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Essential tremor

MedGen UID:
78725
•Concept ID:
C0270736
•
Disease or Syndrome
Synonyms: Benign essential tremor syndrome; Presenile tremor syndrome
SNOMED CT: Essential tremor (609558009)
 
Related gene: DRD3
 
Monarch Initiative: MONDO:0003233
OMIM® Phenotypic series: PS190300
Orphanet: ORPHA862

Definition

A movement disorder characterized by involuntary and rhythmic shaking of parts of the body, most often the hands or arms, that can be triggered or worsened by physical or environmental stressors. Essential tremor may be progressive and can be inherited in an autosomal dominant manner. [from NCI]

Professional guidelines

PubMed

Diagnosis and Treatment of Essential Tremor.
Wagle Shukla A
Continuum (Minneap Minn) 2022 Oct 1;28(5):1333-1349. doi: 10.1212/CON.0000000000001181. PMID: 36222768
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society.
Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G; Tremor Task Force of the International Parkinson and Movement Disorder Society
Mov Disord 2018 Jan;33(1):75-87. Epub 2017 Nov 30 doi: 10.1002/mds.27121. PMID: 29193359Free PMC Article

Recent clinical studies

Etiology

Essential tremor.
Louis ED
Handb Clin Neurol 2023;196:389-401. doi: 10.1016/B978-0-323-98817-9.00012-0. PMID: 37620080
Essential Tremor - Deep Brain Stimulation vs. Focused Ultrasound.
Ferreira Felloni Borges Y, Cheyuo C, Lozano AM, Fasano A
Expert Rev Neurother 2023 Jul-Dec;23(7):603-619. Epub 2023 Jun 8 doi: 10.1080/14737175.2023.2221789. PMID: 37288812
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
Clinical approach to tremor in children.
Torres-Russotto D
Parkinsonism Relat Disord 2019 Feb;59:111-116. Epub 2019 Mar 23 doi: 10.1016/j.parkreldis.2019.03.015. PMID: 30952437
Essential tremor.
Louis ED
Lancet Neurol 2005 Feb;4(2):100-10. doi: 10.1016/S1474-4422(05)00991-9. PMID: 15664542

Diagnosis

Essential Tremor.
Elias WJ, Shah BB
JAMA 2024 Aug 6;332(5):418-419. doi: 10.1001/jama.2024.7475. PMID: 38976274
Diagnosis and Treatment of Essential Tremor.
Wagle Shukla A
Continuum (Minneap Minn) 2022 Oct 1;28(5):1333-1349. doi: 10.1212/CON.0000000000001181. PMID: 36222768
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Essential Tremor.
Haubenberger D, Hallett M
N Engl J Med 2018 May 10;378(19):1802-1810. doi: 10.1056/NEJMcp1707928. PMID: 29742376
Essential Tremor.
Muth CC
JAMA 2016 Nov 22;316(20):2162. doi: 10.1001/jama.2016.16376. PMID: 27893132

Therapy

Medications used to treat tremors.
Frei K, Truong DD
J Neurol Sci 2022 Apr 15;435:120194. Epub 2022 Feb 19 doi: 10.1016/j.jns.2022.120194. PMID: 35279634
Managing Essential Tremor.
Hopfner F, Deuschl G
Neurotherapeutics 2020 Oct;17(4):1603-1621. doi: 10.1007/s13311-020-00899-2. PMID: 32915385Free PMC Article
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Essential Tremor.
Haubenberger D, Hallett M
N Engl J Med 2018 May 10;378(19):1802-1810. doi: 10.1056/NEJMcp1707928. PMID: 29742376
Essential tremor.
Schwindt G, Rezmovitz J
CMAJ 2017 Nov 6;189(44):E1364. doi: 10.1503/cmaj.170128. PMID: 29109210Free PMC Article

Prognosis

Satisfaction With Telemedicine Consultation as Follow-Up Visit in Patients with Parkinsonism and Essential Tremor in during the Covid-19 Pandemic.
Mayela RV, Yamil M, Amin CA, Yazmín RS, Arturo AC, Daniel MR, Lorena ZV, Karla SB, Manuel DRQ
Neurol India 2022 Sep-Oct;70(5):2003-2008. doi: 10.4103/0028-3886.359193. PMID: 36352601
Technology of deep brain stimulation: current status and future directions.
Krauss JK, Lipsman N, Aziz T, Boutet A, Brown P, Chang JW, Davidson B, Grill WM, Hariz MI, Horn A, Schulder M, Mammis A, Tass PA, Volkmann J, Lozano AM
Nat Rev Neurol 2021 Feb;17(2):75-87. Epub 2020 Nov 26 doi: 10.1038/s41582-020-00426-z. PMID: 33244188Free PMC Article
Essential Tremor with Aspartic Acidemia.
Miura S, Fujioka R, Taniwaki T
Kurume Med J 2017 May 8;63(3.4):81-84. Epub 2017 Mar 15 doi: 10.2739/kurumemedj.MS00015. PMID: 28302933
Essential tremor: not Parkinson's disease.
Johns Hopkins Med Lett Health After 50 2005 Feb;16(12):3, 7. PMID: 15770745
Essential tremor.
Murray TJ
Can Med Assoc J 1981 Jun 15;124(12):1559-65, 1570. PMID: 7018658Free PMC Article

Clinical prediction guides

Subjective and Objective Day-to-Day Performance Measures of People with Essential Tremor.
Roth N, Salih A, Rosenblum S
Sensors (Basel) 2024 Jul 26;24(15) doi: 10.3390/s24154854. PMID: 39123901Free PMC Article
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
Predicting lesion size during focused ultrasound thalamotomy: a review of 63 lesions over 3 clinical trials.
Bond AE, Elias WJ
Neurosurg Focus 2018 Feb;44(2):E5. doi: 10.3171/2017.11.FOCUS17623. PMID: 29385925
Essential Tremor with Aspartic Acidemia.
Miura S, Fujioka R, Taniwaki T
Kurume Med J 2017 May 8;63(3.4):81-84. Epub 2017 Mar 15 doi: 10.2739/kurumemedj.MS00015. PMID: 28302933
Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry.
Louis ED
Lancet Neurol 2010 Jun;9(6):613-22. Epub 2010 May 5 doi: 10.1016/S1474-4422(10)70090-9. PMID: 20451458

Recent systematic reviews

Association between irritable bowel syndrome and Parkinson's disease: A systematic review and meta-analysis.
Lu S, Jiang HY, Shi YD
Acta Neurol Scand 2022 Apr;145(4):442-448. Epub 2021 Dec 15 doi: 10.1111/ane.13570. PMID: 34908158
Sleep disorders in essential tremor: systematic review and meta-analysis.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG
Sleep 2020 Sep 14;43(9) doi: 10.1093/sleep/zsaa039. PMID: 32163585
A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology: Advances in Diagnosis and Treatment.
Krishna V, Sammartino F, Rezai A
JAMA Neurol 2018 Feb 1;75(2):246-254. doi: 10.1001/jamaneurol.2017.3129. PMID: 29228074
Topiramate for essential tremor.
Bruno E, Nicoletti A, Quattrocchi G, Allegra R, Filippini G, Colosimo C, Zappia M
Cochrane Database Syst Rev 2017 Apr 14;4(4):CD009683. doi: 10.1002/14651858.CD009683.pub2. PMID: 28409827Free PMC Article
Essential tremor.
Ferreira JJ, Sampaio C
BMJ Clin Evid 2007 May 1;2007 PMID: 19454072Free PMC Article

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