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Sudden unexplained death

MedGen UID:
636245
Concept ID:
C0520806
Finding
Synonyms: Sudden death, cause unknown; Unexplained sudden death
SNOMED CT: Unexplained sudden death (90049009); Sudden death, cause unknown (274644002)

Professional guidelines

PubMed

Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Stiles MK, Wilde AAM, Abrams DJ, Ackerman MJ, Albert CM, Behr ER, Chugh SS, Cornel MC, Gardner K, Ingles J, James CA, Jimmy Juang JM, Kääb S, Kaufman ES, Krahn AD, Lubitz SA, MacLeod H, Morillo CA, Nademanee K, Probst V, Saarel EV, Sacilotto L, Semsarian C, Sheppard MN, Shimizu W, Skinner JR, Tfelt-Hansen J, Wang DW
Heart Rhythm 2021 Jan;18(1):e1-e50. Epub 2020 Oct 19 doi: 10.1016/j.hrthm.2020.10.010. PMID: 33091602Free PMC Article
Steinberg C
Curr Opin Cardiol 2018 Jan;33(1):31-41. doi: 10.1097/HCO.0000000000000465. PMID: 28984650

Recent clinical studies

Etiology

Simpson HD, Schulze-Bonhage A, Cascino GD, Fisher RS, Jobst BC, Sperling MR, Lundstrom BN
Epilepsia 2022 Oct;63(10):2445-2460. Epub 2022 Aug 9 doi: 10.1111/epi.17329. PMID: 35700144Free PMC Article
Shamseldin HE, AlAbdi L, Maddirevula S, Alsaif HS, Alzahrani F, Ewida N, Hashem M, Abdulwahab F, Abuyousef O, Kuwahara H, Gao X; Molecular Autopsy Consortium, Alkuraya FS
Genome Med 2021 Oct 13;13(1):161. doi: 10.1186/s13073-021-00973-0. PMID: 34645488Free PMC Article
Bonardi CM, Heyne HO, Fiannacca M, Fitzgerald MP, Gardella E, Gunning B, Olofsson K, Lesca G, Verbeek N, Stamberger H, Striano P, Zara F, Mancardi MM, Nava C, Syrbe S, Buono S, Baulac S, Coppola A, Weckhuysen S, Schoonjans AS, Ceulemans B, Sarret C, Baumgartner T, Muhle H, Portes VD, Toulouse J, Nougues MC, Rossi M, Demarquay G, Ville D, Hirsch E, Maurey H, Willems M, de Bellescize J, Altuzarra CD, Villeneuve N, Bartolomei F, Picard F, Hornemann F, Koolen DA, Kroes HY, Reale C, Fenger CD, Tan WH, Dibbens L, Bearden DR, Møller RS, Rubboli G
Brain 2021 Dec 31;144(12):3635-3650. doi: 10.1093/brain/awab219. PMID: 34114611
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Wang S, Li L, Tao R, Gao Y
Forensic Sci Int 2017 Jun;275:128-137. Epub 2017 Mar 21 doi: 10.1016/j.forsciint.2017.03.006. PMID: 28363160

Diagnosis

Donnan AM, Schneider AL, Russ-Hall S, Churilov L, Scheffer IE
Neurology 2023 Apr 18;100(16):e1712-e1722. Epub 2023 Feb 7 doi: 10.1212/WNL.0000000000207080. PMID: 36750385Free PMC Article
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Finsterer J, Wahbi K
Acta Cardiol 2016 Aug;71(4):389-94. doi: 10.2143/AC.71.4.3159700. PMID: 27594353
Rabinstein AA
Handb Clin Neurol 2014;119:19-24. doi: 10.1016/B978-0-7020-4086-3.00002-3. PMID: 24365285

Therapy

Simpson HD, Schulze-Bonhage A, Cascino GD, Fisher RS, Jobst BC, Sperling MR, Lundstrom BN
Epilepsia 2022 Oct;63(10):2445-2460. Epub 2022 Aug 9 doi: 10.1111/epi.17329. PMID: 35700144Free PMC Article
Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE Jr, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ; RNS System LTT Study
Neurology 2020 Sep 1;95(9):e1244-e1256. Epub 2020 Jul 20 doi: 10.1212/WNL.0000000000010154. PMID: 32690786Free PMC Article
Asatryan B, Schaller A, Bartholdi D, Medeiros-Domingo A
Ann Noninvasive Electrocardiol 2018 Jul;23(4):e12517. Epub 2017 Nov 30 doi: 10.1111/anec.12517. PMID: 29194874Free PMC Article
Zito JM, Burcu M
J Child Adolesc Psychopharmacol 2017 Aug;27(6):538-545. Epub 2016 Jun 3 doi: 10.1089/cap.2015.0239. PMID: 27258470
Wirrell EC
Can J Neurol Sci 2016 Jun;43 Suppl 3:S13-8. doi: 10.1017/cjn.2016.249. PMID: 27264138

Prognosis

Petek BJ, Churchill TW, Moulson N, Kliethermes SA, Baggish AL, Drezner JA, Patel MR, Ackerman MJ, Kucera KL, Siebert DM, Salerno L, Zigman Suchsland M, Asif IM, Maleszewski JJ, Harmon KG
Circulation 2024 Jan 9;149(2):80-90. Epub 2023 Nov 13 doi: 10.1161/CIRCULATIONAHA.123.065908. PMID: 37955565Free PMC Article
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE Jr, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ; RNS System LTT Study
Neurology 2020 Sep 1;95(9):e1244-e1256. Epub 2020 Jul 20 doi: 10.1212/WNL.0000000000010154. PMID: 32690786Free PMC Article
Devinsky O, Boyce D, Robbins M, Pressler M
Epilepsy Behav 2020 Sep;110:107174. Epub 2020 Jun 9 doi: 10.1016/j.yebeh.2020.107174. PMID: 32531727
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003

Clinical prediction guides

Donnan AM, Schneider AL, Russ-Hall S, Churilov L, Scheffer IE
Neurology 2023 Apr 18;100(16):e1712-e1722. Epub 2023 Feb 7 doi: 10.1212/WNL.0000000000207080. PMID: 36750385Free PMC Article
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Simpson HD, Schulze-Bonhage A, Cascino GD, Fisher RS, Jobst BC, Sperling MR, Lundstrom BN
Epilepsia 2022 Oct;63(10):2445-2460. Epub 2022 Aug 9 doi: 10.1111/epi.17329. PMID: 35700144Free PMC Article
Bonardi CM, Heyne HO, Fiannacca M, Fitzgerald MP, Gardella E, Gunning B, Olofsson K, Lesca G, Verbeek N, Stamberger H, Striano P, Zara F, Mancardi MM, Nava C, Syrbe S, Buono S, Baulac S, Coppola A, Weckhuysen S, Schoonjans AS, Ceulemans B, Sarret C, Baumgartner T, Muhle H, Portes VD, Toulouse J, Nougues MC, Rossi M, Demarquay G, Ville D, Hirsch E, Maurey H, Willems M, de Bellescize J, Altuzarra CD, Villeneuve N, Bartolomei F, Picard F, Hornemann F, Koolen DA, Kroes HY, Reale C, Fenger CD, Tan WH, Dibbens L, Bearden DR, Møller RS, Rubboli G
Brain 2021 Dec 31;144(12):3635-3650. doi: 10.1093/brain/awab219. PMID: 34114611
Tang Y, Stahl-Herz J, Sampson BA
Cardiovasc Pathol 2014 Jan-Feb;23(1):1-4. Epub 2013 Oct 22 doi: 10.1016/j.carpath.2013.09.002. PMID: 24157219

Recent systematic reviews

Gould L, Delavale V, Plovnick C, Wisniewski T, Devinsky O
Epilepsia 2023 Oct;64(10):2539-2549. Epub 2023 Aug 7 doi: 10.1111/epi.17720. PMID: 37466925
Radaelli G, de Souza Santos F, Borelli WV, Pisani L, Nunes ML, Scorza FA, da Costa JC
Epilepsy Behav 2018 Aug;85:32-36. Epub 2018 Jun 13 doi: 10.1016/j.yebeh.2018.05.015. PMID: 29906699
Chan XHS, Win YN, Mawer LJ, Tan JY, Brugada J, White NJ
Lancet Infect Dis 2018 Aug;18(8):913-923. Epub 2018 Jun 18 doi: 10.1016/S1473-3099(18)30297-4. PMID: 29887371Free PMC Article
Ali A, Wu S, Issa NP, Rose S, Towle VL, Warnke P, Tao JX
Epilepsy Behav 2017 Nov;76:1-6. Epub 2017 Sep 13 doi: 10.1016/j.yebeh.2017.08.021. PMID: 28917499
Liebenthal JA, Wu S, Rose S, Ebersole JS, Tao JX
Neurology 2015 Feb 17;84(7):703-9. Epub 2015 Jan 21 doi: 10.1212/WNL.0000000000001260. PMID: 25609764

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