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Carcinoma of pancreas

MedGen UID:
65917
•Concept ID:
C0235974
•
Neoplastic Process
Synonyms: Exocrine pancreatic carcinoma; PANCREATIC ACINAR CARCINOMA; Pancreatic cancer, somatic; PANCREATIC CARCINOMA; Pancreatic carcinoma, somatic
SNOMED CT: Carcinoma of pancreas (372142002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Related genes: TP53, STK11, SMAD4, KRAS, ACVR1B
 
Monarch Initiative: MONDO:0005192
OMIM®: 260350
Orphanet: ORPHA217074

Definition

A carcinoma arising from the exocrine pancreas. The overwhelming majority of pancreatic carcinomas are adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Carcinoma of pancreas in Orphanet.

Professional guidelines

PubMed

Influence of multimodality therapy on the management of pancreas carcinoma.
Jessup JM, Posner M, Huberman M
Semin Surg Oncol 1993 Jan-Feb;9(1):27-32. doi: 10.1002/ssu.2980090106. PMID: 8356381
A comparison of ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the differential diagnosis of benign and malignant jaundice and cholestasis.
Pasanen PA, Partanen KP, Pikkarainen PH, Alhava EM, Janatuinen EK, Pirinen AE
Eur J Surg 1993 Jan;159(1):23-9. PMID: 8095802
Carcinoembryonic antigen in differential diagnosis of carcinoma of pancreas from chronic pancreatitis.
Dilawari JB, Philippakos D, Blendis LM, Waller SL
Br Med J 1975 Jun 21;2(5972):668. doi: 10.1136/bmj.2.5972.668. PMID: 1139173Free PMC Article

Curated

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

Gut microbiota and pancreatic cancer risk, and the mediating role of immune cells and inflammatory cytokines: a Mendelian randomization study.
Chen Z, Wang Z, Bao H, Ma S
Front Immunol 2024;15:1408770. Epub 2024 Jul 25 doi: 10.3389/fimmu.2024.1408770. PMID: 39119339Free PMC Article
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
In situ carcinoma of pancreas diagnosed by EUS-FNA.
Sakamoto H, Kitano M, Dote K, Tchikugo T, Takeyama Y, Kudo M
Endoscopy 2008 Sep;40 Suppl 2:E15-6. Epub 2008 Feb 18 doi: 10.1055/s-2007-966708. PMID: 18278717
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM
Oncogene 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785
ABO blood groups and carcinoma of pancreas.
Macafee AL
Ulster Med J 1964 Dec;33(2):129-31. PMID: 5881423Free PMC Article

Diagnosis

Acinar Cell Carcinoma of Pancreas: a Case Report and Review of Literature.
Makineni H, Seshadri RA, Sundersingh S
J Gastrointest Cancer 2019 Mar;50(1):134-136. doi: 10.1007/s12029-017-9987-9. PMID: 28660524
Unusual Case of Squamous Cell Carcinoma of Pancreas with Review of Literature.
Mehta M, Sinha J, Ogawa M, Ganguly A, Xiang D, Poddar N
J Gastrointest Cancer 2015 Dec;46(4):426-9. doi: 10.1007/s12029-015-9712-5. PMID: 25894633
Mixed ductal-endocrine carcinoma of pancreas.
Ahmad Z, Mumtaz S, Fatima S, Qureshi A
BMJ Case Rep 2011 Apr 19;2011 doi: 10.1136/bcr.02.2011.3861. PMID: 22696627Free PMC Article
Image of the month. Solid pseudopapillary carcinoma of pancreas with liver metastasis.
Chong CN, Lee KF, Wong J, Lai PB
Arch Surg 2006 Aug;141(8):831. doi: 10.1001/archsurg.141.8.831. PMID: 16924091
Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin.
Rosai J
Cancer 1968 Aug;22(2):333-44. doi: 10.1002/1097-0142(196808)22:2<333::aid-cncr2820220210>3.0.co;2-a. PMID: 5660199

Therapy

Gut microbiota and pancreatic cancer risk, and the mediating role of immune cells and inflammatory cytokines: a Mendelian randomization study.
Chen Z, Wang Z, Bao H, Ma S
Front Immunol 2024;15:1408770. Epub 2024 Jul 25 doi: 10.3389/fimmu.2024.1408770. PMID: 39119339Free PMC Article
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Establishment and characterization of a pancreatic carcinoma cell line derived from malignant pleural effusion.
Starr AN, Vexler A, Marmor S, Konik D, Ashkenasi-Voghera M, Lev-Ari S, Greif Y, Ben-Yosef R
Oncology 2005;69(3):239-45. Epub 2005 Sep 2 doi: 10.1159/000088071. PMID: 16141719
Carcinoma of pancreas--palliative radiotherapy.
Green N, Beron E, Melbye RW, George FW 3rd
Am J Roentgenol Radium Ther Nucl Med 1973 Mar;117(3):620-2. doi: 10.2214/ajr.117.3.620. PMID: 4120876

Prognosis

Colloid Carcinoma of Pancreas in the Setting of Intraductal Papillary Mucinous Neoplasm (IPMN).
Jayakrishnan T, Pandya D, Monga D
J Gastrointest Cancer 2020 Jun;51(2):658-662. doi: 10.1007/s12029-019-00322-w. PMID: 31811471
Unusual Case of Squamous Cell Carcinoma of Pancreas with Review of Literature.
Mehta M, Sinha J, Ogawa M, Ganguly A, Xiang D, Poddar N
J Gastrointest Cancer 2015 Dec;46(4):426-9. doi: 10.1007/s12029-015-9712-5. PMID: 25894633
Mixed ductal-endocrine carcinoma of pancreas.
Ahmad Z, Mumtaz S, Fatima S, Qureshi A
BMJ Case Rep 2011 Apr 19;2011 doi: 10.1136/bcr.02.2011.3861. PMID: 22696627Free PMC Article
In situ carcinoma of pancreas diagnosed by EUS-FNA.
Sakamoto H, Kitano M, Dote K, Tchikugo T, Takeyama Y, Kudo M
Endoscopy 2008 Sep;40 Suppl 2:E15-6. Epub 2008 Feb 18 doi: 10.1055/s-2007-966708. PMID: 18278717
Pancreatic carcinoma.
Ajao OG, Abioye AA
J Natl Med Assoc 1980 Jun;72(6):589-90. PMID: 7392077Free PMC Article

Clinical prediction guides

Celiac Plexus Denudation in Triangle Dissection in Pancreatico Duodenectomy: Perioperative Anesthetic Implications.
Shrestha BR , Sharma M , Barahi Shrestha S , Thapa PB , Maharjan DK
Kathmandu Univ Med J (KUMJ) 2022 Jan-Mar;20(77):119-121. PMID: 36273306
Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs.
Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS
Clin Exp Rheumatol 2022 May;40(5):913-920. Epub 2021 Jul 24 doi: 10.55563/clinexprheumatol/o3rgv1. PMID: 34369368
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM
Oncogene 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785
Laparoscopic cholecystjejunostomy as palliation for obstructive jaundice in inoperable carcinoma of pancreas.
Fletcher DR, Jones RM
Surg Endosc 1992 May-Jun;6(3):147-9. doi: 10.1007/BF02309090. PMID: 1380188

Supplemental Content

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    Curated

    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
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