article

Therapy

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Investigation of angiotensin-1 converting enzyme 2 gene (G8790A) polymorphism in patients of type 2 diabetes mellitus with diabetic nephropathy in Pakistani population.
Younas H, Ijaz T, Choudhry N
PLoS One 2022;17(2):e0264038. Epub 2022 Feb 17 doi: 10.1371/journal.pone.0264038. PMID: 35176079Free PMC Article
Changes in characteristics and management of Asian and Anglo-Celts with type 2 diabetes over a 15-year period in an urban Australian community: The Fremantle Diabetes Study.
Tan ED, Davis WA, Davis TM
J Diabetes 2016 Jan;8(1):139-47. Epub 2015 Mar 24 doi: 10.1111/1753-0407.12267. PMID: 25581285
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935

Prognosis

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes.
Słomiński B, Skrzypkowska M, Ryba-Stanisławowska M, Myśliwiec M, Trzonkowski P
J Mol Med (Berl) 2021 May;99(5):675-683. Epub 2021 Jan 25 doi: 10.1007/s00109-020-02035-1. PMID: 33495869Free PMC Article
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article

Clinical prediction guides

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Evaluation of submandibular and parotid salivary glands by ultrasonography in patients with diabetes.
Ozturk EMA, Yalcin ED
J Oral Rehabil 2024 Jul;51(7):1144-1157. Epub 2024 Mar 21 doi: 10.1111/joor.13685. PMID: 38514822
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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