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Trichomegaly(TCMGLY)

MedGen UID:
163139
•Concept ID:
C0854699
•
Finding
Synonym: TCMGLY
 
Gene (location): FGF5 (4q21.21)
 
Monarch Initiative: MONDO:0008593
OMIM®: 190330

Definition

Trichomegaly (TCMGLY), or excessively long eyelashes, is a rare familial trait (Higgins et al., 2014). [from OMIM]

Clinical features

From HPO
Long eyelashes
MedGen UID:
342955
•Concept ID:
C1853738
•
Finding
Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective).
See: Feature record | Search on this feature
Cataract
MedGen UID:
39462
•Concept ID:
C0086543
•
Disease or Syndrome
A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Skin Toxicities During Colorectal Cancer Chemotherapy: Incidence and Pearls of Treatment in Our Experience.
Panariello L, Donnarumma M, Iaffaioli RV, Chiodini P, Annunziata MC, Peduto T, Fabbrocini G
Clin Colorectal Cancer 2020 Dec;19(4):e235-e242. Epub 2020 May 29 doi: 10.1016/j.clcc.2020.05.006. PMID: 32665093
Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities.
Chu CY, Chen KY, Wen-Cheng Chang J, Wei YF, Lee CH, Wang WM
J Formos Med Assoc 2017 Jun;116(6):413-423. Epub 2017 Mar 27 doi: 10.1016/j.jfma.2017.03.001. PMID: 28351555
Ocular toxicities of epidermal growth factor receptor inhibitors and their management.
Basti S
Cancer Nurs 2007 Jul-Aug;30(4 Suppl 1):S10-6. doi: 10.1097/01.NCC.0000281759.23823.82. PMID: 17666986

Recent clinical studies

Etiology

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, Park A, Cardenas K, Mesinkovska NA
J Eur Acad Dermatol Venereol 2022 Apr;36(4):536-546. Epub 2021 Dec 31 doi: 10.1111/jdv.17877. PMID: 34919300
Trichomegaly induced by topical tacrolimus for the treatment of periorbital vitiligo: A brief report of a new adverse effect.
Molés-Poveda P, Cowen EW
Pediatr Dermatol 2019 Jul;36(4):e95-e96. Epub 2019 May 9 doi: 10.1111/pde.13825. PMID: 31070265
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Progressive trichomegaly.
Vano-Galvan S, Moreno-Martin P, Jaén P
Neth J Med 2009 Jan;67(1):35-6. PMID: 19155549
Congenital trichomegaly, pigmentary degeneration of the retina and growth retardation (Oliver-McFarlane syndrome): 28-year follow-up of the first reported case.
Chang TS, McFarlane DC, Oliver G, Willis NR
Can J Ophthalmol 1993 Jun;28(4):191-3. PMID: 8343920

Diagnosis

Pinnae and facial hypertrichosis induced by cetuximab.
Alexandris D, Alevizopoulos N, Palamaris K, Gakiopoulou C, Theocharis S
J Oncol Pharm Pract 2023 Apr;29(3):731-737. Epub 2022 Jul 12 doi: 10.1177/10781552221114073. PMID: 35821579
Trichomegaly induced by topical tacrolimus for the treatment of periorbital vitiligo: A brief report of a new adverse effect.
Molés-Poveda P, Cowen EW
Pediatr Dermatol 2019 Jul;36(4):e95-e96. Epub 2019 May 9 doi: 10.1111/pde.13825. PMID: 31070265
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Essential trichomegaly: case report.
Rossetto JD, Nascimento H, Muccioli C, Belfort R Jr
Arq Bras Oftalmol 2013 Jan-Feb;76(1):50-1. doi: 10.1590/s0004-27492013000100015. PMID: 23812530
Erlotinib-associated trichomegaly.
Lane K, Goldstein SM
Ophthalmic Plast Reconstr Surg 2007 Jan-Feb;23(1):65-6. doi: 10.1097/IOP.0b013e31802d9802. PMID: 17237698

Therapy

Trichomegaly and Trichiasis Associated with Pemigatinib.
Campagna GA, Liu ST, Tsui E
Ophthalmology 2021 Sep;128(9):1364. doi: 10.1016/j.ophtha.2021.02.022. PMID: 34420597
Panitumumab-induced trichomegaly.
Sütcüoğlu O, Özet A
Curr Probl Cancer 2021 Dec;45(6):100748. Epub 2021 Apr 23 doi: 10.1016/j.currproblcancer.2021.100748. PMID: 33933278
Hair disorders in patients with cancer.
Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME
J Am Acad Dermatol 2019 May;80(5):1179-1196. Epub 2018 Apr 14 doi: 10.1016/j.jaad.2018.03.055. PMID: 29660422Free PMC Article
Progressive trichomegaly.
Vano-Galvan S, Moreno-Martin P, Jaén P
Neth J Med 2009 Jan;67(1):35-6. PMID: 19155549
Erlotinib-associated trichomegaly.
Lane K, Goldstein SM
Ophthalmic Plast Reconstr Surg 2007 Jan-Feb;23(1):65-6. doi: 10.1097/IOP.0b013e31802d9802. PMID: 17237698

Prognosis

Trichomegaly Associated with Panitumumab.
Goyal A, Blaes A
N Engl J Med 2020 Oct 15;383(16):e94. doi: 10.1056/NEJMicm2003622. PMID: 33053288
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Congenital trichomegaly, pigmentary degeneration of the retina and growth retardation (Oliver-McFarlane syndrome): 28-year follow-up of the first reported case.
Chang TS, McFarlane DC, Oliver G, Willis NR
Can J Ophthalmol 1993 Jun;28(4):191-3. PMID: 8343920
Oliver McFarlane syndrome: a 25-year follow-up.
Sampson JR, Tolmie JL, Cant JS
Am J Med Genet 1989 Oct;34(2):199-201. doi: 10.1002/ajmg.1320340213. PMID: 2816997

Clinical prediction guides

Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Hair disorders associated with autoimmune connective tissue diseases.
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949
The cutaneous epidermal growth factor network: Can it be translated clinically to stimulate hair growth?
Alexandrescu DT, Kauffman CL, Dasanu CA
Dermatol Online J 2009 Mar 15;15(3):1. PMID: 19379645
Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of literature.
Zhang G, Basti S, Jampol LM
Cornea 2007 Aug;26(7):858-60. doi: 10.1097/ICO.0b013e318064584a. PMID: 17667622
Lash ptosis caused by latanoprost.
Casson RJ, Selva D
Am J Ophthalmol 2005 May;139(5):932-3. doi: 10.1016/j.ajo.2004.10.062. PMID: 15860312

Recent systematic reviews

Ophthalmologic and facial abnormalities of Nicolaides-Baraitser syndrome.
Simmers R, Goodwin A, Al Saif H, Couser N
Ophthalmic Genet 2022 Oct;43(5):699-702. Epub 2022 Jun 27 doi: 10.1080/13816810.2022.2089358. PMID: 35762114
Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, Park A, Cardenas K, Mesinkovska NA
J Eur Acad Dermatol Venereol 2022 Apr;36(4):536-546. Epub 2021 Dec 31 doi: 10.1111/jdv.17877. PMID: 34919300

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    • OMIM(Genes)
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