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Nicotine, poor metabolism of

MedGen UID:
343828
•Concept ID:
C1852516
•
Finding
Synonym: NICOTINE, POOR METABOLISM OF
 
OMIM®: 122720

Professional guidelines

PubMed

Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.
Jones SK, Wolf BJ, Froeliger B, Wallace K, Carpenter MJ, Alberg AJ
Nicotine Tob Res 2022 Mar 26;24(5):633-642. doi: 10.1093/ntr/ntab175. PMID: 34478556Free PMC Article
Effect of genotype and methylation of CYP2D6 on smoking behaviour.
Tiili EM, Antikainen MS, Mitiushkina NV, Sukhovskaya OA, Imyanitov EN, Hirvonen AP
Pharmacogenet Genomics 2015 Nov;25(11):531-40. doi: 10.1097/FPC.0000000000000166. PMID: 26287939
Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.
Young JW, Geyer MA
Biochem Pharmacol 2013 Oct 15;86(8):1122-32. Epub 2013 Jul 12 doi: 10.1016/j.bcp.2013.06.031. PMID: 23856289Free PMC Article

Recent clinical studies

Etiology

Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.
Jones SK, Wolf BJ, Froeliger B, Wallace K, Carpenter MJ, Alberg AJ
Nicotine Tob Res 2022 Mar 26;24(5):633-642. doi: 10.1093/ntr/ntab175. PMID: 34478556Free PMC Article
The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19.
Sifat AE, Nozohouri S, Villalba H, Vaidya B, Abbruscato TJ
J Pharmacol Exp Ther 2020 Dec;375(3):498-509. Epub 2020 Oct 8 doi: 10.1124/jpet.120.000170. PMID: 33033170Free PMC Article
Genetically determined metabolism of nicotine and its clinical significance.
Delijewski M, Bartoń A, Delijewska P, Balwierz R, Jakubiak G, Kośmider L, Pawlas N
Acta Biochim Pol 2019 Oct 4;66(4):375-381. doi: 10.18388/abp.2019_2645. PMID: 31584787
Neighborhood Factors and Urinary Metabolites of Nicotine, Phthalates, and Dichlorobenzene.
Galvez MP, McGovern K, Teitelbaum SL, Windham G, Wolff MS
Pediatrics 2018 Jan;141(Suppl 1):S87-S95. doi: 10.1542/peds.2017-1026L. PMID: 29292309Free PMC Article
Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.
Murphy SE
Chem Res Toxicol 2017 Jan 17;30(1):410-419. Epub 2016 Nov 22 doi: 10.1021/acs.chemrestox.6b00387. PMID: 28092945Free PMC Article

Diagnosis

RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media.
Stabenau KA, Zimmermann MT, Mathison A, Zeighami A, Samuels TL, Chun RH, Papsin BC, McCormick ME, Johnston N, Kerschner JE
Laryngoscope 2021 Nov;131(11):2590-2597. Epub 2021 Apr 12 doi: 10.1002/lary.29551. PMID: 33844317
The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19.
Sifat AE, Nozohouri S, Villalba H, Vaidya B, Abbruscato TJ
J Pharmacol Exp Ther 2020 Dec;375(3):498-509. Epub 2020 Oct 8 doi: 10.1124/jpet.120.000170. PMID: 33033170Free PMC Article
Cognitive Effects of Nicotine: Recent Progress.
Valentine G, Sofuoglu M
Curr Neuropharmacol 2018;16(4):403-414. doi: 10.2174/1570159X15666171103152136. PMID: 29110618Free PMC Article
Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.
Chiou J, Su CY, Jan YH, Yang CJ, Huang MS, Yu YL, Hsiao M
Sci Rep 2017 Aug 29;7(1):9830. doi: 10.1038/s41598-017-10366-2. PMID: 28852126Free PMC Article
Epigenetic regulators governing cancer stem cells and epithelial-mesenchymal transition in oral squamous cell carcinoma.
Patel S, Shah K, Mirza S, Daga A, Rawal R
Curr Stem Cell Res Ther 2015;10(2):140-52. doi: 10.2174/1574888x09666141020163700. PMID: 25330402

Therapy

Secondhand Nicotine Absorption From E-Cigarette Vapor vs Tobacco Smoke in Children.
Tattan-Birch H, Brown J, Jackson SE, Jarvis MJ, Shahab L
JAMA Netw Open 2024 Jul 1;7(7):e2421246. doi: 10.1001/jamanetworkopen.2024.21246. PMID: 38990571Free PMC Article
Asthma and smoking: A review.
Kamga A, Rochefort-Morel C, Guen YL, Ouksel H, Pipet A, Leroyer C
Respir Med Res 2022 Nov;82:100916. Epub 2022 Jul 25 doi: 10.1016/j.resmer.2022.100916. PMID: 35901579
The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19.
Sifat AE, Nozohouri S, Villalba H, Vaidya B, Abbruscato TJ
J Pharmacol Exp Ther 2020 Dec;375(3):498-509. Epub 2020 Oct 8 doi: 10.1124/jpet.120.000170. PMID: 33033170Free PMC Article
Genetically determined metabolism of nicotine and its clinical significance.
Delijewski M, Bartoń A, Delijewska P, Balwierz R, Jakubiak G, Kośmider L, Pawlas N
Acta Biochim Pol 2019 Oct 4;66(4):375-381. doi: 10.18388/abp.2019_2645. PMID: 31584787
Cognitive Effects of Nicotine: Recent Progress.
Valentine G, Sofuoglu M
Curr Neuropharmacol 2018;16(4):403-414. doi: 10.2174/1570159X15666171103152136. PMID: 29110618Free PMC Article

Prognosis

Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.
Jones SK, Wolf BJ, Froeliger B, Wallace K, Carpenter MJ, Alberg AJ
Nicotine Tob Res 2022 Mar 26;24(5):633-642. doi: 10.1093/ntr/ntab175. PMID: 34478556Free PMC Article
The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19.
Sifat AE, Nozohouri S, Villalba H, Vaidya B, Abbruscato TJ
J Pharmacol Exp Ther 2020 Dec;375(3):498-509. Epub 2020 Oct 8 doi: 10.1124/jpet.120.000170. PMID: 33033170Free PMC Article
Genetically determined metabolism of nicotine and its clinical significance.
Delijewski M, Bartoń A, Delijewska P, Balwierz R, Jakubiak G, Kośmider L, Pawlas N
Acta Biochim Pol 2019 Oct 4;66(4):375-381. doi: 10.18388/abp.2019_2645. PMID: 31584787
Cognitive Effects of Nicotine: Recent Progress.
Valentine G, Sofuoglu M
Curr Neuropharmacol 2018;16(4):403-414. doi: 10.2174/1570159X15666171103152136. PMID: 29110618Free PMC Article
Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.
Murphy SE
Chem Res Toxicol 2017 Jan 17;30(1):410-419. Epub 2016 Nov 22 doi: 10.1021/acs.chemrestox.6b00387. PMID: 28092945Free PMC Article

Clinical prediction guides

Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.
Jones SK, Wolf BJ, Froeliger B, Wallace K, Carpenter MJ, Alberg AJ
Nicotine Tob Res 2022 Mar 26;24(5):633-642. doi: 10.1093/ntr/ntab175. PMID: 34478556Free PMC Article
Downregulation of CYP2E1 is associated with poor prognosis and tumor progression of gliomas.
Ye L, Xu Y, Wang L, Zhang C, Hu P, Tong S, Liu Z, Tian D
Cancer Med 2021 Nov;10(22):8100-8113. Epub 2021 Oct 6 doi: 10.1002/cam4.4320. PMID: 34612013Free PMC Article
Genetically determined metabolism of nicotine and its clinical significance.
Delijewski M, Bartoń A, Delijewska P, Balwierz R, Jakubiak G, Kośmider L, Pawlas N
Acta Biochim Pol 2019 Oct 4;66(4):375-381. doi: 10.18388/abp.2019_2645. PMID: 31584787
Cognitive Effects of Nicotine: Recent Progress.
Valentine G, Sofuoglu M
Curr Neuropharmacol 2018;16(4):403-414. doi: 10.2174/1570159X15666171103152136. PMID: 29110618Free PMC Article
Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6.
Murphy SE
Chem Res Toxicol 2017 Jan 17;30(1):410-419. Epub 2016 Nov 22 doi: 10.1021/acs.chemrestox.6b00387. PMID: 28092945Free PMC Article

Recent systematic reviews

Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.
Jones SK, Wolf BJ, Froeliger B, Wallace K, Carpenter MJ, Alberg AJ
Nicotine Tob Res 2022 Mar 26;24(5):633-642. doi: 10.1093/ntr/ntab175. PMID: 34478556Free PMC Article
Comparison of nicotine exposure during pregnancy when smoking and abstinent with nicotine replacement therapy: systematic review and meta-analysis.
Hickson C, Lewis S, Campbell KA, Cooper S, Berlin I, Claire R, Oncken C, Coleman-Haynes T, Coleman T
Addiction 2019 Mar;114(3):406-424. Epub 2018 Dec 11 doi: 10.1111/add.14473. PMID: 30315598Free PMC Article
Clinical interventions to reduce secondhand smoke exposure among pregnant women: a systematic review.
Tong VT, Dietz PM, Rolle IV, Kennedy SM, Thomas W, England LJ
Tob Control 2015 May;24(3):217-23. Epub 2014 Apr 30 doi: 10.1136/tobaccocontrol-2013-051200. PMID: 24789602Free PMC Article

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