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Joint hyperflexibility

MedGen UID:
349493
•Concept ID:
C1862377
•
Finding
Synonyms: Hypermobilities, Joint; Hypermobility, Joint; Joint Hypermobilities; Joint Hypermobility; Joint Laxities; Joint Laxity; Laxities, Joint; Laxity, Joint
SNOMED CT: Hypermobility of joint (788453008); Joint hypermobility (788453008)

Professional guidelines

PubMed

A Systematic Review of Clinical Practice Guidelines on the Diagnosis and Management of Various Shoulder Disorders.
Lowry V, Lavigne P, Zidarov D, Matifat E, Cormier AA, Desmeules F
Arch Phys Med Rehabil 2024 Feb;105(2):411-426. Epub 2023 Oct 11 doi: 10.1016/j.apmr.2023.09.022. PMID: 37832814
Ankle Sprain and Chronic Lateral Ankle Instability: Optimizing Conservative Treatment.
Dhillon MS, Patel S, Baburaj V
Foot Ankle Clin 2023 Jun;28(2):297-307. Epub 2023 Feb 26 doi: 10.1016/j.fcl.2022.12.006. PMID: 37137624
Clinical assessment of acute lateral ankle sprain injuries (ROAST): 2019 consensus statement and recommendations of the International Ankle Consortium.
Delahunt E, Bleakley CM, Bossard DS, Caulfield BM, Docherty CL, Doherty C, Fourchet F, Fong DT, Hertel J, Hiller CE, Kaminski TW, McKeon PO, Refshauge KM, Remus A, Verhagen E, Vicenzino BT, Wikstrom EA, Gribble PA
Br J Sports Med 2018 Oct;52(20):1304-1310. Epub 2018 Jun 9 doi: 10.1136/bjsports-2017-098885. PMID: 29886432

Recent clinical studies

Etiology

Joint Flexibility and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After Mononucleosis.
Poomkudy JT, Torres C, Jason LA, Fishbein J, Katz BZ
Clin Ther 2024 Mar;46(3):285-288. Epub 2024 Jan 18 doi: 10.1016/j.clinthera.2023.12.011. PMID: 38242746Free PMC Article
A prospective evaluation of undiagnosed joint hypermobility syndrome in patients with gastrointestinal symptoms.
Fikree A, Grahame R, Aktar R, Farmer AD, Hakim AJ, Morris JK, Knowles CH, Aziz Q
Clin Gastroenterol Hepatol 2014 Oct;12(10):1680-87.e2. Epub 2014 Jan 16 doi: 10.1016/j.cgh.2014.01.014. PMID: 24440216
Age changes in the flexibility of Down's syndrome children.
Parker AW, James B
J Ment Defic Res 1985 Sep;29 ( Pt 3):207-18. doi: 10.1111/j.1365-2788.1985.tb00330.x. PMID: 2933522

Diagnosis

Joint Flexibility and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After Mononucleosis.
Poomkudy JT, Torres C, Jason LA, Fishbein J, Katz BZ
Clin Ther 2024 Mar;46(3):285-288. Epub 2024 Jan 18 doi: 10.1016/j.clinthera.2023.12.011. PMID: 38242746Free PMC Article
Rare neurological manifestations in a Saudi Arabian patient with Ehlers-Danlos syndrome and a novel homozygous variant in the TNXB gene.
Al-Harbi TM, Al-Rammah H, Al-Zahrani N, Liu Y, Sleiman PMA, Dridi W, Hakonarson H
Am J Med Genet A 2022 Feb;188(2):618-623. Epub 2021 Oct 11 doi: 10.1002/ajmg.a.62539. PMID: 34636138
Subdural Hygroma in an Infant with Marfan's Syndrome.
Ballmann L, Scholl-Bürgi S, Karall T, Odri Komazec I, Karall D, Michel M
Neuropediatrics 2021 Dec;52(6):423-430. Epub 2021 Jul 7 doi: 10.1055/s-0041-1731801. PMID: 34233372
Expanding the phenotype spectrum associated with pathogenic variants in the COL2A1 and COL11A1 genes.
Čopíková J, Paděrová J, Románková V, Havlovicová M, Balaščáková M, Zelinová M, Vejvalková Š, Simandlová M, Štěpánková J, Hořínová V, Kantorová E, Křečková G, Pospíšilová J, Boday A, Meszarosová AU, Turnovec M, Votýpka P, Lišková P, Kremlíková Pourová R
Ann Hum Genet 2020 Sep;84(5):380-392. Epub 2020 May 19 doi: 10.1111/ahg.12386. PMID: 32427345
An overlapping phenotype of Osteogenesis imperfecta and Ehlers-Danlos syndrome due to a heterozygous mutation in COL1A1 and biallelic missense variants in TNXB identified by whole exome sequencing.
Mackenroth L, Fischer-Zirnsak B, Egerer J, Hecht J, Kallinich T, Stenzel W, Spors B, von Moers A, Mundlos S, Kornak U, Gerhold K, Horn D
Am J Med Genet A 2016 Apr;170A(4):1080-5. Epub 2016 Jan 22 doi: 10.1002/ajmg.a.37547. PMID: 26799614

Prognosis

Rare neurological manifestations in a Saudi Arabian patient with Ehlers-Danlos syndrome and a novel homozygous variant in the TNXB gene.
Al-Harbi TM, Al-Rammah H, Al-Zahrani N, Liu Y, Sleiman PMA, Dridi W, Hakonarson H
Am J Med Genet A 2022 Feb;188(2):618-623. Epub 2021 Oct 11 doi: 10.1002/ajmg.a.62539. PMID: 34636138

Clinical prediction guides

Joint Flexibility and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After Mononucleosis.
Poomkudy JT, Torres C, Jason LA, Fishbein J, Katz BZ
Clin Ther 2024 Mar;46(3):285-288. Epub 2024 Jan 18 doi: 10.1016/j.clinthera.2023.12.011. PMID: 38242746Free PMC Article
Rare neurological manifestations in a Saudi Arabian patient with Ehlers-Danlos syndrome and a novel homozygous variant in the TNXB gene.
Al-Harbi TM, Al-Rammah H, Al-Zahrani N, Liu Y, Sleiman PMA, Dridi W, Hakonarson H
Am J Med Genet A 2022 Feb;188(2):618-623. Epub 2021 Oct 11 doi: 10.1002/ajmg.a.62539. PMID: 34636138
Expanding the phenotype spectrum associated with pathogenic variants in the COL2A1 and COL11A1 genes.
Čopíková J, Paděrová J, Románková V, Havlovicová M, Balaščáková M, Zelinová M, Vejvalková Š, Simandlová M, Štěpánková J, Hořínová V, Kantorová E, Křečková G, Pospíšilová J, Boday A, Meszarosová AU, Turnovec M, Votýpka P, Lišková P, Kremlíková Pourová R
Ann Hum Genet 2020 Sep;84(5):380-392. Epub 2020 May 19 doi: 10.1111/ahg.12386. PMID: 32427345

Supplemental Content

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