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Pyogenic granuloma

MedGen UID:
39085
•Concept ID:
C0085653
•
Neoplastic Process
Synonyms: Lobular capillary hemangioma; PG
SNOMED CT: PG - Pyogenic granuloma (39629007); Capillary hemangioma of granulation tissue type (17372009); Lobular capillary hemangioma (17372009); Granuloma pyogenicum (17372009); Pyogenic granuloma (17372009); Granuloma telangiectaticum (17372009); Pyogenic granuloma (200722003)
 
Monarch Initiative: MONDO:0022096

Definition

A friable, benign vascular neoplasm with lobular capillary architecture that presents as a raised red skin growth. [from NCI]

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Successful treatment of eruptive pyogenic granuloma with propranolol.
Fattore D, Di Guida A, Detoraki A, De Fata Salvatores G, Gallo L, Fabbrocini G
Dermatol Ther 2021 Jul;34(4):e14998. Epub 2021 Jun 18 doi: 10.1111/dth.14998. PMID: 34028922Free PMC Article
Clinical inquiries. What's the best treatment for pyogenic granuloma?
Gilmore A, Kelsberg G, Safranek S
J Fam Pract 2010 Jan;59(1):40-2. PMID: 20074501

Recent clinical studies

Etiology

Physiology of pregnancy and oral local anesthesia considerations.
Zhou X, Zhong Y, Pan Z, Zhang J, Pan J
PeerJ 2023;11:e15585. Epub 2023 Jun 29 doi: 10.7717/peerj.15585. PMID: 37404472Free PMC Article
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Oral health during pregnancy.
Silk H, Douglass AB, Douglass JM, Silk L
Am Fam Physician 2008 Apr 15;77(8):1139-44. PMID: 18481562

Diagnosis

Oral Pyogenic Granuloma: A Narrative Review.
Lomeli Martinez SM, Carrillo Contreras NG, Gómez Sandoval JR, Zepeda Nuño JS, Gomez Mireles JC, Varela Hernández JJ, Mercado-González AE, Bayardo González RA, Gutiérrez-Maldonado AF
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316885. PMID: 38069207Free PMC Article
Pyogenic Granuloma.
Komakech D, Ssenkumba B
N Engl J Med 2022 Nov 24;387(21):1979. doi: 10.1056/NEJMicm2204602. PMID: 36416770
Duodenal Pyogenic Granuloma.
Paleti S, Fischer EG, Rustagi T
Clin Gastroenterol Hepatol 2021 Jul;19(7):e73. Epub 2020 Apr 30 doi: 10.1016/j.cgh.2020.04.064. PMID: 32360803
Congenital Vascular Tumors.
Goss JA, Greene AK
Otolaryngol Clin North Am 2018 Feb;51(1):89-97. doi: 10.1016/j.otc.2017.09.008. PMID: 29217070
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715

Therapy

Physiology of pregnancy and oral local anesthesia considerations.
Zhou X, Zhong Y, Pan Z, Zhang J, Pan J
PeerJ 2023;11:e15585. Epub 2023 Jun 29 doi: 10.7717/peerj.15585. PMID: 37404472Free PMC Article
RF - FTopical Timolol in Dermatology.
Lopez-Bernal T, Aranegui B
Actas Dermosifiliogr 2023 Apr;114(4):334-335. Epub 2022 Sep 17 doi: 10.1016/j.ad.2021.09.014. PMID: 36126701
Chemotherapy-induced periungual pyogenic granuloma: epidemiology and recurrence rates in our experience.
Annunziata MC, Vastarella M, Marasca C, Panariello L, Donnarumma M, Fabbrocini G
Ital J Dermatol Venerol 2022 Apr;157(2):198-199. Epub 2018 Oct 11 doi: 10.23736/S2784-8671.18.06128-X. PMID: 30318883
Topical beta-blockers in dermatologic therapy.
Filoni A, Ambrogio F, De Marco A, Pacifico A, Bonamonte D
Dermatol Ther 2021 Jul;34(4):e15016. Epub 2021 Jun 21 doi: 10.1111/dth.15016. PMID: 34075667Free PMC Article
Oral pyogenic granuloma: a review.
Jafarzadeh H, Sanatkhani M, Mohtasham N
J Oral Sci 2006 Dec;48(4):167-75. doi: 10.2334/josnusd.48.167. PMID: 17220613

Prognosis

Pediatric melanoma update.
Mccormack L, Hawryluk EB
G Ital Dermatol Venereol 2018 Oct;153(5):707-715. Epub 2018 Feb 26 doi: 10.23736/S0392-0488.18.05924-2. PMID: 29485257
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Kaposi sarcoma.
Radu O, Pantanowitz L
Arch Pathol Lab Med 2013 Feb;137(2):289-94. doi: 10.5858/arpa.2012-0101-RS. PMID: 23368874
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715
Disseminated lobular capillary haemangioma.
Behne K, Robertson I, Weedon D
Australas J Dermatol 2002 Nov;43(4):297-300. doi: 10.1046/j.1440-0960.2002.00617.x. PMID: 12423439

Clinical prediction guides

Pyogenic granuloma of the colon observed by magnifying endoscopy and treated by endoscopic submucosal dissection.
Kawasaki K, Kawatoko S, Iwatake S, Kohashi K, Torisu T
Gastrointest Endosc 2023 Jun;97(6):1164-1165. Epub 2023 Jan 21 doi: 10.1016/j.gie.2023.01.032. PMID: 36693500
World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.
Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, Gonçalves S, Lodi G, Hodgson TA
Oral Dis 2019 Jun;25 Suppl 1:193-203. doi: 10.1111/odi.13112. PMID: 31034120
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Congenital and disseminated pyogenic granuloma-like vascular lesions.
Mallet S, Rebelle C, Ligi I, Scavarda D, Bouvier C, Petit P, Fraitag S, Wassef M, Gaudy-Marqueste C, Hesse S, Richard MA, Grob JJ, André N
Acta Derm Venereol 2015 Sep;95(7):860-1. doi: 10.2340/00015555-2078. PMID: 25720992
Treatment options for cutaneous pyogenic granulomas: a review.
Lee J, Sinno H, Tahiri Y, Gilardino MS
J Plast Reconstr Aesthet Surg 2011 Sep;64(9):1216-20. Epub 2011 Feb 11 doi: 10.1016/j.bjps.2010.12.021. PMID: 21316320

Recent systematic reviews

Acitretin-induced periungual pyogenic granulomas and review.
Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333
Beta-Blockers for Pyogenic Granuloma: A Systematic Review of Case Reports, Case Series, and Clinical Trials.
Dany M
J Drugs Dermatol 2019 Oct 1;18(10):1006-1010. PMID: 31584779
Cutaneous presentations of omphalomesenteric duct remnant: A systematic review of the literature.
Solomon-Cohen E, Lapidoth M, Snast I, Ben-Amitai D, Zidan O, Friedland R, Moshe M, Mimouni D, Leshem YA, Hodak E, Levi A
J Am Acad Dermatol 2019 Nov;81(5):1120-1126. Epub 2019 Feb 21 doi: 10.1016/j.jaad.2019.02.033. PMID: 30797849
Therapeutic approaches to pyogenic granuloma: an updated review.
Plachouri KM, Georgiou S
Int J Dermatol 2019 Jun;58(6):642-648. Epub 2018 Oct 21 doi: 10.1111/ijd.14268. PMID: 30345507
Reactive oral lesions associated with dental implants. A systematic review.
Atarbashi-Moghadam F, Atarbashi-Moghadam S, Namdari M, Shahrabi-Farahani S
J Investig Clin Dent 2018 Nov;9(4):e12342. Epub 2018 May 11 doi: 10.1111/jicd.12342. PMID: 29752778

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