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Dyssynergia

MedGen UID:
13945
•Concept ID:
C0004134
•
Sign or Symptom
Synonym: Ataxia
SNOMED CT: Ataxia (loss of muscle coordination) (20262006); Ataxia (20262006); Dyssynergia (39384006)
 
HPO: HP:0010867

Definition

A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDyssynergia

Professional guidelines

PubMed

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Pathophysiological basis, clinical assessment, investigation and management of patients with obstruction defecation syndrome.
Bunni J, Laugharne MJ
Langenbecks Arch Surg 2023 Feb 2;408(1):75. doi: 10.1007/s00423-023-02755-1. PMID: 36729157
The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function.
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group
Neurogastroenterol Motil 2020 Jan;32(1):e13679. Epub 2019 Aug 12 doi: 10.1111/nmo.13679. PMID: 31407463Free PMC Article

Recent clinical studies

Etiology

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury.
Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G
World J Urol 2018 Oct;36(10):1517-1527. Epub 2018 May 11 doi: 10.1007/s00345-018-2301-z. PMID: 29752515
Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Detrusor-External Sphincter Dyssynergia: Review of Minimally Invasive and Endoscopic Management.
Barbalat Y, Rutman M
Urology 2016 Apr;90:3-7. Epub 2016 Jan 27 doi: 10.1016/j.urology.2015.11.049. PMID: 26826587
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859

Diagnosis

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Solitary rectal ulcer syndrome.
Felt-Bersma RJF
Curr Opin Gastroenterol 2021 Jan;37(1):59-65. doi: 10.1097/MOG.0000000000000689. PMID: 33060396
Refractory Constipation: How to Evaluate and Treat.
Camilleri M, Brandler J
Gastroenterol Clin North Am 2020 Sep;49(3):623-642. Epub 2020 Jun 14 doi: 10.1016/j.gtc.2020.05.002. PMID: 32718574
Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Spinocerebellar Ataxia.
Wentz S, Jusufbegovic D
Ophthalmology 2017 Jul;124(7):1071. doi: 10.1016/j.ophtha.2017.01.019. PMID: 28645341

Therapy

Non-pharmacologic approach to pediatric constipation.
Santucci NR, Chogle A, Leiby A, Mascarenhas M, Borlack RE, Lee A, Perez M, Russell A, Yeh AM
Complement Ther Med 2021 Jun;59:102711. Epub 2021 Mar 15 doi: 10.1016/j.ctim.2021.102711. PMID: 33737146
Botulinum toxin in multiple sclerosis.
Jost WH
J Neurol 2006 Feb;253 Suppl 1:I16-20. doi: 10.1007/s00415-006-1104-0. PMID: 16477480
Urethral stents for detrusor sphincter dyssynergia.
Nambirajan T, Woolsey S, Mahendra V, Stone AR, Walsh IK
BJU Int 2005 Feb;95(3):350-3. doi: 10.1111/j.1464-410X.2005.05298.x. PMID: 15679792
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859
Detrusor-sphincter dyssynergia.
McGuire EJ, Brady S
J Urol 1979 Jun;121(6):774-7. doi: 10.1016/s0022-5347(17)56987-6. PMID: 458950

Prognosis

Constipation in Parkinson's Disease.
Quigley EMM
Semin Neurol 2023 Aug;43(4):562-571. Epub 2023 Aug 14 doi: 10.1055/s-0043-1771457. PMID: 37579786
Video-Based Deep Learning to Detect Dyssynergic Defecation with 3D High-Definition Anorectal Manometry.
Levy JJ, Navas CM, Chandra JA, Christensen BC, Vaickus LJ, Curley M, Chey WD, Baker JR, Shah ED
Dig Dis Sci 2023 May;68(5):2015-2022. Epub 2022 Nov 19 doi: 10.1007/s10620-022-07759-3. PMID: 36401758
Lower urinary tract dysfunction in patients with multiple sclerosis.
Panicker JN, Fowler CJ
Handb Clin Neurol 2015;130:371-81. doi: 10.1016/B978-0-444-63247-0.00021-3. PMID: 26003255
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859
Female urinary retention.
Wheeler JS Jr, Culkin DJ, Walter JS, Flanigan RC
Urology 1990 May;35(5):428-32. doi: 10.1016/0090-4295(90)80086-3. PMID: 1970915

Clinical prediction guides

Thoracoabdominal Wall Motion-Guided Biofeedback Treatment of Abdominal Distention: A Randomized Placebo-Controlled Trial.
Barba E, Livovsky DM, Accarino A, Azpiroz F
Gastroenterology 2024 Aug;167(3):538-546.e1. Epub 2024 Mar 11 doi: 10.1053/j.gastro.2024.03.005. PMID: 38467383
AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Lower Urinary Tract Function in Familial Spastic Paraplegia.
Sakakibara R, Shimizu A, Takahashi O, Tateno F, Kishi M, Aiba Y, Suzuki H, Yamamoto T, Shibata C, Yamanishi T
Eur Neurol 2018;80(3-4):121-125. Epub 2018 Nov 2 doi: 10.1159/000494030. PMID: 30391939
Symptomatic myoclonus.
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775
Female urinary retention.
Wheeler JS Jr, Culkin DJ, Walter JS, Flanigan RC
Urology 1990 May;35(5):428-32. doi: 10.1016/0090-4295(90)80086-3. PMID: 1970915

Recent systematic reviews

Use of Botulinum Toxin A (BoNT-A) in Detrusor External Sphincter Dyssynergia (DESD): A Systematic Review and Meta-analysis.
Goel S, Pierce H, Pain K, Christos P, Dmochowski R, Chughtai B
Urology 2020 Jun;140:7-13. Epub 2020 Mar 19 doi: 10.1016/j.urology.2020.03.007. PMID: 32197987
Chronic Urinary Retention in Multiple Sclerosis Patients: Physiology, Systematic Review of Urodynamic Data, and Recommendations for Care.
Stoffel JT
Urol Clin North Am 2017 Aug;44(3):429-439. doi: 10.1016/j.ucl.2017.04.009. PMID: 28716323
Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation.
Whitehead WE, Palsson OS, Simrén M
Neurogastroenterol Motil 2016 Jun;28(6):783-92. doi: 10.1111/nmo.12852. PMID: 27214096
Iatrogenic urological triggers of autonomic dysreflexia: a systematic review.
Liu N, Zhou M, Biering-Sørensen F, Krassioukov AV
Spinal Cord 2015 Jul;53(7):500-9. Epub 2015 Mar 24 doi: 10.1038/sc.2015.39. PMID: 25800696
Sphincterotomy for biliary sphincter of Oddi dysfunction.
Craig AG, Toouli J
Cochrane Database Syst Rev 2001;(3):CD001509. doi: 10.1002/14651858.CD001509. PMID: 11686993

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    Related information

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