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Refractory epilepsy

MedGen UID:
203330
Concept ID:
C1096063
Disease or Syndrome
Synonym: Intractable epilepsy

Definition

Epilepsy that is refractory to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Refractory epilepsy

Professional guidelines

PubMed

Shao P, Li H, Jiang J, Guan Y, Chen X, Wang Y
Neuroimmunomodulation 2023;30(1):167-183. Epub 2023 Jun 27 doi: 10.1159/000531626. PMID: 37369181Free PMC Article
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Sampaio LP
Arq Neuropsiquiatr 2016 Oct;74(10):842-848. doi: 10.1590/0004-282X20160116. PMID: 27759811

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Sourbron J, Klinkenberg S, van Kuijk SMJ, Lagae L, Lambrechts D, Braakman HMH, Majoie M
Childs Nerv Syst 2020 Jun;36(6):1099-1109. Epub 2020 Mar 16 doi: 10.1007/s00381-020-04578-7. PMID: 32173786
Lambrechts DA, de Kinderen RJ, Vles JS, de Louw AJ, Aldenkamp AP, Majoie HJ
Acta Neurol Scand 2017 Feb;135(2):231-239. Epub 2016 Mar 29 doi: 10.1111/ane.12592. PMID: 27027847
Abramovici S, Bagić A
Handb Clin Neurol 2016;138:159-71. doi: 10.1016/B978-0-12-802973-2.00010-0. PMID: 27637958
van der Louw E, van den Hurk D, Neal E, Leiendecker B, Fitzsimmon G, Dority L, Thompson L, Marchió M, Dudzińska M, Dressler A, Klepper J, Auvin S, Cross JH
Eur J Paediatr Neurol 2016 Nov;20(6):798-809. Epub 2016 Jul 17 doi: 10.1016/j.ejpn.2016.07.009. PMID: 27470655
Kutlu G, Erdal A, Gomceli YB, Inan LE
Neurosciences (Riyadh) 2013 Jul;18(3):284-6. PMID: 23887223

Diagnosis

Liang C, Chu E, Kuoy E, Soun JE
J Neuroimaging 2023 Jan;33(1):19-34. Epub 2022 Oct 10 doi: 10.1111/jon.13060. PMID: 36217010
Poyuran R
Indian J Pathol Microbiol 2022 May;65(Supplement):S176-S188. doi: 10.4103/ijpm.ijpm_1026_21. PMID: 35562148
Ali I, Houck K
Neurol Clin 2021 Aug;39(3):797-810. doi: 10.1016/j.ncl.2021.04.003. PMID: 34215387
Ravat SH, Jain V
J Indian Med Assoc 2010 Jul;108(7):418, 427-30. PMID: 21192500
Kwan P, Brodie MJ
N Engl J Med 2000 Feb 3;342(5):314-9. doi: 10.1056/NEJM200002033420503. PMID: 10660394

Therapy

Potschka H, Bhatti SFM, Tipold A, McGrath S
Vet J 2022 Dec;290:105913. Epub 2022 Oct 6 doi: 10.1016/j.tvjl.2022.105913. PMID: 36209995
Courties A, Berenbaum F, Sellam J
Joint Bone Spine 2021 May;88(3):105149. Epub 2021 Feb 3 doi: 10.1016/j.jbspin.2021.105149. PMID: 33548494
Sourbron J, Klinkenberg S, van Kuijk SMJ, Lagae L, Lambrechts D, Braakman HMH, Majoie M
Childs Nerv Syst 2020 Jun;36(6):1099-1109. Epub 2020 Mar 16 doi: 10.1007/s00381-020-04578-7. PMID: 32173786
Gaston TE, Szaflarski JP
Curr Neurol Neurosci Rep 2018 Sep 8;18(11):73. doi: 10.1007/s11910-018-0882-y. PMID: 30194563
Ravat SH, Jain V
J Indian Med Assoc 2010 Jul;108(7):418, 427-30. PMID: 21192500

Prognosis

Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482
Abramovici S, Bagić A
Handb Clin Neurol 2016;138:159-71. doi: 10.1016/B978-0-12-802973-2.00010-0. PMID: 27637958
Banerjee TK, Das SK
J Assoc Physicians India 2013 Aug;61(8 Suppl):52-4. PMID: 24818331
Ryvlin P, Nashef L, Lhatoo SD, Bateman LM, Bird J, Bleasel A, Boon P, Crespel A, Dworetzky BA, Høgenhaven H, Lerche H, Maillard L, Malter MP, Marchal C, Murthy JM, Nitsche M, Pataraia E, Rabben T, Rheims S, Sadzot B, Schulze-Bonhage A, Seyal M, So EL, Spitz M, Szucs A, Tan M, Tao JX, Tomson T
Lancet Neurol 2013 Oct;12(10):966-77. Epub 2013 Sep 4 doi: 10.1016/S1474-4422(13)70214-X. PMID: 24012372
Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N; SANTE Study Group
Epilepsia 2010 May;51(5):899-908. Epub 2010 Mar 17 doi: 10.1111/j.1528-1167.2010.02536.x. PMID: 20331461

Clinical prediction guides

Aicua-Rapun I, André P, Novy J
Curr Neuropharmacol 2019;17(5):447-458. doi: 10.2174/1570159X16666180308154646. PMID: 29521237Free PMC Article
Lambrechts DA, de Kinderen RJ, Vles JS, de Louw AJ, Aldenkamp AP, Majoie HJ
Acta Neurol Scand 2017 Feb;135(2):231-239. Epub 2016 Mar 29 doi: 10.1111/ane.12592. PMID: 27027847
Banerjee TK, Das SK
J Assoc Physicians India 2013 Aug;61(8 Suppl):52-4. PMID: 24818331
Noh HS, Kim YS, Choi WS
Epilepsia 2008 Nov;49 Suppl 8:120-3. doi: 10.1111/j.1528-1167.2008.01855.x. PMID: 19049608
Boon P, Moors I, De Herdt V, Vonck K
Seizure 2006 Jun;15(4):259-63. Epub 2006 May 2 doi: 10.1016/j.seizure.2006.02.014. PMID: 16651013

Recent systematic reviews

Devi N, Madaan P, Kandoth N, Bansal D, Sahu JK
JAMA Pediatr 2023 Mar 1;177(3):258-266. doi: 10.1001/jamapediatrics.2022.5648. PMID: 36716045Free PMC Article
Talwar A, Estes E, Aparasu R, Reddy DS
Exp Neurol 2023 Jan;359:114238. Epub 2022 Oct 4 doi: 10.1016/j.expneurol.2022.114238. PMID: 36206805
Zweers H, van Wegberg AMJ, Janssen MCH, Wortmann SB
Orphanet J Rare Dis 2021 Jul 3;16(1):295. doi: 10.1186/s13023-021-01927-w. PMID: 34217336Free PMC Article
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

    Consumer resources

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