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Abnormal platelet function

MedGen UID:
488944
•Concept ID:
C0855740
•
Finding
HPO: HP:0011869

Definition

Any anomaly in the function of thrombocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal platelet function

Professional guidelines

PubMed

An update on management of pediatric epistaxis.
Patel N, Maddalozzo J, Billings KR
Int J Pediatr Otorhinolaryngol 2014 Aug;78(8):1400-4. Epub 2014 Jun 16 doi: 10.1016/j.ijporl.2014.06.009. PMID: 24972938
Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management.
Furlan JC, Fehlings MG
Neurosurg Focus 2008;25(5):E13. doi: 10.3171/FOC.2008.25.11.E13. PMID: 18980473
Cardiac anesthesia risk management. Hemorrhage, coagulation, and transfusion: a risk-benefit analysis.
Spiess BD
J Cardiothorac Vasc Anesth 1994 Feb;8(1 Suppl 1):19-22. doi: 10.1016/1053-0770(94)90612-2. PMID: 8167299

Recent clinical studies

Etiology

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis.
Fan Z, Wang L, Jiang H, Lin Y, Wang Z
Dermatology 2021;237(1):56-65. Epub 2020 Apr 29 doi: 10.1159/000505536. PMID: 32349003
Flavonoids and Platelet-Derived Thrombotic Disorders.
Lopez JJ, El Haouari M, Jardin I, Alonso N, Regodon S, Diez-Bello R, Redondo PC, Rosado JA
Curr Med Chem 2019;26(39):7035-7047. doi: 10.2174/0929867325666180417170218. PMID: 29667548
Lipids and thrombosis.
Gasser JA, Betteridge DJ
Baillieres Clin Endocrinol Metab 1990 Dec;4(4):923-38. doi: 10.1016/s0950-351x(05)80085-0. PMID: 2082912
Increased von Willebrand factor in diabetes mellitus.
Lufkin EG, Fass DN, O'Fallon WM, Bowie EJ
Metabolism 1979 Jan;28(1):63-6. doi: 10.1016/0026-0495(79)90169-0. PMID: 310504
Platelet abnormalities in diabetic peripheral neuropathy.
O'Malley CB, Ward JD, Timperley WR, Porter NR, Preston FE
Lancet 1975 Dec 27;2(7948):1274-6. doi: 10.1016/s0140-6736(75)90610-8. PMID: 54797

Diagnosis

Jacobsen syndrome.
Mattina T, Perrotta CS, Grossfeld P
Orphanet J Rare Dis 2009 Mar 7;4:9. doi: 10.1186/1750-1172-4-9. PMID: 19267933Free PMC Article
von Willebrand disease.
Zimmerman TS, Ruggeri ZM
Hum Pathol 1987 Feb;18(2):140-52. doi: 10.1016/s0046-8177(87)80332-5. PMID: 3100416
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Schafer AI
N Engl J Med 1982 Feb 18;306(7):381-6. doi: 10.1056/NEJM198202183060701. PMID: 6799826
Sulfonylureas and platelet function.
Klaff LJ, Kernoff L, Vinik AI, Jackson WP, Jacobs P
Am J Med 1981 Mar;70(3):627-30. doi: 10.1016/0002-9343(81)90585-4. PMID: 6782875
Platelet abnormalities in diabetic peripheral neuropathy.
O'Malley CB, Ward JD, Timperley WR, Porter NR, Preston FE
Lancet 1975 Dec 27;2(7948):1274-6. doi: 10.1016/s0140-6736(75)90610-8. PMID: 54797

Therapy

von Willebrand disease.
Zimmerman TS, Ruggeri ZM
Hum Pathol 1987 Feb;18(2):140-52. doi: 10.1016/s0046-8177(87)80332-5. PMID: 3100416
Platelet adhesiveness to glass beads in liver disease.
Langley PG, Hughes RD, Williams R
Acta Haematol 1982;67(2):124-7. doi: 10.1159/000207038. PMID: 6801894
Sulfonylureas and platelet function.
Klaff LJ, Kernoff L, Vinik AI, Jackson WP, Jacobs P
Am J Med 1981 Mar;70(3):627-30. doi: 10.1016/0002-9343(81)90585-4. PMID: 6782875
Bleeding disorders due to abnormal platelet function.
Weiss HJ
Med Clin North Am 1973 Mar;57(2):517-30. doi: 10.1016/s0025-7125(16)32295-7. PMID: 4571801
Dozing and bruising due to abnormal platelet function (thrombocytopathia). A family study of the syndrome.
Zucker S, Mielke CH Jr, Durocher JR, Crosby WH
Ann Intern Med 1972 May;76(5):725-31. doi: 10.7326/0003-4819-76-5-725. PMID: 5025323

Prognosis

Correlation of Platelet Function with Postpartum Hemorrhage and Venous Thromboembolism in Patients with Gestational Hypertension Complicated with Diabetes.
Li N, Liu Y, Yun A, Song S
Comput Math Methods Med 2022;2022:2423333. Epub 2022 Jul 18 doi: 10.1155/2022/2423333. PMID: 35898483Free PMC Article
Screening for Platelet Dysfunction and Use of Prophylactic Tranexamic Acid in Patients Undergoing Deep Brain Stimulation: A Retrospective Analysis of Incidence and Outcome of Intracranial Hemorrhage.
Helmers AK, Kubelt C, Birkenfeld F, Deuschl G, Falk D, Mehdorn HM, Witt K, Nowak-Göttl U, Synowitz M, Paschen S
Stereotact Funct Neurosurg 2020;98(3):176-181. Epub 2020 Mar 30 doi: 10.1159/000505714. PMID: 32224614
Platelet Function Tests and Inflammatory Markers for the Differentiation of Primary Thrombocytosis and Secondary Thrombocytosis.
Kanya P, Rattarittamrong E, Wongtakan O, Rattanathammethee T, Chai-Adisaksopha C, Tantiworawit A, Norrasethada L
Asian Pac J Cancer Prev 2019 Jul 1;20(7):2079-2085. doi: 10.31557/APJCP.2019.20.7.2079. PMID: 31350969Free PMC Article
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753
Laboratory investigations and prediction of thrombotic risk in polycythemia vera.
Boneu B
Nouv Rev Fr Hematol (1978) 1994 Apr;36(2):183-5. PMID: 8036139

Clinical prediction guides

Correlation of Platelet Function with Postpartum Hemorrhage and Venous Thromboembolism in Patients with Gestational Hypertension Complicated with Diabetes.
Li N, Liu Y, Yun A, Song S
Comput Math Methods Med 2022;2022:2423333. Epub 2022 Jul 18 doi: 10.1155/2022/2423333. PMID: 35898483Free PMC Article
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753
From genetics to epigenetics in platelet research.
Freson K, Izzi B, Van Geet C
Thromb Res 2012 Mar;129(3):325-9. Epub 2011 Dec 20 doi: 10.1016/j.thromres.2011.11.050. PMID: 22192152
Platelet adhesiveness to glass beads in liver disease.
Langley PG, Hughes RD, Williams R
Acta Haematol 1982;67(2):124-7. doi: 10.1159/000207038. PMID: 6801894
Platelet function tests in disease.
Tschopp TB, Zucker MB
Annu Rev Med 1973;24:1-18. doi: 10.1146/annurev.me.24.020173.000245. PMID: 4575852

Recent systematic reviews

Screening for Platelet Dysfunction and Use of Prophylactic Tranexamic Acid in Patients Undergoing Deep Brain Stimulation: A Retrospective Analysis of Incidence and Outcome of Intracranial Hemorrhage.
Helmers AK, Kubelt C, Birkenfeld F, Deuschl G, Falk D, Mehdorn HM, Witt K, Nowak-Göttl U, Synowitz M, Paschen S
Stereotact Funct Neurosurg 2020;98(3):176-181. Epub 2020 Mar 30 doi: 10.1159/000505714. PMID: 32224614

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