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Dissecting aortic dilatation

MedGen UID:
8439
•Concept ID:
C0012736
•
Disease or Syndrome
Synonym: Aortic aneurysm/dissection

Definition

A dissecting aneurysm formed between the intimal and medial layers of the aortic wall due to a tear in the tunica intima. [from NCI]

Professional guidelines

PubMed

Cardiovascular Management of Aortopathy in Children: A Scientific Statement From the American Heart Association.
Morris SA, Flyer JN, Yetman AT, Quezada E, Cappella ES, Dietz HC, Milewicz DM, Ouzounian M, Rigelsky CM, Tierney S, Lacro RV; American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young (Young Hearts); Council on Cardiovascular and Stroke Nursing; Council on Peripheral Vascular Disease; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; and Council on Cardiovascular Surgery and Anesthesia
Circulation 2024 Sep 10;150(11):e228-e254. Epub 2024 Aug 12 doi: 10.1161/CIR.0000000000001265. PMID: 39129620
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142

Recent clinical studies

Etiology

Mechanisms of Aortic Dilation in Patients With Bicuspid Aortic Valve: JACC State-of-the-Art Review.
Rodríguez-Palomares JF, Dux-Santoy L, Guala A, Galian-Gay L, Evangelista A
J Am Coll Cardiol 2023 Aug 1;82(5):448-464. doi: 10.1016/j.jacc.2022.10.042. PMID: 37495282
Bicuspid aortic valve associated aortopathy: 2022 guideline update.
Verma R, Cohen G, Colbert J, Fedak PWM
Curr Opin Cardiol 2023 Mar 1;38(2):61-67. Epub 2022 Dec 29 doi: 10.1097/HCO.0000000000001020. PMID: 36718616
Clinical Features and Outcomes of Pregnancy-Related Acute Aortic Dissection.
Braverman AC, Mittauer E, Harris KM, Evangelista A, Pyeritz RE, Brinster D, Conklin L, Suzuki T, Fanola C, Ouzounian M, Chen E, Myrmel T, Bekeredjian R, Hutchison S, Coselli J, Gilon D, O'Gara P, Davis M, Isselbacher E, Eagle K
JAMA Cardiol 2021 Jan 1;6(1):58-66. doi: 10.1001/jamacardio.2020.4876. PMID: 33052376Free PMC Article
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Sudden death due to aortic pathology.
Papagiannis J
Cardiol Young 2017 Jan;27(S1):S36-S42. doi: 10.1017/S1047951116002213. PMID: 28084959

Diagnosis

Bicuspid aortic valve associated aortopathy: 2022 guideline update.
Verma R, Cohen G, Colbert J, Fedak PWM
Curr Opin Cardiol 2023 Mar 1;38(2):61-67. Epub 2022 Dec 29 doi: 10.1097/HCO.0000000000001020. PMID: 36718616
Pathophysiology and Pathogenesis of Marfan Syndrome.
Zeigler SM, Sloan B, Jones JA
Adv Exp Med Biol 2021;1348:185-206. doi: 10.1007/978-3-030-80614-9_8. PMID: 34807420Free PMC Article
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Segmental arterial mediolysis.
Jurado Basildo C, Santos Armentia E, Silva Priege N, Villanueva Campos AM
Radiologia (Engl Ed) 2019 Sep-Oct;61(5):430-434. Epub 2019 May 30 doi: 10.1016/j.rx.2019.04.002. PMID: 31155224
Sudden death due to aortic pathology.
Papagiannis J
Cardiol Young 2017 Jan;27(S1):S36-S42. doi: 10.1017/S1047951116002213. PMID: 28084959

Therapy

Late complications of the Djumbodis system in patients with type A acute aortic dissection.
Vendramin I, Piani D, Lechiancole A, Sponga S, Sponza M, Puppato M, Bortolotti U, Livi U
Interact Cardiovasc Thorac Surg 2020 Nov 1;31(5):704-707. doi: 10.1093/icvts/ivaa178. PMID: 33007070
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160
Surgery for congenital diseases of the aorta.
Cameron D
J Thorac Cardiovasc Surg 2015 Feb;149(2 Suppl):S14-7. Epub 2014 Oct 23 doi: 10.1016/j.jtcvs.2014.10.084. PMID: 25726075
Turner syndrome: diagnosis and management.
Morgan T
Am Fam Physician 2007 Aug 1;76(3):405-10. PMID: 17708142
Nitroprusside.
Cohn JN, Burke LP
Ann Intern Med 1979 Nov;91(5):752-7. doi: 10.7326/0003-4819-91-5-752. PMID: 496116

Prognosis

Proximal aorta dilatation in hypertension.
Zuo X, Liu L, Liu K, Zhang X, Ye R, Yang C, Ma J, Jia S, Yang X, Liu X, Sun L, Huo X, Chen X
J Hypertens 2023 Oct 1;41(10):1511-1520. Epub 2023 Aug 2 doi: 10.1097/HJH.0000000000003518. PMID: 37642588
Clinical Features and Outcomes of Pregnancy-Related Acute Aortic Dissection.
Braverman AC, Mittauer E, Harris KM, Evangelista A, Pyeritz RE, Brinster D, Conklin L, Suzuki T, Fanola C, Ouzounian M, Chen E, Myrmel T, Bekeredjian R, Hutchison S, Coselli J, Gilon D, O'Gara P, Davis M, Isselbacher E, Eagle K
JAMA Cardiol 2021 Jan 1;6(1):58-66. doi: 10.1001/jamacardio.2020.4876. PMID: 33052376Free PMC Article
Late complications of the Djumbodis system in patients with type A acute aortic dissection.
Vendramin I, Piani D, Lechiancole A, Sponga S, Sponza M, Puppato M, Bortolotti U, Livi U
Interact Cardiovasc Thorac Surg 2020 Nov 1;31(5):704-707. doi: 10.1093/icvts/ivaa178. PMID: 33007070
Aortic dissections following heart transplantations.
Skalsky I, Urban M, Malouskova J, Szarszoi O, Pirk J, Netuka I
J Card Surg 2012 Jan;27(1):125-7. doi: 10.1111/j.1540-8191.2011.01390.x. PMID: 22321119
Bicuspid aortic valve disease.
Siu SC, Silversides CK
J Am Coll Cardiol 2010 Jun 22;55(25):2789-800. doi: 10.1016/j.jacc.2009.12.068. PMID: 20579534

Clinical prediction guides

Bicuspid aortic valve: The most frequent and not so benign congenital heart disease.
Thiene G, Rizzo S, Basso C
Cardiovasc Pathol 2024 May-Jun;70:107604. Epub 2024 Jan 20 doi: 10.1016/j.carpath.2024.107604. PMID: 38253300
Aortic dissection during endurance cycling.
Murphy M
BMJ Case Rep 2023 Nov 17;16(11) doi: 10.1136/bcr-2023-257207. PMID: 37977829Free PMC Article
Bicuspid aortic valve associated aortopathy: 2022 guideline update.
Verma R, Cohen G, Colbert J, Fedak PWM
Curr Opin Cardiol 2023 Mar 1;38(2):61-67. Epub 2022 Dec 29 doi: 10.1097/HCO.0000000000001020. PMID: 36718616
Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue.
Li Y, Ren P, Dawson A, Vasquez HG, Ageedi W, Zhang C, Luo W, Chen R, Li Y, Kim S, Lu HS, Cassis LA, Coselli JS, Daugherty A, Shen YH, LeMaire SA
Circulation 2020 Oct 6;142(14):1374-1388. Epub 2020 Oct 5 doi: 10.1161/CIRCULATIONAHA.120.046528. PMID: 33017217Free PMC Article
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160

Recent systematic reviews

Causes of sudden cardiac death in young athletes and non-athletes: systematic review and meta-analysis: Sudden cardiac death in the young.
D'Ascenzi F, Valentini F, Pistoresi S, Frascaro F, Piu P, Cavigli L, Valente S, Focardi M, Cameli M, Bonifazi M, Metra M, Mondillo S
Trends Cardiovasc Med 2022 Jul;32(5):299-308. Epub 2021 Jun 22 doi: 10.1016/j.tcm.2021.06.001. PMID: 34166791
Management and Outcomes of Aortic Dissection in Pregnancy with Marfan Syndrome: A Systematic Review.
Al-Thani H, Mekkodathil A, El-Menyar A
Curr Vasc Pharmacol 2020;18(3):282-293. doi: 10.2174/1570161117666190408164612. PMID: 30963974
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160
Reintervention after endovascular repair for aortic dissection: A systematic review and meta-analysis.
Zhang L, Zhao Z, Chen Y, Sun Y, Bao J, Jing Z, Zhou J
J Thorac Cardiovasc Surg 2016 Nov;152(5):1279-1288.e3. Epub 2016 Jun 29 doi: 10.1016/j.jtcvs.2016.06.027. PMID: 27453556
Echocardiographic aortic root dilatation in hypertensive patients: a systematic review and meta-analysis.
Covella M, Milan A, Totaro S, Cuspidi C, Re A, Rabbia F, Veglio F
J Hypertens 2014 Oct;32(10):1928-35; discussion 1935. doi: 10.1097/HJH.0000000000000286. PMID: 24979304

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