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Aortic dilatation

MedGen UID:
78118
•Concept ID:
C0265004
•
Finding; Pathologic Function
Synonyms: Aortic dilation; Aortic ectasia
SNOMED CT: Dilatation of aorta (26660001)

Definition

A pathologic widening of the aortic lumen. It is often associated with hypertensive vascular disease and may progress to dissection and rupture. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Update in the management of type B aortic dissection.
Nauta FJ, Trimarchi S, Kamman AV, Moll FL, van Herwaarden JA, Patel HJ, Figueroa CA, Eagle KA, Froehlich JB
Vasc Med 2016 Jun;21(3):251-63. Epub 2016 Apr 11 doi: 10.1177/1358863X16642318. PMID: 27067136
Prospects for the medical management of abdominal aortic aneurysms.
Steinmetz EF, Buckley C, Thompson RW
Vasc Endovascular Surg 2003 May-Jun;37(3):151-63. doi: 10.1177/153857440303700301. PMID: 12799723

Recent clinical studies

Etiology

Expanding the phenotypic spectrum of Chromosome 16p13.11 microduplication: A multicentric analysis of 206 patients.
Hamad A, Sherlaw-Sturrock CA, Glover K, Salmon R, Low K, Nair R, Sansbury FH, Rawlins L, Carmichael J, Horton R, Wedderburn S, Edgerley K, Irving R, Callaghan M, Mercer C, McGowan R, Robert L, Titheradge H, Naik S
Eur J Med Genet 2023 Apr;66(4):104714. Epub 2023 Jan 29 doi: 10.1016/j.ejmg.2023.104714. PMID: 36724812
Abdominal Aortic Aneurysm.
Haque K, Bhargava P
Am Fam Physician 2022 Aug;106(2):165-172. PMID: 35977132
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Aortic surgery in pregnancy.
Lansman SL, Goldberg JB, Kai M, Tang GH, Malekan R, Spielvogel D
J Thorac Cardiovasc Surg 2017 Feb;153(2):S44-S48. Epub 2016 Jun 24 doi: 10.1016/j.jtcvs.2016.06.015. PMID: 27431443
Echocardiographic findings in patients with spontaneous CSF leak.
Pimienta AL, Rimoin DL, Pariani M, Schievink WI, Reinstein E
J Neurol 2014 Oct;261(10):1957-60. Epub 2014 Jul 25 doi: 10.1007/s00415-014-7438-0. PMID: 25059392

Diagnosis

Expanding the phenotypic spectrum of Chromosome 16p13.11 microduplication: A multicentric analysis of 206 patients.
Hamad A, Sherlaw-Sturrock CA, Glover K, Salmon R, Low K, Nair R, Sansbury FH, Rawlins L, Carmichael J, Horton R, Wedderburn S, Edgerley K, Irving R, Callaghan M, Mercer C, McGowan R, Robert L, Titheradge H, Naik S
Eur J Med Genet 2023 Apr;66(4):104714. Epub 2023 Jan 29 doi: 10.1016/j.ejmg.2023.104714. PMID: 36724812
Abdominal Aortic Aneurysm.
Haque K, Bhargava P
Am Fam Physician 2022 Aug;106(2):165-172. PMID: 35977132
Shprintzen-Goldberg syndrome and aortic dilatation: apropos of 2 new cases.
Trujillo-Quintero JP, Gabau Vila E, Larrañaga Moreira JM, Ruiz Nel Lo A, Monserrat L, Barriales-Villa R
Rev Esp Cardiol (Engl Ed) 2021 Jun;74(6):551-553. Epub 2021 Jan 18 doi: 10.1016/j.rec.2020.11.006. PMID: 33478915
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
PET in vasculitis.
Blockmans D
Ann N Y Acad Sci 2011 Jun;1228:64-70. doi: 10.1111/j.1749-6632.2011.06021.x. PMID: 21718324

Therapy

An unusual cause of positional hypoxaemia: platypnoea-orthodeoxia syndrome associated with patent foramen ovale and ascending aortic dilatation.
Han HJ, Lee J, Kim Y
Eur Heart J Cardiovasc Imaging 2024 Jan 29;25(2):e96. doi: 10.1093/ehjci/jead267. PMID: 37852090
Case 16-2021: A 37-Year-Old Woman with Abdominal Pain and Aortic Dilatation.
Dua A, Sutphin PD, Siedner MJ, Moran J
N Engl J Med 2021 May 27;384(21):2054-2063. doi: 10.1056/NEJMcpc2100278. PMID: 34042393
Role of losartan in prevention of aortic dilatation in Marfan syndrome: A systematic review and meta-analysis.
Li L, Yamani N, Al-Naimat S, Khurshid A, Usman MS
Eur J Prev Cardiol 2020 Sep;27(13):1447-1450. Epub 2019 Jul 1 doi: 10.1177/2047487319861231. PMID: 31260329
Post-stenotic aortic dilatation.
Wilton E, Jahangiri M
J Cardiothorac Surg 2006 Mar 3;1:7. doi: 10.1186/1749-8090-1-7. PMID: 16722611Free PMC Article
Prospects for the medical management of abdominal aortic aneurysms.
Steinmetz EF, Buckley C, Thompson RW
Vasc Endovascular Surg 2003 May-Jun;37(3):151-63. doi: 10.1177/153857440303700301. PMID: 12799723

Prognosis

Proximal aorta dilatation in hypertension.
Zuo X, Liu L, Liu K, Zhang X, Ye R, Yang C, Ma J, Jia S, Yang X, Liu X, Sun L, Huo X, Chen X
J Hypertens 2023 Oct 1;41(10):1511-1520. Epub 2023 Aug 2 doi: 10.1097/HJH.0000000000003518. PMID: 37642588
Sex, gender, and subclinical hypertensiveorgan damage-heart.
Cuspidi C, Gherbesi E, Sala C, Tadic M
J Hum Hypertens 2023 Aug;37(8):626-633. Epub 2022 Aug 27 doi: 10.1038/s41371-022-00750-5. PMID: 36030347
PET in vasculitis.
Blockmans D
Ann N Y Acad Sci 2011 Jun;1228:64-70. doi: 10.1111/j.1749-6632.2011.06021.x. PMID: 21718324
Identification of the minimal combination of clinical features in probands for efficient mutation detection in the FBN1 gene.
Stheneur C, Collod-Béroud G, Faivre L, Buyck JF, Gouya L, Le Parc JM, Moura B, Muti C, Grandchamp B, Sultan G, Claustres M, Aegerter P, Chevallier B, Jondeau G, Boileau C
Eur J Hum Genet 2009 Sep;17(9):1121-8. Epub 2009 Mar 18 doi: 10.1038/ejhg.2009.36. PMID: 19293843Free PMC Article
Effect of mutation type and location on clinical outcome in 1,013 probands with Marfan syndrome or related phenotypes and FBN1 mutations: an international study.
Faivre L, Collod-Beroud G, Loeys BL, Child A, Binquet C, Gautier E, Callewaert B, Arbustini E, Mayer K, Arslan-Kirchner M, Kiotsekoglou A, Comeglio P, Marziliano N, Dietz HC, Halliday D, Beroud C, Bonithon-Kopp C, Claustres M, Muti C, Plauchu H, Robinson PN, Adès LC, Biggin A, Benetts B, Brett M, Holman KJ, De Backer J, Coucke P, Francke U, De Paepe A, Jondeau G, Boileau C
Am J Hum Genet 2007 Sep;81(3):454-66. Epub 2007 Jul 25 doi: 10.1086/520125. PMID: 17701892Free PMC Article

Clinical prediction guides

Proximal aorta dilatation in hypertension.
Zuo X, Liu L, Liu K, Zhang X, Ye R, Yang C, Ma J, Jia S, Yang X, Liu X, Sun L, Huo X, Chen X
J Hypertens 2023 Oct 1;41(10):1511-1520. Epub 2023 Aug 2 doi: 10.1097/HJH.0000000000003518. PMID: 37642588
Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis.
Bray JJH, Freer R, Pitcher A, Kharbanda R
Eur Heart J 2023 Sep 1;44(33):3152-3164. doi: 10.1093/eurheartj/ehad320. PMID: 37288540Free PMC Article
PET in vasculitis.
Blockmans D
Ann N Y Acad Sci 2011 Jun;1228:64-70. doi: 10.1111/j.1749-6632.2011.06021.x. PMID: 21718324
Identification of the minimal combination of clinical features in probands for efficient mutation detection in the FBN1 gene.
Stheneur C, Collod-Béroud G, Faivre L, Buyck JF, Gouya L, Le Parc JM, Moura B, Muti C, Grandchamp B, Sultan G, Claustres M, Aegerter P, Chevallier B, Jondeau G, Boileau C
Eur J Hum Genet 2009 Sep;17(9):1121-8. Epub 2009 Mar 18 doi: 10.1038/ejhg.2009.36. PMID: 19293843Free PMC Article
Prospects for the medical management of abdominal aortic aneurysms.
Steinmetz EF, Buckley C, Thompson RW
Vasc Endovascular Surg 2003 May-Jun;37(3):151-63. doi: 10.1177/153857440303700301. PMID: 12799723

Recent systematic reviews

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis.
Bray JJH, Freer R, Pitcher A, Kharbanda R
Eur Heart J 2023 Sep 1;44(33):3152-3164. doi: 10.1093/eurheartj/ehad320. PMID: 37288540Free PMC Article
Cardiac and Aortic Modifications After Endovascular Repair for Blunt Thoracic Aortic Injury: A Systematic Review.
Mandigers TJ, Bissacco D, Domanin M, D'Alessio I, Tolva VS, Piffaretti G, van Herwaarden JA, Trimarchi S
Eur J Vasc Endovasc Surg 2022 Aug-Sep;64(2-3):176-187. Epub 2022 May 7 doi: 10.1016/j.ejvs.2022.05.004. PMID: 35537638
Role of losartan in prevention of aortic dilatation in Marfan syndrome: A systematic review and meta-analysis.
Li L, Yamani N, Al-Naimat S, Khurshid A, Usman MS
Eur J Prev Cardiol 2020 Sep;27(13):1447-1450. Epub 2019 Jul 1 doi: 10.1177/2047487319861231. PMID: 31260329
Management and Outcomes of Aortic Dissection in Pregnancy with Marfan Syndrome: A Systematic Review.
Al-Thani H, Mekkodathil A, El-Menyar A
Curr Vasc Pharmacol 2020;18(3):282-293. doi: 10.2174/1570161117666190408164612. PMID: 30963974
Exercise and sports participation in patients with thoracic aortic disease: a review.
Thijssen CGE, Bons LR, Gökalp AL, Van Kimmenade RRJ, Mokhles MM, Pelliccia A, Takkenberg JJM, Roos-Hesselink JW
Expert Rev Cardiovasc Ther 2019 Apr;17(4):251-266. Epub 2019 Mar 21 doi: 10.1080/14779072.2019.1585807. PMID: 30887852

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